We used a combined experimental and numerical parameter peeling procedure was implemented to optimize a detailed ionic mechanism for the generation and propagation of dendritic spikes in neocortical L5 pyramidal neurons. Run the cc_run.hoc to get a demo for dendritic calcium spike generated by coincidence of a back-propagating AP and distal synaptic input.
Model Type: Dendrite
Cell Type(s): Neocortex L5/6 pyramidal GLU cell
Currents: I Na,t; I A; I K; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; Ca pump
Model Concept(s): Dendritic Action Potentials
Simulation Environment: NEURON
Implementer(s): Korngreen, Alon [alon.korngreen at gmail.com]
References:
Almog M, Korngreen A. (2014). A Quantitative Description of Dendritic Conductances and Its Application to Dendritic Excitation in Layer 5 Pyramidal Neurons The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]