Yu Y, Shu Y, McCormick DA. (2008). Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

See more from authors: Yu Y · Shu Y · McCormick DA

References and models cited by this paper

Anderson JS, Lampl I, Gillespie DC, Ferster D. (2000). The contribution of noise to contrast invariance of orientation tuning in cat visual cortex. Science (New York, N.Y.). 290 [PubMed]

Astman N, Gutnick MJ, Fleidervish IA. (2006). Persistent sodium current in layer 5 neocortical neurons is primarily generated in the proximal axon. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Azmitia EC, Gannon PJ, Kheck NM, Whitaker-Azmitia PM. (1996). Cellular localization of the 5-HT1A receptor in primate brain neurons and glial cells. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 14 [PubMed]

Azouz R, Gray CM. (1999). Cellular mechanisms contributing to response variability of cortical neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Azouz R, Gray CM. (2000). Dynamic spike threshold reveals a mechanism for synaptic coincidence detection in cortical neurons in vivo. Proceedings of the National Academy of Sciences of the United States of America. 97 [PubMed]

Azouz R, Gray CM. (2003). Adaptive coincidence detection and dynamic gain control in visual cortical neurons in vivo. Neuron. 37 [PubMed]

Black JA, Kocsis JD, Waxman SG. (1990). Ion channel organization of the myelinated fiber. Trends in neurosciences. 13 [PubMed]

COOMBS JS, CURTIS DR, ECCLES JC. (1957). The generation of impulses in motoneurones. The Journal of physiology. 139 [PubMed]

Colbert CM, Johnston D. (1996). Axonal action-potential initiation and Na+ channel densities in the soma and axon initial segment of subicular pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Colbert CM, Pan E. (2002). Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nature neuroscience. 5 [PubMed]

Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ. (2001). Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons. Neuroscience. 107 [PubMed]

Destexhe A, Rudolph M, Paré D. (2003). The high-conductance state of neocortical neurons in vivo. Nature reviews. Neuroscience. 4 [PubMed]

Fricker D, Verheugen JA, Miles R. (1999). Cell-attached measurements of the firing threshold of rat hippocampal neurones. The Journal of physiology. 517 ( Pt 3) [PubMed]

Gutkin B, Ermentrout GB. (2006). Neuroscience: spikes too kinky in the cortex? Nature. 440 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

Henze DA, Buzsáki G. (2001). Action potential threshold of hippocampal pyramidal cells in vivo is increased by recent spiking activity. Neuroscience. 105 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Hoffman DA, Magee JC, Colbert CM, Johnston D. (1997). K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature. 387 [PubMed]

Howard A, Tamas G, Soltesz I. (2005). Lighting the chandelier: new vistas for axo-axonic cells. Trends in neurosciences. 28 [PubMed]

Inda MC, DeFelipe J, Muñoz A. (2006). Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells. Proceedings of the National Academy of Sciences of the United States of America. 103 [PubMed]

Kole MH et al. (2008). Action potential generation requires a high sodium channel density in the axon initial segment. Nature neuroscience. 11 [PubMed]

Kole MH, Letzkus JJ, Stuart GJ. (2007). Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. Neuron. 55 [PubMed]

Komada M, Soriano P. (2002). [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. The Journal of cell biology. 156 [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ. (1995). A model of spike initiation in neocortical pyramidal neurons. Neuron. 15 [PubMed]

Mainen ZF, Sejnowski TJ. (1995). Reliability of spike timing in neocortical neurons. Science (New York, N.Y.). 268 [PubMed]

Mainen ZF, Sejnowski TJ. (1996). Influence of dendritic structure on firing pattern in model neocortical neurons. Nature. 382 [PubMed]

McCormick DA, Huguenard JR. (1992). A model of the electrophysiological properties of thalamocortical relay neurons. Journal of neurophysiology. 68 [PubMed]

McCormick DA, Shu Y, Yu Y. (2007). Neurophysiology: Hodgkin and Huxley model--still standing? Nature. 445 [PubMed]

Migliore M, Hoffman DA, Magee JC, Johnston D. (1999). Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. Journal of computational neuroscience. 7 [PubMed]

Naundorf B, Wolf F, Volgushev M. (2006). Unique features of action potential initiation in cortical neurons. Nature. 440 [PubMed]

Neher E. (1992). Correction for liquid junction potentials in patch clamp experiments. Methods in enzymology. 207 [PubMed]

Nowak LG, Sanchez-Vives MV, McCormick DA. (1997). Influence of low and high frequency inputs on spike timing in visual cortical neurons. Cerebral cortex (New York, N.Y. : 1991). 7 [PubMed]

Palmer LM, Stuart GJ. (2006). Site of action potential initiation in layer 5 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Paré D, Shink E, Gaudreau H, Destexhe A, Lang EJ. (1998). Impact of spontaneous synaptic activity on the resting properties of cat neocortical pyramidal neurons In vivo. Journal of neurophysiology. 79 [PubMed]

Poolos NP, Migliore M, Johnston D. (2002). Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nature neuroscience. 5 [PubMed]

Rudolph M, Pelletier JG, Paré D, Destexhe A. (2005). Characterization of synaptic conductances and integrative properties during electrically induced EEG-activated states in neocortical neurons in vivo. Journal of neurophysiology. 94 [PubMed]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA. (2007). Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of neurophysiology. 97 [PubMed]

Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA. (2003). Barrages of synaptic activity control the gain and sensitivity of cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA. (2006). Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature. 441 [PubMed]

Shu Y, Yu Y, Yang J, McCormick DA. (2007). Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Stuart G, Schiller J, Sakmann B. (1997). Action potential initiation and propagation in rat neocortical pyramidal neurons. The Journal of physiology. 505 ( Pt 3) [PubMed]

Stuart G, Spruston N, Sakmann B, Häusser M. (1997). Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends in neurosciences. 20 [PubMed]

Waxman SG. (1995). Voltage-gated ion channels in axons: localization, function, and development The Axon. Structure, Function and Pathophysiology.

Waxman SG, Ritchie JM. (1993). Molecular dissection of the myelinated axon. Annals of neurology. 33 [PubMed]

Wilent WB, Contreras D. (2005). Stimulus-dependent changes in spike threshold enhance feature selectivity in rat barrel cortex neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Wollner DA, Catterall WA. (1986). Localization of sodium channels in axon hillocks and initial segments of retinal ganglion cells. Proceedings of the National Academy of Sciences of the United States of America. 83 [PubMed]

References and models that cite this paper

Alle H, Roth A, Geiger JR. (2009). Energy-efficient action potentials in hippocampal mossy fibers. Science (New York, N.Y.). 325 [PubMed]

Bahl A, Stemmler MB, Herz AV, Roth A. (2012). Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data. Journal of neuroscience methods. 210 [PubMed]

Brette R. (2013). Sharpness of spike initiation in neurons explained by compartmentalization. PLoS computational biology. 9 [PubMed]

Casale AE, McCormick DA. (2011). Active action potential propagation but not initiation in thalamic interneuron dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA. (2011). Somatic membrane potential and Kv1 channels control spike repolarization in cortical axon collaterals and presynaptic boutons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Foutz TJ, Arlow RL, McIntyre CC. (2012). Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron. Journal of neurophysiology. 107 [PubMed]

Grossman N et al. (2013). The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials. Journal of computational neuroscience. 34 [PubMed]

Hay E, Schürmann F, Markram H, Segev I. (2013). Preserving axosomatic spiking features despite diverse dendritic morphology. Journal of neurophysiology. 109 [PubMed]

Hu W et al. (2009). Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nature neuroscience. 12 [PubMed]

Ju H, Hines ML, Yu Y. (2016). Cable energy function of cortical axons. Scientific reports. 6 [PubMed]

Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N. (2015). Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. eLife. 4 [PubMed]

López-Jury L, Meza RC, Brown MTC, Henny P, Canavier CC. (2018). Morphological and Biophysical Determinants of the Intracellular and Extracellular Waveforms in Nigral Dopaminergic Neurons: A Computational Study. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]

Michalikova M, Remme MW, Kempter R. (2017). Spikelets in Pyramidal Neurons: Action Potentials Initiated in the Axon Initial Segment That Do Not Activate the Soma. PLoS computational biology. 13 [PubMed]

Platkiewicz J, Brette R. (2010). A threshold equation for action potential initiation. PLoS computational biology. 6 [PubMed]

Platkiewicz J, Brette R. (2011). Impact of fast sodium channel inactivation on spike threshold dynamics and synaptic integration. PLoS computational biology. 7 [PubMed]

Singh C, Levy WB. (2017). A consensus layer V pyramidal neuron can sustain interpulse-interval coding. PloS one. 12 [PubMed]

Smith SL, Smith IT, Branco T, Häusser M. (2013). Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo. Nature. 503 [PubMed]

Telenczuk M, Fontaine B, Brette R. (2017). The basis of sharp spike onset in standard biophysical models. PloS one. 12 [PubMed]

Teleńczuk M, Brette R, Destexhe A, Teleńczuk B. (2018). Contribution of the Axon Initial Segment to Action Potentials Recorded Extracellularly. eNeuro. 5 [PubMed]

Öz P, Huang M, Wolf F. (2015). Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment. Journal of computational neuroscience. 39 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.