Goodliffe JW et al. (2018). Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PloS one. 13 [PubMed]

See more from authors: Goodliffe JW · Song H · Rubakovic A · Chang W · Medalla M · Weaver CM · Luebke JI

References and models cited by this paper

. (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell. 72 [PubMed]

Aizman O et al. (2000). Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons. Nature neuroscience. 3 [PubMed]

Akbergenova Y, Littleton JT. (2017). Pathogenic Huntington Alters BMP Signaling and Synaptic Growth through Local Disruptions of Endosomal Compartments. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]

Albin RL et al. (1992). Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease. Annals of neurology. 31 [PubMed]

Amatrudo JM et al. (2012). Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

André VM, Fisher YE, Levine MS. (2011). Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington's Disease. Frontiers in systems neuroscience. 5 [PubMed]

Ansari AM et al. (2016). Cellular GFP Toxicity and Immunogenicity: Potential Confounders in in Vivo Cell Tracking Experiments. Stem cell reviews and reports. 12 [PubMed]

Ariano MA et al. (2005). Striatal potassium channel dysfunction in Huntington's disease transgenic mice. Journal of neurophysiology. 93 [PubMed]

Ariano MA, Wagle N, Grissell AE. (2005). Neuronal vulnerability in mouse models of Huntington's disease: membrane channel protein changes. Journal of neuroscience research. 80 [PubMed]

Barry J, Akopian G, Cepeda C, Levine MS. (2018). Striatal Direct and Indirect Pathway Output Structures Are Differentially Altered in Mouse Models of Huntington's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]

Carnevale NT, Tsai KY, Claiborne BJ, Brown TH. (1994). Efficient mapping from neuroanatomical to electronic space Network. 5

Carnevale NT, Tsai KY, Claiborne BJ, Brown TH. (1997). Comparative electrotonic analysis of three classes of rat hippocampal neurons. Journal of neurophysiology. 78 [PubMed]

Cepeda C et al. (2008). Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons. The European journal of neuroscience. 27 [PubMed]

Cepeda C, Cummings DM, André VM, Holley SM, Levine MS. (2010). Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms. ASN neuro. 2 [PubMed]

Cepeda C et al. (2013). Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Cepeda C et al. (2003). Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Claiborne BJ, Brown TH, Mainen ZF, Zador AM. (1992). Hebbian computations in hippocampal dendrites and spines Single Neuron Computation.

Cleveland WS, Chambers JM, Kleiner B, Tukey PA. (1983). Graphical Methods for Data Analysis.

Coskren PJ et al. (2015). Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex. Journal of computational neuroscience. 38 [PubMed]

Deng YP et al. (2004). Differential loss of striatal projection systems in Huntington's disease: a quantitative immunohistochemical study. Journal of chemical neuroanatomy. 27 [PubMed]

Deng YP, Wong T, Wan JY, Reiner A. (2014). Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease. Frontiers in systems neuroscience. 8 [PubMed]

Dickey AS, La Spada AR. (2018). Therapy development in Huntington disease: From current strategies to emerging opportunities. American journal of medical genetics. Part A. 176 [PubMed]

Doig NM, Moss J, Bolam JP. (2010). Cortical and thalamic innervation of direct and indirect pathway medium-sized spiny neurons in mouse striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Et AL et al. (2014). XSEDE: Accelerating Scientific Discovery Comput Sci Eng. 16

Evans RC et al. (2012). The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS computational biology. 8 [PubMed]

Farde L et al. (1997). PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington’s disease Brain. 120

Gertler TS, Chan CS, Surmeier DJ. (2008). Dichotomous anatomical properties of adult striatal medium spiny neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Glass M, Dragunow M, Faull RL. (2000). The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. Neuroscience. 97 [PubMed]

Graveland GA, Williams RS, DiFiglia M. (1985). Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease. Science (New York, N.Y.). 227 [PubMed]

Haddad MS, Cummings JL. (1997). Huntington's disease. The Psychiatric clinics of North America. 20 [PubMed]

Hall AM et al. (2015). Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Heikkinen T et al. (2012). Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease. PloS one. 7 [PubMed]

Hines ML, Carnevale NT. (2006). The NEURON Book.

Hines ML, Morse T, Migliore M, Carnevale NT, Shepherd GM. (2004). ModelDB: A Database to Support Computational Neuroscience. Journal of computational neuroscience. 17 [PubMed]

Huerta-Ocampo I, Mena-Segovia J, Bolam JP. (2014). Convergence of cortical and thalamic input to direct and indirect pathway medium spiny neurons in the striatum. Brain structure & function. 219 [PubMed]

Indersmitten T, Tran CH, Cepeda C, Levine MS. (2015). Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease. Journal of neurophysiology. 113 [PubMed]

Ionis Pharmaceuticals. (2018). Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS-HTTRx in Patients With Early Manifest Huntington’s Disease ClinicalTrials.gov.

Jensen EC. (2012). Use of fluorescent probes: their effect on cell biology and limitations. Anatomical record (Hoboken, N.J. : 2007). 295 [PubMed]

Joyce JN, Lexow N, Bird E, Winokur A. (1988). Organization of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntington’s disease and schizophrenia Synapse. 2

Kabaso D, Coskren PJ, Henry BI, Hof PR, Wearne SL. (2009). The electrotonic structure of pyramidal neurons contributing to prefrontal cortical circuits in macaque monkeys is significantly altered in aging. Cerebral cortex (New York, N.Y. : 1991). 19 [PubMed]

Kawaguchi Y, Wilson CJ, Emson PC. (1990). Projection subtypes of rat neostriatal matrix cells revealed by intracellular injection of biocytin. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10 [PubMed]

Kay C, Skotte NH, Southwell AL, Hayden MR. (2014). Personalized gene silencing therapeutics for Huntington disease. Clinical genetics. 86 [PubMed]

Kemp JM, Powell TP. (1971). The termination of fibres from the cerebral cortex and thalamus upon dendritic spines in the caudate nucleus: a study with the Golgi method. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 262 [PubMed]

Klapstein GJ et al. (2001). Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice. Journal of neurophysiology. 86 [PubMed]

Kumar A et al. (2017). Fluorescent proteins such as eGFP lead to catalytic oxidative stress in cells Redox Biol. 2

Langfelder P et al. (2016). Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nature neuroscience. 19 [PubMed]

Luebke JI, Rosene DL. (2003). Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey. The Journal of comparative neurology. 460 [PubMed]

McColgan P, Tabrizi SJ. (2018). Huntington's disease: a clinical review. European journal of neurology. 25 [PubMed]

Medalla M, Gilman JP, Wang JY, Luebke JI. (2017). Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]

Medalla M, Luebke JI. (2015). Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Menalled LB et al. (2012). Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175. PloS one. 7 [PubMed]

Nakamura T et al. (2014). Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior. Frontiers in integrative neuroscience. 8 [PubMed]

Niccolini F et al. (2018). Striatal molecular alterations in HD gene carriers: a systematic review and meta-analysis of PET studies. Journal of neurology, neurosurgery, and psychiatry. 89 [PubMed]

Plotkin JL et al. (2014). Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease. Neuron. 83 [PubMed]

Rall W. (1969). Time constants and electrotonic length of membrane cylinders and neurons. Biophysical journal. 9 [PubMed]

Raymond LA. (2017). Striatal synaptic dysfunction and altered calcium regulation in Huntington disease. Biochemical and biophysical research communications. 483 [PubMed]

Reiner A et al. (1988). Differential loss of striatal projection neurons in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. 85 [PubMed]

Richfield EK, Maguire-Zeiss KA, Cox C, Gilmore J, Voorn P. (1995). Reduced expression of preproenkephalin in striatal neurons from Huntington's disease patients. Annals of neurology. 37 [PubMed]

Richfield EK, Maguire-Zeiss KA, Vonkeman HE, Voorn P. (1995). Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients. Annals of neurology. 38 [PubMed]

Rocher AB et al. (2016). Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease. Neurobiology of disease. 86 [PubMed]

Rosas HD et al. (2006). Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures. Movement disorders : official journal of the Movement Disorder Society. 21 [PubMed]

Rumbell TH et al. (2016). Automated evolutionary optimization of ion channel conductances and kinetics in models of young and aged rhesus monkey pyramidal neurons. Journal of computational neuroscience. 41 [PubMed]

Schneider CA, Rasband WS, Eliceiri KW. (2012). NIH Image to ImageJ: 25 years of image analysis. Nature methods. 9 [PubMed]

Sebastianutto I, Cenci MA, Fieblinger T. (2017). Alterations of striatal indirect pathway neurons precede motor deficits in two mouse models of Huntington's disease. Neurobiology of disease. 105 [PubMed]

Smith GS et al. (1998). Glutamate modulation of dopamine measured in vivo with positron emission tomography (PET) and 11C-raclopride in normal human subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 18 [PubMed]

Southwell AL et al. (2016). An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes. Human molecular genetics. 25 [PubMed]

Surmeier DJ, Song WJ, Yan Z. (1996). Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Tomkins A, Vasilaki E, Beste C, Gurney K, Humphries MD. (2013). Transient and steady-state selection in the striatal microcircuit. Frontiers in computational neuroscience. 7 [PubMed]

Turjanski N, Weeks R, Dolan R, Harding AE, Brooks DJ. (1995). Striatal D1 and D2 receptor binding in patients with Huntington's disease and other choreas. A PET study. Brain : a journal of neurology. 118 ( Pt 3) [PubMed]

Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. (2015). Neural precursor lineages specify distinct neocortical pyramidal neuron types. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Vonsattel JP, DiFiglia M. (1998). Huntington disease. Journal of neuropathology and experimental neurology. 57 [PubMed]

Vonsattel JP et al. (1985). Neuropathological classification of Huntington's disease. Journal of neuropathology and experimental neurology. 44 [PubMed]

Wilson H, De Micco R, Niccolini F, Politis M. (2017). Molecular Imaging Markers to Track Huntington's Disease Pathology. Frontiers in neurology. 8 [PubMed]

Wolf JA et al. (2005). NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Wyant KJ, Ridder AJ, Dayalu P. (2017). Huntington's Disease-Update on Treatments. Current neurology and neuroscience reports. 17 [PubMed]

Zheng P, Kozloski J. (2017). Striatal Network Models of Huntington's Disease Dysfunction Phenotypes. Frontiers in computational neuroscience. 11 [PubMed]

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Reed JD, Blackwell KT. (2021). Prediction of Neural Diameter From Morphology to Enable Accurate Simulation. Frontiers in neuroinformatics. 15 [PubMed]

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