Model files in the NEURON simulation environment (v7.5) from the paper:

The subthreshold-active Kv7 current limits spike-induced Ca2+ influx in hippocampal mossy fiber synaptic terminals to regulate neurotransmission.”

By Katiuscia Martinello , Elisabetta Giacalone , Michele Migliore , David A. Brown and Mala M. Shah

Communications Biology, 2019

Auto-launch from ModelDB or:

Compile the mod files with mknrndll (mswin or graphical mac) or nrnivmodl (unix/linux)). Start the simulation by (unix/linux) typing on the command line:

nrngui mosinit.hoc

or (mac os x) drag and dropping the mosinit.hoc file on the nrngui icon or (mswin) double clicking on the mosinit.hoc file.

Select “Single AP” or “50 Hz train” to reproduce respectively figures 4b,c and d of the paper.

The simulations will reproduce functional effects of Km removal in mossy fiber boutons.

After you press the "Single AP" button you should see images like these:

and after you press "50 Hz train" you should see the below:

If you need more help running the model on your platform, please consult this page:

https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml