Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)


Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM. (2010). Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Frontiers in neural circuits. 4 [PubMed]

See more from authors: Morse TM · Carnevale NT · Mutalik PG · Migliore M · Shepherd GM

References and models cited by this paper

Acker CD, White JA. (2007). Roles of IA and morphology in action potential propagation in CA1 pyramidal cell dendrites. Journal of computational neuroscience. 23 [PubMed]

Anderton BH et al. (1998). Dendritic changes in Alzheimer's disease and factors that may underlie these changes. Progress in neurobiology. 55 [PubMed]

Andrásfalvy BK, Makara JK, Johnston D, Magee JC. (2008). Altered synaptic and non-synaptic properties of CA1 pyramidal neurons in Kv4.2 knockout mice. The Journal of physiology. 586 [PubMed]

Canepari M, Djurisic M, Zecevic D. (2007). Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre- and post-synaptic activity: a combined voltage- and calcium-imaging study. The Journal of physiology. 580 [PubMed]

Chen C. (2005). beta-Amyloid increases dendritic Ca2+ influx by inhibiting the A-type K+ current in hippocampal CA1 pyramidal neurons. Biochemical and biophysical research communications. 338 [PubMed]

Colbert CM, Magee JC, Hoffman DA, Johnston D. (1997). Slow recovery from inactivation of Na+ channels underlies the activity-dependent attenuation of dendritic action potentials in hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Demont-Guignard S, Benquet P, Gerber U, Wendling F. (2009). Analysis of intracerebral EEG recordings of epileptic spikes: insights from a neural network model. IEEE transactions on bio-medical engineering. 56 [PubMed]

Disterhoft JF, Oh MM, Oliveira FA. (2010). Learning and aging related changes in intrinsic neuronal excitability Frontiers In Aging Neuroscien. 2(1)

Fisher RE, Gray R, Johnston D. (1990). Properties and distribution of single voltage-gated calcium channels in adult hippocampal neurons. Journal of neurophysiology. 64 [PubMed]

Frick A, Magee J, Koester HJ, Migliore M, Johnston D. (2003). Normalization of Ca2+ signals by small oblique dendrites of CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Gasparini S, Losonczy A, Chen X, Johnston D, Magee JC. (2007). Associative pairing enhances action potential back-propagation in radial oblique branches of CA1 pyramidal neurons. The Journal of physiology. 580 [PubMed]

Golding NL, Kath WL, Spruston N. (2001). Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites. Journal of neurophysiology. 86 [PubMed]

Golding NL, Mickus TJ, Katz Y, Kath WL, Spruston N. (2005). Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites. The Journal of physiology. 568 [PubMed]

Golomb D, Yue C, Yaari Y. (2006). Contribution of persistent Na+ current and M-type K+ current to somatic bursting in CA1 pyramidal cells: combined experimental and modeling study. Journal of neurophysiology. 96 [PubMed]

Good TA, Murphy RM. (1996). Effect of beta-amyloid block of the fast-inactivating K+ channel on intracellular Ca2+ and excitability in a modeled neuron. Proceedings of the National Academy of Sciences of the United States of America. 93 [PubMed]

Gulledge AT, Kampa BM, Stuart GJ. (2005). Synaptic integration in dendritic trees. Journal of neurobiology. 64 [PubMed]

Helmchen F, Imoto K, Sakmann B. (1996). Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons. Biophysical journal. 70 [PubMed]

Hemond P et al. (2008). Distinct classes of pyramidal cells exhibit mutually exclusive firing patterns in hippocampal area CA3b. Hippocampus. 18 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Hines ML, Morse TM, Carnevale NT. (2007). Model structure analysis in NEURON : toward interoperability among neural simulators. Methods in molecular biology (Clifton, N.J.). 401 [PubMed]

Hoffman DA, Magee JC, Colbert CM, Johnston D. (1997). K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature. 387 [PubMed]

Jaffe DB et al. (1994). A model for dendritic Ca2+ accumulation in hippocampal pyramidal neurons based on fluorescence imaging measurements. Journal of neurophysiology. 71 [PubMed]

Jarsky T, Roxin A, Kath WL, Spruston N. (2005). Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons. Nature neuroscience. 8 [PubMed]

Jhamandas JH et al. (2001). Cellular mechanisms for amyloid beta-protein activation of rat cholinergic basal forebrain neurons. Journal of neurophysiology. 86 [PubMed]

Johnston D, Hoffman DA, Colbert CM, Magee JC. (1999). Regulation of back-propagating action potentials in hippocampal neurons. Current opinion in neurobiology. 9 [PubMed]

Jung SC, Kim J, Hoffman DA. (2008). Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons. Neuron. 60 [PubMed]

Kamondi A, Acsády L, Buzsáki G. (1998). Dendritic spikes are enhanced by cooperative network activity in the intact hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Katz Y et al. (2009). Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons. Neuron. 63 [PubMed]

Khachaturian ZS. (1987). Hypothesis on the regulation of cytosol calcium concentration and the aging brain. Neurobiology of aging. 8 [PubMed]

Kim J, Wei DS, Hoffman DA. (2005). Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones. The Journal of physiology. 569 [PubMed]

Larkum ME, Nevian T, Sandler M, Polsky A, Schiller J. (2009). Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. Science (New York, N.Y.). 325 [PubMed]

Liao CW, Lien CC. (2009). Estimating intracellular Ca2+ concentrations and buffering in a dendritic inhibitory hippocampal interneuron. Neuroscience. 164 [PubMed]

London M, Meunier C, Segev I. (1999). Signal transfer in passive dendrites with nonuniform membrane conductance. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Losonczy A, Makara JK, Magee JC. (2008). Compartmentalized dendritic plasticity and input feature storage in neurons. Nature. 452 [PubMed]

Lue LF et al. (1999). Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. The American journal of pathology. 155 [PubMed]

Magee JC, Cook EP. (2000). Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature neuroscience. 3 [PubMed]

Maravall M, Mainen ZF, Sabatini BL, Svoboda K. (2000). Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophysical journal. 78 [PubMed]

Metz AE, Jarsky T, Martina M, Spruston N. (2005). R-type calcium channels contribute to afterdepolarization and bursting in hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Mickus T, Jung Hy, Spruston N. (1999). Properties of slow, cumulative sodium channel inactivation in rat hippocampal CA1 pyramidal neurons. Biophysical journal. 76 [PubMed]

Migliore M, Ferrante M, Ascoli GA. (2005). Signal propagation in oblique dendrites of CA1 pyramidal cells. Journal of neurophysiology. 94 [PubMed]

Migliore M, Hoffman DA, Magee JC, Johnston D. (1999). Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. Journal of computational neuroscience. 7 [PubMed]

Omori T, Aonishi T, Miyakawa H, Inoue M, Okada M. (2006). Estimated distribution of specific membrane resistance in hippocampal CA1 pyramidal neuron. Brain research. 1125 [PubMed]

Omori T, Aonishi T, Miyakawa H, Inoue M, Okada M. (2009). Steep decrease in the specific membrane resistance in the apical dendrites of hippocampal CA1 pyramidal neurons. Neuroscience research. 64 [PubMed]

Scheibel AB. (1979). The hippocampus: organizational patterns in health and senescence. Mechanisms of ageing and development. 9 [PubMed]

Shepherd GM, Byrne JH. (2009). Complex information processing in dendrites From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience.

Sjöström PJ, Rancz EA, Roth A, Häusser M. (2008). Dendritic excitability and synaptic plasticity. Physiological reviews. 88 [PubMed]

Song D, Wang Z, Berger TW. (2002). Contribution of T-type VDCC to TEA-induced long-term synaptic modification in hippocampal CA1 and dentate gyrus. Hippocampus. 12 [PubMed]

Spruston N, Hausser M, Stuart GJ. (2008). Dendrites.

Spruston N, Schiller Y, Stuart G, Sakmann B. (1995). Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science (New York, N.Y.). 268 [PubMed]

Stutzmann GE. (2007). The pathogenesis of Alzheimers disease is it a lifelong "calciumopathy"? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 13 [PubMed]

Ueda K, Shinohara S, Yagami T, Asakura K, Kawasaki K. (1997). Amyloid beta protein potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels: a possible involvement of free radicals. Journal of neurochemistry. 68 [PubMed]

Urakubo H, Aihara T, Kuroda S, Watanabe M, Kondo S. (2004). Spatial localization of synapses required for supralinear summation of action potentials and EPSPs. Journal of computational neuroscience. 16 [PubMed]

Varga AW, Anderson AE, Adams JP, Vogel H, Sweatt JD. (2000). Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain. Learning & memory (Cold Spring Harbor, N.Y.). 7 [PubMed]

Wang J, Ikonen S, Gurevicius K, Van Groen T, Tanila H. (2003). Altered auditory-evoked potentials in mice carrying mutated human amyloid precursor protein and presenilin-1 transgenes. Neuroscience. 116 [PubMed]

Watanabe S, Hoffman DA, Migliore M, Johnston D. (2002). Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 99 [PubMed]

Xu C et al. (1998). Effects of beta-amyloid peptide on transient outward potassium current of acutely dissociated hippocampal neurons in CA1 sector in rats. Chinese medical journal. 111 [PubMed]

Ye CP, Selkoe DJ, Hartley DM. (2003). Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures. Neurobiology of disease. 13 [PubMed]

Yue C, Yaari Y. (2004). KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Zhang CF, Yang P. (2006). Zinc-induced aggregation of Abeta (10-21) potentiates its action on voltage-gated potassium channel. Biochemical and biophysical research communications. 345 [PubMed]

References and models that cite this paper

Culmone V, Migliore M. (2012). Progressive effect of beta amyloid peptides accumulation on CA1 pyramidal neurons: a model study suggesting possible treatments. Frontiers in computational neuroscience. 6 [PubMed]

McDougal RA, Dalal I, Morse TM, Shepherd GM. (2019). Automated Metadata Suggestion During Repository Submission. Neuroinformatics. 17 [PubMed]

McDougal RA, Morse TM, Hines ML, Shepherd GM. (2015). ModelView for ModelDB: Online Presentation of Model Structure. Neuroinformatics. 13 [PubMed]

Romani A et al. (2013). Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses. Frontiers in computational neuroscience. 7 [PubMed]

Zou X, Coyle D, Wong-Lin K, Maguire L. (2011). Computational study of hippocampal-septal theta rhythm changes due to ß-amyloid-altered ionic channels. PloS one. 6 [PubMed]

Zou X, Coyle D, Wong-Lin K, Maguire L. (2012). Beta-amyloid induced changes in A-type K? current can alter hippocampo-septal network dynamics. Journal of computational neuroscience. 32 [PubMed]

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