    NEURON files from the paper:

    Learning mechanism for column formation in the olfactory bulb
    by M. Migliore, Carlo Inzirillo, Gordon M. Shepherd,
    Front. Integr. Neurosci. (2007) 1:12. doi:10.3389/neuro.07.012.2007

    In the olfactory bulb, the processing units for odor discrimination
    are believed to involve dendrodendritic synaptic interactions between
    mitral and granule cells.  There is increasing anatomical evidence
    that these cells are organized in columns, and that the columns
    processing a given odor are arranged in widely distributed arrays.
    Experimental evidence is lacking on the underlying learning mechanisms
    for how these columns and arrays are formed.  We have used a
    simplified realistic circuit model to test the hypothesis that
    distributed connectivity can self-organize through an
    activity-dependent dendrodendritic synaptic mechanism.  The results
    point to action potentials propagating in the mitral cell lateral
    dendrites as playing a critical role in this mechanism, and suggest a
    novel and robust learning mechanism for the development of distributed
    processing units in a cortical structure.

    The traces shown in Fig.2 of the paper are produced by running
    2mc-w05-w00-e2i3-int220.hoc.  However, because the simulation is quite
    long, the output files are included in the distribution and read by
    plasticity-disp.hoc, that also allows the display of the time course
    for all dendrodendritic synapses.

    After the fig 2 button is pressed and the simulations have completed,
    the windows can have there axes adjusted similarly to the figures:

    Under unix systems:
    to compile the mod files use the command
    nrnivmodl
    and run the simulation hoc file with the command
    nrngui mosinit.hoc

    Under Windows systems:
    to compile the mod files use the "mknrndll" command.
    A double click on the simulation file
    mosinit.hoc
    will open the simulation window.

    Under MAC OS X:

    Drag and drop the plast folder onto the mknrndll icon in the NEURON
    application folder.  When the mod files are finished compiling drag
    and drop the mosinit.hoc file onto the nrngui icon.

    Questions on how to use this model
    should be directed to michele.migliore@pa.ibf.cnr.it