    This is the readme for the models associated with the paper

    Peter Jedlicka, Thomas Deller, Boris S. Gutkin, Kurt H. Backus (2011)
    Activity-dependent intracellular chloride accumulation and diffusion
    controls GABAA receptor-mediated synaptic transmission
    Hippocampus 21:885-898.

    Send bug reports, comments and questions on how to use this model to
    jedlicka@em.uni-frankfurt.de/mohapatra@em.uni-frankfurt.de

    The code for 8 granule cell morphologies and passive properties was
    taken from Schmidt-Hieber et al. 2007:
    http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=95960
    See their readme file for the description of .hoc files in the ./share
    and ./cell_x folders.

    Usage:

    1. Download and install NEURON (available from
    http://www.neuron.yale.edu/neuron/download)

    2. Compile the NEURON mod files:

    	mswin: run mknrndll and select this folder to create the
    	       nrnmech.dll
    	linux: run nrnivmodl in this folder
    	mac os x: drag and drop this folder onto mknrndll

    3. Start the simulations:

    	Figure 6 simulation - EGABA shift following activation of
    	multiple GABAA synapses:

    	-------------------------------------------------------------

    	mswin: double click the mosinit.hoc file using windows
                   explorer
    	linux: type "nrngui mosinit.hoc" in the shell prompt in this
    	       folder
    	mac os x: drag and drop the mosinit.hoc file onto the nrngui
                      icon

    	To run the simulation click on Init & Run button.

    	The simulation automatically executes stochastic activation of
    	multiple dendritic and somatic GABA-A synapses with mean
    	frequency of 10 Hz/synapse. The simulation starts running and
    	begins to generate a shape plot of the granule cell, with
    	colour code indicating EGABA changes. The simulation
    	reproduces Figure 6A of the paper, but since the synapses are
    	activated randomly, each run's result is unique.  Zooming in
            on one of the simulation generated figures should look like:

    	- Note: Default cell morphology is cell_7.  This can be
    	changed in the ./share/controlpanelGC.hoc file by changing
    	defaultCellIndex variable (ranging from 0 to 7).

    	Figure 7 simulation - EGABA shift following activation of a
            single GABAA synapse:

    ---------------------------------------------------------------------

            mswin: double click the mosinit_single.hoc file using windows
                   explorer
            linux: type "nrngui mosinit_single.hoc" in the shell prompt in
                   this folder
            mac os x: drag and drop the mosinit_single.hoc file onto the
                      nrngui icon

    	To run the simulation click on Init & Run button.

    	The simulation automatically executes stochastic activation of
    	a single dendritic GABA-A input with mean frequency of 40
    	Hz. The simulation starts running and begins to generate a
    	shape plot of the granule cell, with colour code indicating
    	EGABA changes.

    	- Note: Default location of the synapse is in the middle of a
    	dendrite.  This can be changed in the
    	./init_ClmIPSCs_GC_single.hoc file by setting
    	DISTAL_SIMULATION = 1 (to move the synapse to the distal end
    	of the dendrite).

    	For further simulation parameters please refer to the paper.

    Description of mod files:

    ./cldifus.mod           Chloride radial/longitudinal diffusion and
    			accumulation mechanism with chloride extrusion
    			mechanism mediating exponential recovery of
    			intracellular chloride concentration to
    			resting chloride level.

    ./cldifus2.mod          Chloride radial/longitudinal diffusion and
    			accumulation mechanism with chloride pump
    			(Lineweaver-Burke equation) and chloride leak.
    			Not used in Fig6/7 simulations.

    ./gabaA_Cl.mod          Ohmic synaptic GABAergic mechanism with
                            dynamic GABA reversal.

    ./gaghk.mod             GHK synaptic GABAergic mechanism with dynamic
    			GABA reversal.  Not used in Fig6/7
    			simulations.