Model files in the NEURON simulation environment (v8.0) from the paper

Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs

by D. Bianchi, R. Migliore, P. Vitale, M. Garad, P.A. Pousinha, H. Marie, V. Lessmann, M. Migliore

https://doi.org/10.1016/j.bpj.2022.01.002

Usage:

Auto-launch from ModelDB or:

Compile the mod files with mknrndll (mswin or graphical mac) or

nrnivmodl (unix/linux)). Start the simulation by (unix/linux) typing

on the command line:

nrngui fig5_Lab1_main.hoc

or (mac os x) drag and dropping the fig5_Lab1_main.hoc file on the nrngui icon or (mswin) double clicking on the fig5_Lab1_main.hoc file.

After selecting the experimental current from laboratory 1 you wish to visualize and the corresponding input current, simulation will reproduce the (non-filtered) somatic membrane potential like in fig5 of the paper (black traces).

Example:

Questions on how to use this model should be directed to rosanna.migliore@cnr.it

All electrophysiological traces used for the models are available at the Human Brain collab https://live-papers.brainsimulation.eu/

Access to this resource requires free user registration at https://www.humanbrainproject.eu/en/hbp-platforms/getting-access/