:: Documentation: https://github.com/fietkiewicz/PointerBuilder
:: Description: Muscle force calculation.
:: Notes:
:: The model is adapted from the following paper:
:: Kim H. Linking Motoneuron PIC Location to Motor Function in Closed-Loop Motor Unit System Including Afferent
:: Feedback: A Computational Investigation. eNeuro. 2020 Apr 27;7(2)
:: On ModelDB: https://modeldb.science/266732
NEURON {
POINT_PROCESS force
POINTER aPointer, xmPointer
RANGE a0, b0, c0, d0
RANGE p0, g1, g2, g3
RANGE Kse, A, Fc, F
RANGE xm_init, xce_init, xce
RANGE spk_index, t_axon
}
PARAMETER {
a0 = 2.35 :[N]
b0 = 24.35 :[mm*s-1]
c0 = -7.4 :[N]
d0 = 30.3 :[mm*s-1]
p0 = 23 :[N]
g1 = -8 :[mm]
g2 = 21.4 :[mm]
xm_init = -8 :[mm]
xce_init = -8 :[mm]
Kse = 0.4 :[mm-1]
}
STATE {
xce
}
ASSIGNED {
aPointer
xmPointer
F
Fc
}
BREAKPOINT { LOCAL i
SOLVE state METHOD cnexp
F = p0*Kse*xse(xmPointer, xce)
}
DERIVATIVE state {
Fc = p0*g(xmPointer)*aPointer
xce' = dxdt (F, Fc)
}
FUNCTION xse (x, y) { LOCAL d_xm, d_xce, d_se
d_xm = xmPointer - xm_init
d_xce = xce - xce_init
d_se = d_xm - d_xce
if (d_se <= 0) {xse = 0}
else {xse = d_se}
}
FUNCTION g (x) {
g = exp(-((x-g1)/g2)^2)
}
FUNCTION dxdt (x, xc) {LOCAL gain_length
if (x <= xc) {
dxdt = (10^-3)*(-b0*(xc-x))/(x+a0*xc/p0)
} else {
gain_length = (-d0*(xc-x))/(2*xc-x+c0*xc/p0)
if (gain_length <= 0) {dxdt = (10^-3)*1e5}
else {dxdt = (10^-3)*gain_length}
}
}
INITIAL {
xce = xce_init
F = 1e-5
}