/* Created by Language version: 6.2.0 */
/* NOT VECTORIZED */
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define _threadargscomma_ /**/
#define _threadargs_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargsproto_ /**/
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define gbar _p[0]
#define g _p[1]
#define C1 _p[2]
#define C2 _p[3]
#define C3 _p[4]
#define C4 _p[5]
#define C5 _p[6]
#define I1 _p[7]
#define I2 _p[8]
#define I3 _p[9]
#define I4 _p[10]
#define I5 _p[11]
#define O _p[12]
#define I6 _p[13]
#define f01 _p[14]
#define f02 _p[15]
#define f03 _p[16]
#define f04 _p[17]
#define f0O _p[18]
#define f11 _p[19]
#define f12 _p[20]
#define f13 _p[21]
#define f14 _p[22]
#define f1n _p[23]
#define fi1 _p[24]
#define fi2 _p[25]
#define fi3 _p[26]
#define fi4 _p[27]
#define fi5 _p[28]
#define fin _p[29]
#define b01 _p[30]
#define b02 _p[31]
#define b03 _p[32]
#define b04 _p[33]
#define b0O _p[34]
#define b11 _p[35]
#define b12 _p[36]
#define b13 _p[37]
#define b14 _p[38]
#define b1n _p[39]
#define bi1 _p[40]
#define bi2 _p[41]
#define bi3 _p[42]
#define bi4 _p[43]
#define bi5 _p[44]
#define bin _p[45]
#define ena _p[46]
#define ina _p[47]
#define DC1 _p[48]
#define DC2 _p[49]
#define DC3 _p[50]
#define DC4 _p[51]
#define DC5 _p[52]
#define DI1 _p[53]
#define DI2 _p[54]
#define DI3 _p[55]
#define DI4 _p[56]
#define DI5 _p[57]
#define DO _p[58]
#define DI6 _p[59]
#define _g _p[60]
#define _ion_ena *_ppvar[0]._pval
#define _ion_ina *_ppvar[1]._pval
#define _ion_dinadv *_ppvar[2]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
extern double celsius;
/* declaration of user functions */
static void _hoc_rates(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_p = _prop->param; _ppvar = _prop->dparam;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_NaV", _hoc_setdata,
"rates_NaV", _hoc_rates,
0, 0
};
/* declare global and static user variables */
#define Coff Coff_NaV
double Coff = 40;
#define Con Con_NaV
double Con = 0.01;
#define Ooff Ooff_NaV
double Ooff = 0.05;
#define Oon Oon_NaV
double Oon = 8;
#define alfac alfac_NaV
double alfac = 2.51;
#define alpha alpha_NaV
double alpha = 400;
#define btfac btfac_NaV
double btfac = 5.32;
#define beta beta_NaV
double beta = 12;
#define delta delta_NaV
double delta = 60;
#define gamma gamma_NaV
double gamma = 250;
#define x2 x2_NaV
double x2 = -24;
#define x1 x1_NaV
double x1 = 24;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"Con_NaV", "/ms",
"Coff_NaV", "/ms",
"Oon_NaV", "/ms",
"Ooff_NaV", "/ms",
"alpha_NaV", "/ms",
"beta_NaV", "/ms",
"gamma_NaV", "/ms",
"delta_NaV", "/ms",
"x1_NaV", "mV",
"x2_NaV", "mV",
"gbar_NaV", "S/cm2",
"g_NaV", "S/cm2",
0,0
};
static double C50 = 0;
static double C40 = 0;
static double C30 = 0;
static double C20 = 0;
static double C10 = 0;
static double I60 = 0;
static double I50 = 0;
static double I40 = 0;
static double I30 = 0;
static double I20 = 0;
static double I10 = 0;
static double O0 = 0;
static double delta_t = 0.01;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"Con_NaV", &Con_NaV,
"Coff_NaV", &Coff_NaV,
"Oon_NaV", &Oon_NaV,
"Ooff_NaV", &Ooff_NaV,
"alpha_NaV", &alpha_NaV,
"beta_NaV", &beta_NaV,
"gamma_NaV", &gamma_NaV,
"delta_NaV", &delta_NaV,
"alfac_NaV", &alfac_NaV,
"btfac_NaV", &btfac_NaV,
"x1_NaV", &x1_NaV,
"x2_NaV", &x2_NaV,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[3]._i
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"6.2.0",
"NaV",
"gbar_NaV",
0,
"g_NaV",
0,
"C1_NaV",
"C2_NaV",
"C3_NaV",
"C4_NaV",
"C5_NaV",
"I1_NaV",
"I2_NaV",
"I3_NaV",
"I4_NaV",
"I5_NaV",
"O_NaV",
"I6_NaV",
0,
0};
static Symbol* _na_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 61, _prop);
/*initialize range parameters*/
gbar = 0.015;
_prop->param = _p;
_prop->param_size = 61;
_ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_na_sym);
nrn_promote(prop_ion, 0, 1);
_ppvar[0]._pval = &prop_ion->param[0]; /* ena */
_ppvar[1]._pval = &prop_ion->param[3]; /* ina */
_ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dinadv */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*f)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _NaV_reg() {
int _vectorized = 0;
_initlists();
ion_reg("na", -10000.);
_na_sym = hoc_lookup("na_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 0);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
hoc_register_prop_size(_mechtype, 61, 4);
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 NaV /home/ramcdougal/temp/abi3/models/473561660/x86_64/NaV.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "Mouse sodium current";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rates(double);
extern double *_getelm();
#define _MATELM1(_row,_col) *(_getelm(_row + 1, _col + 1))
#define _RHS1(_arg) _coef1[_arg + 1]
static double *_coef1;
#define _linmat1 1
static void* _sparseobj1;
static void* _cvsparseobj1;
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
#define _RHS2(arg) _coef2[arg][12]
static int _slist2[12];static double **_coef2;
static void seqinitial();
static int _slist1[12], _dlist1[12]; static double *_temp1;
static int activation();
static int activation ()
{_reset=0;
{
double b_flux, f_flux, _term; int _i;
{int _i; double _dt1 = 1.0/dt;
for(_i=1;_i<12;_i++){
_RHS1(_i) = -_dt1*(_p[_slist1[_i]] - _p[_dlist1[_i]]);
_MATELM1(_i, _i) = _dt1;
} }
rates ( _threadargscomma_ v ) ;
/* ~ C1 <-> C2 ( f01 , b01 )*/
f_flux = f01 * C1 ;
b_flux = b01 * C2 ;
_RHS1( 5) -= (f_flux - b_flux);
_RHS1( 4) += (f_flux - b_flux);
_term = f01 ;
_MATELM1( 5 ,5) += _term;
_MATELM1( 4 ,5) -= _term;
_term = b01 ;
_MATELM1( 5 ,4) -= _term;
_MATELM1( 4 ,4) += _term;
/*REACTION*/
/* ~ C2 <-> C3 ( f02 , b02 )*/
f_flux = f02 * C2 ;
b_flux = b02 * C3 ;
_RHS1( 4) -= (f_flux - b_flux);
_RHS1( 3) += (f_flux - b_flux);
_term = f02 ;
_MATELM1( 4 ,4) += _term;
_MATELM1( 3 ,4) -= _term;
_term = b02 ;
_MATELM1( 4 ,3) -= _term;
_MATELM1( 3 ,3) += _term;
/*REACTION*/
/* ~ C3 <-> C4 ( f03 , b03 )*/
f_flux = f03 * C3 ;
b_flux = b03 * C4 ;
_RHS1( 3) -= (f_flux - b_flux);
_RHS1( 2) += (f_flux - b_flux);
_term = f03 ;
_MATELM1( 3 ,3) += _term;
_MATELM1( 2 ,3) -= _term;
_term = b03 ;
_MATELM1( 3 ,2) -= _term;
_MATELM1( 2 ,2) += _term;
/*REACTION*/
/* ~ C4 <-> C5 ( f04 , b04 )*/
f_flux = f04 * C4 ;
b_flux = b04 * C5 ;
_RHS1( 2) -= (f_flux - b_flux);
_RHS1( 1) += (f_flux - b_flux);
_term = f04 ;
_MATELM1( 2 ,2) += _term;
_MATELM1( 1 ,2) -= _term;
_term = b04 ;
_MATELM1( 2 ,1) -= _term;
_MATELM1( 1 ,1) += _term;
/*REACTION*/
/* ~ C5 <-> O ( f0O , b0O )*/
f_flux = f0O * C5 ;
b_flux = b0O * O ;
_RHS1( 1) -= (f_flux - b_flux);
_RHS1( 11) += (f_flux - b_flux);
_term = f0O ;
_MATELM1( 1 ,1) += _term;
_MATELM1( 11 ,1) -= _term;
_term = b0O ;
_MATELM1( 1 ,11) -= _term;
_MATELM1( 11 ,11) += _term;
/*REACTION*/
/* ~ O <-> I6 ( fin , bin )*/
f_flux = fin * O ;
b_flux = bin * I6 ;
_RHS1( 11) -= (f_flux - b_flux);
_term = fin ;
_MATELM1( 11 ,11) += _term;
_term = bin ;
_MATELM1( 11 ,0) -= _term;
/*REACTION*/
/* ~ I1 <-> I2 ( f11 , b11 )*/
f_flux = f11 * I1 ;
b_flux = b11 * I2 ;
_RHS1( 10) -= (f_flux - b_flux);
_RHS1( 9) += (f_flux - b_flux);
_term = f11 ;
_MATELM1( 10 ,10) += _term;
_MATELM1( 9 ,10) -= _term;
_term = b11 ;
_MATELM1( 10 ,9) -= _term;
_MATELM1( 9 ,9) += _term;
/*REACTION*/
/* ~ I2 <-> I3 ( f12 , b12 )*/
f_flux = f12 * I2 ;
b_flux = b12 * I3 ;
_RHS1( 9) -= (f_flux - b_flux);
_RHS1( 8) += (f_flux - b_flux);
_term = f12 ;
_MATELM1( 9 ,9) += _term;
_MATELM1( 8 ,9) -= _term;
_term = b12 ;
_MATELM1( 9 ,8) -= _term;
_MATELM1( 8 ,8) += _term;
/*REACTION*/
/* ~ I3 <-> I4 ( f13 , b13 )*/
f_flux = f13 * I3 ;
b_flux = b13 * I4 ;
_RHS1( 8) -= (f_flux - b_flux);
_RHS1( 7) += (f_flux - b_flux);
_term = f13 ;
_MATELM1( 8 ,8) += _term;
_MATELM1( 7 ,8) -= _term;
_term = b13 ;
_MATELM1( 8 ,7) -= _term;
_MATELM1( 7 ,7) += _term;
/*REACTION*/
/* ~ I4 <-> I5 ( f14 , b14 )*/
f_flux = f14 * I4 ;
b_flux = b14 * I5 ;
_RHS1( 7) -= (f_flux - b_flux);
_RHS1( 6) += (f_flux - b_flux);
_term = f14 ;
_MATELM1( 7 ,7) += _term;
_MATELM1( 6 ,7) -= _term;
_term = b14 ;
_MATELM1( 7 ,6) -= _term;
_MATELM1( 6 ,6) += _term;
/*REACTION*/
/* ~ I5 <-> I6 ( f1n , b1n )*/
f_flux = f1n * I5 ;
b_flux = b1n * I6 ;
_RHS1( 6) -= (f_flux - b_flux);
_term = f1n ;
_MATELM1( 6 ,6) += _term;
_term = b1n ;
_MATELM1( 6 ,0) -= _term;
/*REACTION*/
/* ~ C1 <-> I1 ( fi1 , bi1 )*/
f_flux = fi1 * C1 ;
b_flux = bi1 * I1 ;
_RHS1( 5) -= (f_flux - b_flux);
_RHS1( 10) += (f_flux - b_flux);
_term = fi1 ;
_MATELM1( 5 ,5) += _term;
_MATELM1( 10 ,5) -= _term;
_term = bi1 ;
_MATELM1( 5 ,10) -= _term;
_MATELM1( 10 ,10) += _term;
/*REACTION*/
/* ~ C2 <-> I2 ( fi2 , bi2 )*/
f_flux = fi2 * C2 ;
b_flux = bi2 * I2 ;
_RHS1( 4) -= (f_flux - b_flux);
_RHS1( 9) += (f_flux - b_flux);
_term = fi2 ;
_MATELM1( 4 ,4) += _term;
_MATELM1( 9 ,4) -= _term;
_term = bi2 ;
_MATELM1( 4 ,9) -= _term;
_MATELM1( 9 ,9) += _term;
/*REACTION*/
/* ~ C3 <-> I3 ( fi3 , bi3 )*/
f_flux = fi3 * C3 ;
b_flux = bi3 * I3 ;
_RHS1( 3) -= (f_flux - b_flux);
_RHS1( 8) += (f_flux - b_flux);
_term = fi3 ;
_MATELM1( 3 ,3) += _term;
_MATELM1( 8 ,3) -= _term;
_term = bi3 ;
_MATELM1( 3 ,8) -= _term;
_MATELM1( 8 ,8) += _term;
/*REACTION*/
/* ~ C4 <-> I4 ( fi4 , bi4 )*/
f_flux = fi4 * C4 ;
b_flux = bi4 * I4 ;
_RHS1( 2) -= (f_flux - b_flux);
_RHS1( 7) += (f_flux - b_flux);
_term = fi4 ;
_MATELM1( 2 ,2) += _term;
_MATELM1( 7 ,2) -= _term;
_term = bi4 ;
_MATELM1( 2 ,7) -= _term;
_MATELM1( 7 ,7) += _term;
/*REACTION*/
/* ~ C5 <-> I5 ( fi5 , bi5 )*/
f_flux = fi5 * C5 ;
b_flux = bi5 * I5 ;
_RHS1( 1) -= (f_flux - b_flux);
_RHS1( 6) += (f_flux - b_flux);
_term = fi5 ;
_MATELM1( 1 ,1) += _term;
_MATELM1( 6 ,1) -= _term;
_term = bi5 ;
_MATELM1( 1 ,6) -= _term;
_MATELM1( 6 ,6) += _term;
/*REACTION*/
/* C1 + C2 + C3 + C4 + C5 + O + I1 + I2 + I3 + I4 + I5 + I6 = 1.0 */
_RHS1(0) = 1.0;
_MATELM1(0, 0) = 1;
_RHS1(0) -= I6 ;
_MATELM1(0, 6) = 1;
_RHS1(0) -= I5 ;
_MATELM1(0, 7) = 1;
_RHS1(0) -= I4 ;
_MATELM1(0, 8) = 1;
_RHS1(0) -= I3 ;
_MATELM1(0, 9) = 1;
_RHS1(0) -= I2 ;
_MATELM1(0, 10) = 1;
_RHS1(0) -= I1 ;
_MATELM1(0, 11) = 1;
_RHS1(0) -= O ;
_MATELM1(0, 1) = 1;
_RHS1(0) -= C5 ;
_MATELM1(0, 2) = 1;
_RHS1(0) -= C4 ;
_MATELM1(0, 3) = 1;
_RHS1(0) -= C3 ;
_MATELM1(0, 4) = 1;
_RHS1(0) -= C2 ;
_MATELM1(0, 5) = 1;
_RHS1(0) -= C1 ;
/*CONSERVATION*/
} return _reset;
}
static void seqinitial ()
{
zero_matrix(_coef2, 12, 13);
{
int _counte = -1;
++_counte;
_coef2[_counte][0] -= 1.0 * bi1 ;
_coef2[_counte][1] -= 1.0 * b01 ;
_coef2[_counte][2] += 1.0 * ( fi1 + f01 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][2] -= 1.0 * f01 ;
_coef2[_counte][3] -= 1.0 * bi2 ;
_coef2[_counte][4] -= 1.0 * b02 ;
_coef2[_counte][1] += 1.0 * ( b01 + fi2 + f02 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][1] -= 1.0 * f02 ;
_coef2[_counte][5] -= 1.0 * bi3 ;
_coef2[_counte][6] -= 1.0 * b03 ;
_coef2[_counte][4] += 1.0 * ( b02 + fi3 + f03 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][4] -= 1.0 * f03 ;
_coef2[_counte][7] -= 1.0 * bi4 ;
_coef2[_counte][8] -= 1.0 * b04 ;
_coef2[_counte][6] += 1.0 * ( b03 + fi4 + f04 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][6] -= 1.0 * f04 ;
_coef2[_counte][9] -= 1.0 * bi5 ;
_coef2[_counte][10] -= 1.0 * b0O ;
_coef2[_counte][8] += 1.0 * ( b04 + fi5 + f0O ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][8] -= 1.0 * f0O ;
_coef2[_counte][11] -= 1.0 * bin ;
_coef2[_counte][10] += 1.0 * ( b0O + fin ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][2] -= 1.0 * fi1 ;
_coef2[_counte][3] -= 1.0 * b11 ;
_coef2[_counte][0] += 1.0 * ( bi1 + f11 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][0] -= 1.0 * f11 ;
_coef2[_counte][1] -= 1.0 * fi2 ;
_coef2[_counte][5] -= 1.0 * b12 ;
_coef2[_counte][3] += 1.0 * ( b11 + bi2 + f12 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][3] -= 1.0 * f12 ;
_coef2[_counte][4] -= 1.0 * fi3 ;
_coef2[_counte][7] -= 1.0 * bi3 ;
_coef2[_counte][5] += 1.0 * ( b12 + bi3 + f13 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][5] -= 1.0 * f13 ;
_coef2[_counte][6] -= 1.0 * fi4 ;
_coef2[_counte][9] -= 1.0 * b14 ;
_coef2[_counte][7] += 1.0 * ( b13 + bi4 + f14 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][7] -= 1.0 * f14 ;
_coef2[_counte][8] -= 1.0 * fi5 ;
_coef2[_counte][11] -= 1.0 * b1n ;
_coef2[_counte][9] += 1.0 * ( b14 + bi5 + f1n ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][2] -= 1.0 ;
_coef2[_counte][1] -= 1.0 ;
_coef2[_counte][4] -= 1.0 ;
_coef2[_counte][6] -= 1.0 ;
_coef2[_counte][8] -= 1.0 ;
_coef2[_counte][10] -= 1.0 ;
_coef2[_counte][0] -= 1.0 ;
_coef2[_counte][3] -= 1.0 ;
_coef2[_counte][5] -= 1.0 ;
_coef2[_counte][7] -= 1.0 ;
_coef2[_counte][9] -= 1.0 ;
_coef2[_counte][11] -= 1.0 ;
_RHS2(_counte) -= 1.0 ;
;
}
}
static int rates ( double _lv ) {
double _lqt ;
_lqt = pow( 2.3 , ( ( celsius - 37.0 ) / 10.0 ) ) ;
f01 = _lqt * 4.0 * alpha * exp ( _lv / x1 ) ;
f02 = _lqt * 3.0 * alpha * exp ( _lv / x1 ) ;
f03 = _lqt * 2.0 * alpha * exp ( _lv / x1 ) ;
f04 = _lqt * 1.0 * alpha * exp ( _lv / x1 ) ;
f0O = _lqt * gamma ;
f11 = _lqt * 4.0 * alpha * alfac * exp ( _lv / x1 ) ;
f12 = _lqt * 3.0 * alpha * alfac * exp ( _lv / x1 ) ;
f13 = _lqt * 2.0 * alpha * alfac * exp ( _lv / x1 ) ;
f14 = _lqt * 1.0 * alpha * alfac * exp ( _lv / x1 ) ;
f1n = _lqt * gamma ;
fi1 = _lqt * Con ;
fi2 = _lqt * Con * alfac ;
fi3 = _lqt * Con * pow( alfac , 2.0 ) ;
fi4 = _lqt * Con * pow( alfac , 3.0 ) ;
fi5 = _lqt * Con * pow( alfac , 4.0 ) ;
fin = _lqt * Oon ;
b01 = _lqt * 1.0 * beta * exp ( _lv / x2 ) ;
b02 = _lqt * 2.0 * beta * exp ( _lv / x2 ) ;
b03 = _lqt * 3.0 * beta * exp ( _lv / x2 ) ;
b04 = _lqt * 4.0 * beta * exp ( _lv / x2 ) ;
b0O = _lqt * delta ;
b11 = _lqt * 1.0 * beta * exp ( _lv / x2 ) / btfac ;
b12 = _lqt * 2.0 * beta * exp ( _lv / x2 ) / btfac ;
b13 = _lqt * 3.0 * beta * exp ( _lv / x2 ) / btfac ;
b14 = _lqt * 4.0 * beta * exp ( _lv / x2 ) / btfac ;
b1n = _lqt * delta ;
bi1 = _lqt * Coff ;
bi2 = _lqt * Coff / ( btfac ) ;
bi3 = _lqt * Coff / ( pow( btfac , 2.0 ) ) ;
bi4 = _lqt * Coff / ( pow( btfac , 3.0 ) ) ;
bi5 = _lqt * Coff / ( pow( btfac , 4.0 ) ) ;
bin = _lqt * Ooff ;
return 0; }
static void _hoc_rates(void) {
double _r;
_r = 1.;
rates ( *getarg(1) );
hoc_retpushx(_r);
}
/*CVODE ode begin*/
static int _ode_spec1() {_reset=0;{
double b_flux, f_flux, _term; int _i;
{int _i; for(_i=0;_i<12;_i++) _p[_dlist1[_i]] = 0.0;}
rates ( _threadargscomma_ v ) ;
/* ~ C1 <-> C2 ( f01 , b01 )*/
f_flux = f01 * C1 ;
b_flux = b01 * C2 ;
DC1 -= (f_flux - b_flux);
DC2 += (f_flux - b_flux);
/*REACTION*/
/* ~ C2 <-> C3 ( f02 , b02 )*/
f_flux = f02 * C2 ;
b_flux = b02 * C3 ;
DC2 -= (f_flux - b_flux);
DC3 += (f_flux - b_flux);
/*REACTION*/
/* ~ C3 <-> C4 ( f03 , b03 )*/
f_flux = f03 * C3 ;
b_flux = b03 * C4 ;
DC3 -= (f_flux - b_flux);
DC4 += (f_flux - b_flux);
/*REACTION*/
/* ~ C4 <-> C5 ( f04 , b04 )*/
f_flux = f04 * C4 ;
b_flux = b04 * C5 ;
DC4 -= (f_flux - b_flux);
DC5 += (f_flux - b_flux);
/*REACTION*/
/* ~ C5 <-> O ( f0O , b0O )*/
f_flux = f0O * C5 ;
b_flux = b0O * O ;
DC5 -= (f_flux - b_flux);
DO += (f_flux - b_flux);
/*REACTION*/
/* ~ O <-> I6 ( fin , bin )*/
f_flux = fin * O ;
b_flux = bin * I6 ;
DO -= (f_flux - b_flux);
DI6 += (f_flux - b_flux);
/*REACTION*/
/* ~ I1 <-> I2 ( f11 , b11 )*/
f_flux = f11 * I1 ;
b_flux = b11 * I2 ;
DI1 -= (f_flux - b_flux);
DI2 += (f_flux - b_flux);
/*REACTION*/
/* ~ I2 <-> I3 ( f12 , b12 )*/
f_flux = f12 * I2 ;
b_flux = b12 * I3 ;
DI2 -= (f_flux - b_flux);
DI3 += (f_flux - b_flux);
/*REACTION*/
/* ~ I3 <-> I4 ( f13 , b13 )*/
f_flux = f13 * I3 ;
b_flux = b13 * I4 ;
DI3 -= (f_flux - b_flux);
DI4 += (f_flux - b_flux);
/*REACTION*/
/* ~ I4 <-> I5 ( f14 , b14 )*/
f_flux = f14 * I4 ;
b_flux = b14 * I5 ;
DI4 -= (f_flux - b_flux);
DI5 += (f_flux - b_flux);
/*REACTION*/
/* ~ I5 <-> I6 ( f1n , b1n )*/
f_flux = f1n * I5 ;
b_flux = b1n * I6 ;
DI5 -= (f_flux - b_flux);
DI6 += (f_flux - b_flux);
/*REACTION*/
/* ~ C1 <-> I1 ( fi1 , bi1 )*/
f_flux = fi1 * C1 ;
b_flux = bi1 * I1 ;
DC1 -= (f_flux - b_flux);
DI1 += (f_flux - b_flux);
/*REACTION*/
/* ~ C2 <-> I2 ( fi2 , bi2 )*/
f_flux = fi2 * C2 ;
b_flux = bi2 * I2 ;
DC2 -= (f_flux - b_flux);
DI2 += (f_flux - b_flux);
/*REACTION*/
/* ~ C3 <-> I3 ( fi3 , bi3 )*/
f_flux = fi3 * C3 ;
b_flux = bi3 * I3 ;
DC3 -= (f_flux - b_flux);
DI3 += (f_flux - b_flux);
/*REACTION*/
/* ~ C4 <-> I4 ( fi4 , bi4 )*/
f_flux = fi4 * C4 ;
b_flux = bi4 * I4 ;
DC4 -= (f_flux - b_flux);
DI4 += (f_flux - b_flux);
/*REACTION*/
/* ~ C5 <-> I5 ( fi5 , bi5 )*/
f_flux = fi5 * C5 ;
b_flux = bi5 * I5 ;
DC5 -= (f_flux - b_flux);
DI5 += (f_flux - b_flux);
/*REACTION*/
/* C1 + C2 + C3 + C4 + C5 + O + I1 + I2 + I3 + I4 + I5 + I6 = 1.0 */
/*CONSERVATION*/
} return _reset;
}
/*CVODE matsol*/
static int _ode_matsol1() {_reset=0;{
double b_flux, f_flux, _term; int _i;
b_flux = f_flux = 0.;
{int _i; double _dt1 = 1.0/dt;
for(_i=0;_i<12;_i++){
_RHS1(_i) = _dt1*(_p[_dlist1[_i]]);
_MATELM1(_i, _i) = _dt1;
} }
rates ( _threadargscomma_ v ) ;
/* ~ C1 <-> C2 ( f01 , b01 )*/
_term = f01 ;
_MATELM1( 5 ,5) += _term;
_MATELM1( 4 ,5) -= _term;
_term = b01 ;
_MATELM1( 5 ,4) -= _term;
_MATELM1( 4 ,4) += _term;
/*REACTION*/
/* ~ C2 <-> C3 ( f02 , b02 )*/
_term = f02 ;
_MATELM1( 4 ,4) += _term;
_MATELM1( 3 ,4) -= _term;
_term = b02 ;
_MATELM1( 4 ,3) -= _term;
_MATELM1( 3 ,3) += _term;
/*REACTION*/
/* ~ C3 <-> C4 ( f03 , b03 )*/
_term = f03 ;
_MATELM1( 3 ,3) += _term;
_MATELM1( 2 ,3) -= _term;
_term = b03 ;
_MATELM1( 3 ,2) -= _term;
_MATELM1( 2 ,2) += _term;
/*REACTION*/
/* ~ C4 <-> C5 ( f04 , b04 )*/
_term = f04 ;
_MATELM1( 2 ,2) += _term;
_MATELM1( 1 ,2) -= _term;
_term = b04 ;
_MATELM1( 2 ,1) -= _term;
_MATELM1( 1 ,1) += _term;
/*REACTION*/
/* ~ C5 <-> O ( f0O , b0O )*/
_term = f0O ;
_MATELM1( 1 ,1) += _term;
_MATELM1( 11 ,1) -= _term;
_term = b0O ;
_MATELM1( 1 ,11) -= _term;
_MATELM1( 11 ,11) += _term;
/*REACTION*/
/* ~ O <-> I6 ( fin , bin )*/
_term = fin ;
_MATELM1( 11 ,11) += _term;
_MATELM1( 0 ,11) -= _term;
_term = bin ;
_MATELM1( 11 ,0) -= _term;
_MATELM1( 0 ,0) += _term;
/*REACTION*/
/* ~ I1 <-> I2 ( f11 , b11 )*/
_term = f11 ;
_MATELM1( 10 ,10) += _term;
_MATELM1( 9 ,10) -= _term;
_term = b11 ;
_MATELM1( 10 ,9) -= _term;
_MATELM1( 9 ,9) += _term;
/*REACTION*/
/* ~ I2 <-> I3 ( f12 , b12 )*/
_term = f12 ;
_MATELM1( 9 ,9) += _term;
_MATELM1( 8 ,9) -= _term;
_term = b12 ;
_MATELM1( 9 ,8) -= _term;
_MATELM1( 8 ,8) += _term;
/*REACTION*/
/* ~ I3 <-> I4 ( f13 , b13 )*/
_term = f13 ;
_MATELM1( 8 ,8) += _term;
_MATELM1( 7 ,8) -= _term;
_term = b13 ;
_MATELM1( 8 ,7) -= _term;
_MATELM1( 7 ,7) += _term;
/*REACTION*/
/* ~ I4 <-> I5 ( f14 , b14 )*/
_term = f14 ;
_MATELM1( 7 ,7) += _term;
_MATELM1( 6 ,7) -= _term;
_term = b14 ;
_MATELM1( 7 ,6) -= _term;
_MATELM1( 6 ,6) += _term;
/*REACTION*/
/* ~ I5 <-> I6 ( f1n , b1n )*/
_term = f1n ;
_MATELM1( 6 ,6) += _term;
_MATELM1( 0 ,6) -= _term;
_term = b1n ;
_MATELM1( 6 ,0) -= _term;
_MATELM1( 0 ,0) += _term;
/*REACTION*/
/* ~ C1 <-> I1 ( fi1 , bi1 )*/
_term = fi1 ;
_MATELM1( 5 ,5) += _term;
_MATELM1( 10 ,5) -= _term;
_term = bi1 ;
_MATELM1( 5 ,10) -= _term;
_MATELM1( 10 ,10) += _term;
/*REACTION*/
/* ~ C2 <-> I2 ( fi2 , bi2 )*/
_term = fi2 ;
_MATELM1( 4 ,4) += _term;
_MATELM1( 9 ,4) -= _term;
_term = bi2 ;
_MATELM1( 4 ,9) -= _term;
_MATELM1( 9 ,9) += _term;
/*REACTION*/
/* ~ C3 <-> I3 ( fi3 , bi3 )*/
_term = fi3 ;
_MATELM1( 3 ,3) += _term;
_MATELM1( 8 ,3) -= _term;
_term = bi3 ;
_MATELM1( 3 ,8) -= _term;
_MATELM1( 8 ,8) += _term;
/*REACTION*/
/* ~ C4 <-> I4 ( fi4 , bi4 )*/
_term = fi4 ;
_MATELM1( 2 ,2) += _term;
_MATELM1( 7 ,2) -= _term;
_term = bi4 ;
_MATELM1( 2 ,7) -= _term;
_MATELM1( 7 ,7) += _term;
/*REACTION*/
/* ~ C5 <-> I5 ( fi5 , bi5 )*/
_term = fi5 ;
_MATELM1( 1 ,1) += _term;
_MATELM1( 6 ,1) -= _term;
_term = bi5 ;
_MATELM1( 1 ,6) -= _term;
_MATELM1( 6 ,6) += _term;
/*REACTION*/
/* C1 + C2 + C3 + C4 + C5 + O + I1 + I2 + I3 + I4 + I5 + I6 = 1.0 */
/*CONSERVATION*/
} return _reset;
}
/*CVODE end*/
static int _ode_count(int _type){ return 12;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ena = _ion_ena;
_ode_spec1 ();
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 12; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ena = _ion_ena;
_cvode_sparse(&_cvsparseobj1, 12, _dlist1, _p, _ode_matsol1, &_coef1);
}}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_na_sym, _ppvar, 0, 0);
nrn_update_ion_pointer(_na_sym, _ppvar, 1, 3);
nrn_update_ion_pointer(_na_sym, _ppvar, 2, 4);
}
static void initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
C5 = C50;
C4 = C40;
C3 = C30;
C2 = C20;
C1 = C10;
I6 = I60;
I5 = I50;
I4 = I40;
I3 = I30;
I2 = I20;
I1 = I10;
O = O0;
{
rates ( _threadargscomma_ v ) ;
error = 0; seqinitial();
error = simeq(12, _coef2, _p, _slist2);
if(error){fprintf(stderr,"at line 104 in file NaV.mod:\n SOLVE seqinitial\n"); nrn_complain(_p); abort_run(error);}
}
_sav_indep = t; t = _save;
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
ena = _ion_ena;
initmodel();
}}
static double _nrn_current(double _v){double _current=0.;v=_v;{ {
g = gbar * O ;
ina = g * ( v - ena ) ;
}
_current += ina;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
ena = _ion_ena;
_g = _nrn_current(_v + .001);
{ double _dina;
_dina = ina;
_rhs = _nrn_current(_v);
_ion_dinadv += (_dina - ina)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ina += ina ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
double _break, _save;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_break = t + .5*dt; _save = t;
v=_v;
{
ena = _ion_ena;
{ {
for (; t < _break; t += dt) {
error = sparse(&_sparseobj1, 12, _slist1, _dlist1, _p, &t, dt, activation,&_coef1, _linmat1);
if(error){fprintf(stderr,"at line 97 in file NaV.mod:\n SOLVE activation METHOD sparse\n"); nrn_complain(_p); abort_run(error);}
}}
t = _save;
} }}
}
static void terminal(){}
static void _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist2[0] = &(I1) - _p;
_slist2[1] = &(C2) - _p;
_slist2[2] = &(C1) - _p;
_slist2[3] = &(I2) - _p;
_slist2[4] = &(C3) - _p;
_slist2[5] = &(I3) - _p;
_slist2[6] = &(C4) - _p;
_slist2[7] = &(I4) - _p;
_slist2[8] = &(C5) - _p;
_slist2[9] = &(I5) - _p;
_slist2[10] = &(O) - _p;
_slist2[11] = &(I6) - _p;
if (_first) _coef2 = makematrix(12, 13);
_slist1[0] = &(I6) - _p; _dlist1[0] = &(DI6) - _p;
_slist1[1] = &(C5) - _p; _dlist1[1] = &(DC5) - _p;
_slist1[2] = &(C4) - _p; _dlist1[2] = &(DC4) - _p;
_slist1[3] = &(C3) - _p; _dlist1[3] = &(DC3) - _p;
_slist1[4] = &(C2) - _p; _dlist1[4] = &(DC2) - _p;
_slist1[5] = &(C1) - _p; _dlist1[5] = &(DC1) - _p;
_slist1[6] = &(I5) - _p; _dlist1[6] = &(DI5) - _p;
_slist1[7] = &(I4) - _p; _dlist1[7] = &(DI4) - _p;
_slist1[8] = &(I3) - _p; _dlist1[8] = &(DI3) - _p;
_slist1[9] = &(I2) - _p; _dlist1[9] = &(DI2) - _p;
_slist1[10] = &(I1) - _p; _dlist1[10] = &(DI1) - _p;
_slist1[11] = &(O) - _p; _dlist1[11] = &(DO) - _p;
_first = 0;
}