// protodefs.g - Definition of prototype elements for Auditory Cortex Cells /* Included files are in genesis/Scripts/neurokit/prototypes */ float EREST_ACT = -0.07 // resting membrane potential (volts) float ENA = 0.045 // sodium equilibrium potential float EK = -0.082 // potassium equilibrium potential /* file for standard compartments */ include compartments // include the definitions for the functions to create channels include pyrchans.g // Make a "library element" to hold the prototypes, which will be used // by the cell reader to add compartments and channels to the cell. if (!{exists /library}) // But, only if it doesn't already exist create neutral /library end // We don't want the library to try to calculate anything, so we disable it disable /library // To ensure that all subsequent elements are made in the library pushe /library /* Make a prototype compartment. The internal fields will be set by the cell reader, so they do not need to be set here. The make_cylind_compartment function is defined in compartments.g. */ make_cylind_compartment /* makes "symcompartment", if needed */ // make_cylind_symcompartment /* Make the pyramidal cell channels. Note that pyrchans.g changes some global variables. Different values could be added here. */ /* the values in pyrchans.g are float EREST_ACT = -0.060 // hippocampal cell resting potl float ENA = 0.115 + EREST_ACT // 0.055 float EK = -0.015 + EREST_ACT // -0.075 float ECA = 0.140 + EREST_ACT // 0.080 */ make_Na_hip_traub91 Na_pyr make_Kdr_hip_traub91 Kdr_pyr // slow down the firng by doubling Kdr_pyr scaletabchan Kdr_pyr X tau 1.0 2.0 0.0 0.0 make_Ca_hip_traub91 // This needs to keep the name Ca_hip_traub91 make_Kahp_hip_traub91 Kahp_pyr /* The original traub91 Kahp tau had a max of 1 sec at [Ca]=0, dropping to 0.2 when [Ca]=200, and 0.1 at higher values. This scaling makes the typical range 10-50 msec, which is roughly the time for adaptation in neocortical pyramidal cells. */ scaletabchan Kahp_pyr Z tau 1.0 0.05 0.0 0.0 make_Ca_hip_conc Ca_conc /* The original Ca_conc tau was 0.0133 sec. A value of 0.05 sec gives [Ca] more time to decay. */ setfield Ca_conc tau 0.1 /* Make the synaptically activated channels */ make_AMPA_pyr AMPA_pyr /* synchan with Ek = 0.0, tau1 = tau2 = 3 msec */ make_GABA_pyr GABA_pyr /* synchan with Ek = -0.080, tau1 = 3, tau2 = 8 msec */ /* make a spike generator */ create spikegen spike setfield spike thresh 0.00 abs_refract 1.0e-3 output_amp 1 /* Make the Fast Spiking basket cell channels. */ include FSchans.g /* Note that FSchans.g changes some global variables. Different values could be added here, before creating the channels. */ /* the values in baskchans.g are float EREST_ACT = -0.063 // value for vtraub in Destexhe et al. (2001) float ENA = 0.050 float EK = -0.090 */ make_Na_traub_mod Na_bask make_K_traub_mod Kdr_bask // speed them up by scaling the activation time constants by 0.5 scaletabchan Na_bask X tau 1.0 0.5 0.0 0.0 scaletabchan Na_bask Y tau 1.0 0.5 0.0 0.0 scaletabchan Kdr_bask X tau 1.0 0.5 0.0 0.0 /* Make the synaptically activated channels */ // Presently, AMPA_bask and GABA_bask are the same as AMPA_pyr and GABA_pyr make_AMPA_bask AMPA_bask // synchan with Ek = 0.0, tau1 = tau2 = 3 msec */ copy AMPA_bask AMPA_bask_drive // make a similar channel for Ex drive input make_GABA_bask GABA_bask // synchan with Ek = -0.080, tau1 = 3, tau2 = 8 msec pope // Return to the original place in the element tree