/*-------------------------------------------------------------- TEMPLATE FILE FOR LTS CORTICAL PYRAMIDAL CELL --------------------------------------------- One compartment model and currents derived from: Pospischil, M., Toledo-Rodriguez, M., Monier, C., Piwkowska, Z., Bal, T., Fregnac, Y., Markram, H. and Destexhe, A. Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons. Biological Cybernetics 99: 427-441, 2008. Model taken from: Destexhe, A. Contreras, D. and Steriade, M. LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations. Neurocomputing 38: 555-563 (2001). - one compartment model - passive - HH Traub - IM - T-type calcium current Alain Destexhe, CNRS, 2008 --------------------------------------------------------------*/ print " " print " << defining template for one-compartment sPYr cell >> " print " " begintemplate sPYr // create a new template object public soma create soma[1] proc init() { local v_potassium, v_sodium v_potassium = -100 // potassium reversal potential v_sodium = 50 // sodium reversal potential soma { Ra = 100 // geometry nseg = 1 diam = 96 L = 96 // so that area is about 29000 um2 cm = 1 insert pas // leak current e_pas = -70 g_pas = 1e-5 // idem TC cell // conversion with McC units: // g(S/cm2) = g(nS)*1e-9/29000e-8 // = g(nS) * 3.45e-6 insert hh2 // Hodgin-Huxley INa and IK ek = v_potassium ena = v_sodium vtraub_hh2 = -55 // Resting Vm, BJ was -55 gnabar_hh2 = 0.05 // McCormick=15 muS, thal was 0.09 gkbar_hh2 = 0.005 // spike duration of pyr cells insert im // M current taumax_im = 1000 gkbar_im = 3e-5 // specific to LTS pyr cell insert cad // calcium decay depth_cad = 1 // McCormick= 0.1 um taur_cad = 5 // McCormick=1 ms !!! cainf_cad = 2.4e-4 // McCormick=0 kt_cad = 0 // no pump insert it // IT current cai = 2.4e-4 cao = 2 eca = 120 gcabar_it = 0.001 // specific to LTS pyr cell } print " " print "<< sPYr: passive, INa, IK, Ca++, IT inserted >>" print " " } endtemplate sPYr