This is to replicate Fig.A3A in Alturki et al., 2016 AFTER YOU COMPILE THE FILES (see below): ORIGINAL To run the original model of Pospischil et al: 1- Click on mosinit.hoc, several windows will automatically pop up 2- Select IClamp from the "I/V Clamp Electrode" window 3- Select the cell type from the list in the "Simulations of cortical cells" window, we studied 4 cell types: - RS cell (the 1st one in the list) - Bursting (2nd in the list) - Low Threshold Spiking LTS (4th in the list) - FS (5th in the list) 4- After selecting the cell type, click on Init & Run fom the "RunControl" window SEGREGATED To run the segregated model of Pospischil et al: 1- Click on mosinit.hoc, several windows will automatically pop up 2- Select IClamp from the "I/V Clamp Electrode" window 3- Select the cell type from the list in the "Simulations of cortical cells" window.We studied 4 cell types: - RS cell (the 1st one in the list) - Bursting (2nd in the list) - Low Threshold Spiking LTS (4th in the list) - FS (5th in the list) 4- After selecting the cell type, click on Init & Run fom the "RunControl" window ____________________________________________________________________________ TO COMPILE AND RUN THE MODEL IN THE FOLDERS 'ORIGINAL' OR 'SEGREGATED' DO THE FOLLOWING: Under unix systems: to compile the mod files use the command nrnivmodl and run the simulation hoc file with the command nrngui FILENAME.hoc Under Windows systems: to compile the mod files use the "mknrndll" command. A double click on the simulation file FILENAME.hoc will open the simulation window. Under MAC OS X: Drag and drop the FILE folder onto the mknrndll icon in the NEURON application folder. When the mod files are finished compiling, double click on the simulation file FILENAME.hoc