This is to replicate Fig.5 in Alturki et al., 2016 ORIGINAL To run the original model of 1-comp LA model: 1- Click on main_LTO.hoc, to replicate all "original" curves in Fig.5A 2- Open main.hoc with any text editor, change cell type in Line 8 with one of the three: Cell_A(),Cell_B() and Cell_C(). Then close editor, and click on main.hoc, to replicate all "original" curves in Fig.5B with corresponding cell type. SEGREGATED To run the segregated model of 1-comp LA model: 1- Click on main_LTO.hoc, to replicate all "segregated" curves in Fig.5A 2- Open main.hoc with any text editor, change cell type in Line 8 with one of the three: Cell_A(),Cell_B() and Cell_C(). Then close editor, and click on main.hoc, to replicate all "original" curves in Fig.5B with corresponding cell type. 3- Click on main_HTO.hoc, to replicate all "segregated" curves in Fig.5C ____________________________________________________________________________ TO COMPILE AND RUN THE MODEL IN THE FOLDERS 'ORIGINAL' OR 'SEGREGATED' DO THE FOLLOWING: Under unix systems: to compile the mod files use the command nrnivmodl and run the simulation hoc file with the command nrngui FILENAME.hoc Under Windows systems: to compile the mod files use the "mknrndll" command. A double click on the simulation file FILENAME.hoc will open the simulation window. Under MAC OS X: Drag and drop the FILE folder onto the mknrndll icon in the NEURON application folder. When the mod files are finished compiling, double click on the simulation file FILENAME.hoc