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<b>Mass action rate law for first order irreversible reactions</b>
<p>
Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant.
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cAMP(200)
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</ListOfConstants>
<KineticLaw function="Function_13">
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</Reaction>
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</CallParameter>
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</ListOfSubstrates>
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</ListOfProducts>
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</ListOfConstants>
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</CallParameter>
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</CallParameter>
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</StateTemplate>
<InitialState type="initialState">
0 3.10758343605141 13.41104587391453 1.691703631506211 1.818386232467847e-006 3.024105913642569e-005 31.32909784743825 1.049090335191461e-007 0.03632335451922492 0.001269746328188461 0.06570297573634842 1.376735024935352e-005 0.003761193898454088 0.07840074607812511 0.0001035915625503994 0.0001040869025021617 0.0001040869021432897 0.000103591563368765 0.003382354279481966 0.002542196321834093 0.2756140383928879 0.1032783960941106 0.2753861548285351 0.1032783963426583 6.173180669861054e-005 8.719941743156724e-006 4.995101832381687e-008 8.013143653275379e-010 0.001267639802968621 1.132489765044846e-007 0.005369319209398891 8.267872498015523e-009 2.083408057118642e-007 0.00129234586493484 9.770621660142869e-008 0.0005668470112544343 3.741671038282527e-008 2.205959706176575e-008 3.009204103302597e-007 3.377933838900935e-008 5.319712939544274e-008 0.135342421541726 4.550336125374473e-005 0.001323439376125296 1.153129621044515e-009 0.005737288329174181 5.578609698663463e-009 0.0005749953208690789 1.073765055223353e-008 1.554627364361742e-007 1.964247284829825e-006 7.214028482776186e-007 1.202411080002878e-009 0.001857179092993393 1.869685947785706e-008 1.602914560684392e-009 0.0005868322587143332 9.467023973242569e-009 0.001265948057182333 0.01065533760643512 3.083848273173772e-010 0.1075360656946751 4.972080299615481e-010 0.02394959303787264 5.49416114561121e-009 5.86957295091335e-010 0.02452131585454392 6.449798038645588e-011 0.01050489009577348 2.22324032504178e-009 0.1002797512029424 17.04273383417815 1.305143267176992e-009 1.069556699830154e-006 0.0007226681586892123 1.804070344545309e-009 4.681122991249625e-008 0.002038464927087084 7.223456826056215e-007 9.854424097716515e-009 0.0008323503525569922 2.490866381767765e-009 0.001302680425578123 0.1586280210163954 2.430721304077339e-011 1.435892857470409e-007 1.911250573398954e-005 8.492941031902861e-007 0.0003611062479042943 1.019984947713562e-007 3.105646963874389e-005 1.929950013278314e-005 2.005422232549804e-007 3.724914085862591e-008 5.05272342084842e-005 2.263637026871941e-006 3.676515877943488e-005 1.977569633984133e-005 2.46032524855559e-006 0.0001502102380067975 0.0002623232092856433 0.0001604752792154366 1.031422689040799e-005 1.959453232350536e-005 6.038769619249948e-007 5.132936292169948e-005 5.590110264320661e-006 0.000891381892748554 0.000186160724459733 0.002644319033130063 1.991975028694079e-005 6.052807659584044e-008 0.07348997385834714 4.04584745446423e-011 0.005409920408182526 0.0004248448866448205 3.249566622874677e-010 0.2325061359466932 2.90054230674963e-005 0.0002744525665672407 0.0001549974068081452 5.578727117750794e-011 0.1584118319964099 3.433655864409598e-008 2.487372910594736e-006 6.00375883234454e-006 3.862139713272429e-008 0.01483194741694891 6.543903445264268e-008 1.450135042977629e-005 1.480559503485084e-005 5.345149122005669e-007 7.548923931276195e-009 0.0001472644160639088 1.796080270370923e-007 2.308640057781524e-006 0.0139403397446566 3.251618052607621e-008 0.0001014536248700419 1.414104756095607e-010 0.02412443382405617 6.016908102540898e-006 0.03803775160580171 5.511371015580114e-010 0.0004781693349539114 1.096130086156832e-005 0.0001985916961145168 0.01541322988712549 9.621215369921689e-011 0.00071327344420697 6.513016599286229e-005 0.0001018351642109905 0.004311656197118345 8.467269879583993e-006 5.242007038270652e-005 0.001627913120762332 1.343986059034551e-006 3.223627577590548e-005 6.265390230510537e-008 3.387741131007876e-005 0.000275088581848076 4.155143491992337e-005 7.470734987499817e-007 3.065782653775028e-007 0.0001273655375395768 4.953086497274066e-005 1.6387003778483e-005 8.083119664569086e-005 0.002474216266245643 1.710548211605934e-008 4.484352657608761e-005 0.78466521022234 6.110485454542114e-005 3.081951251447033e-005 8.753746554543028e-009 0.001042999996862808 6.391029255707242e-005 1.049017264729514 0.01984663952252257 1868.84772623949 275.1430018321562 1.560329768425037e-005 27.9515933422156 0 746.5381238422932 0.02976827258400815 4.230339072372422e-006 1.573481426188504 0.002055369953786461 6.173172399820368e-005 3.152196773494484e-006 0.001564366889056653 4.676889047147759 0 0.143909555495229 40000 13600 1.069906904248899 0.08832081494574663 0.005238307820026336 0.09355912276577297 1117.5890733882 0 2.062e-016 0.204 17 0.408 -65 0.1266 10.125 8.4 0.042 2.1483 0.0107
</InitialState>
</Model>
<ListOfTasks>
<Task key="Task_14" name="Steady-State" type="steadyState" scheduled="false" updateModel="false">
<Report reference="Report_9" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="JacobianRequested" type="bool" value="1"/>
<Parameter name="StabilityAnalysisRequested" type="bool" value="1"/>
</Problem>
<Method name="Enhanced Newton" type="EnhancedNewton">
<Parameter name="Resolution" type="unsignedFloat" value="1e-009"/>
<Parameter name="Derivation Factor" type="unsignedFloat" value="0.001"/>
<Parameter name="Use Newton" type="bool" value="1"/>
<Parameter name="Use Integration" type="bool" value="1"/>
<Parameter name="Use Back Integration" type="bool" value="1"/>
<Parameter name="Accept Negative Concentrations" type="bool" value="0"/>
<Parameter name="Iteration Limit" type="unsignedInteger" value="50"/>
<Parameter name="Maximum duration for forward integration" type="unsignedFloat" value="1000000000"/>
<Parameter name="Maximum duration for backward integration" type="unsignedFloat" value="1000000"/>
</Method>
</Task>
<Task key="Task_15" name="Time-Course" type="timeCourse" scheduled="false" updateModel="false">
<Report reference="Report_18" target="" append="0" confirmOverwrite="1"/>
<Problem>
<Parameter name="StepNumber" type="unsignedInteger" value="10000"/>
<Parameter name="StepSize" type="float" value="0.001"/>
<Parameter name="Duration" type="float" value="10"/>
<Parameter name="TimeSeriesRequested" type="bool" value="0"/>
<Parameter name="OutputStartTime" type="float" value="0"/>
<Parameter name="Output Event" type="bool" value="0"/>
</Problem>
<Method name="Stochastic (Direct method)" type="Stochastic">
<Parameter name="Max Internal Steps" type="integer" value="1000000"/>
<Parameter name="Use Random Seed" type="bool" value="0"/>
<Parameter name="Random Seed" type="unsignedInteger" value="1"/>
</Method>
</Task>
<Task key="Task_16" name="Scan" type="scan" scheduled="false" updateModel="false">
<Problem>
<Parameter name="Subtask" type="unsignedInteger" value="1"/>
<ParameterGroup name="ScanItems">
</ParameterGroup>
<Parameter name="Output in subtask" type="bool" value="1"/>
<Parameter name="Adjust initial conditions" type="bool" value="0"/>
</Problem>
<Method name="Scan Framework" type="ScanFramework">
</Method>
</Task>
<Task key="Task_17" name="Elementary Flux Modes" type="fluxMode" scheduled="false" updateModel="false">
<Report reference="Report_10" target="" append="1" confirmOverwrite="1"/>
<Problem>
</Problem>
<Method name="EFM Algorithm" type="EFMAlgorithm">
</Method>
</Task>
<Task key="Task_18" name="Optimization" type="optimization" scheduled="false" updateModel="false">
<Report reference="Report_11" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Subtask" type="cn" value="CN=Root,Vector=TaskList[Steady-State]"/>
<ParameterText name="ObjectiveExpression" type="expression">
</ParameterText>
<Parameter name="Maximize" type="bool" value="0"/>
<Parameter name="Randomize Start Values" type="bool" value="0"/>
<Parameter name="Calculate Statistics" type="bool" value="1"/>
<ParameterGroup name="OptimizationItemList">
</ParameterGroup>
<ParameterGroup name="OptimizationConstraintList">
</ParameterGroup>
</Problem>
<Method name="Random Search" type="RandomSearch">
<Parameter name="Number of Iterations" type="unsignedInteger" value="100000"/>
<Parameter name="Random Number Generator" type="unsignedInteger" value="1"/>
<Parameter name="Seed" type="unsignedInteger" value="0"/>
</Method>
</Task>
<Task key="Task_19" name="Parameter Estimation" type="parameterFitting" scheduled="false" updateModel="false">
<Report reference="Report_12" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Maximize" type="bool" value="0"/>
<Parameter name="Randomize Start Values" type="bool" value="0"/>
<Parameter name="Calculate Statistics" type="bool" value="1"/>
<ParameterGroup name="OptimizationItemList">
</ParameterGroup>
<ParameterGroup name="OptimizationConstraintList">
</ParameterGroup>
<Parameter name="Steady-State" type="cn" value="CN=Root,Vector=TaskList[Steady-State]"/>
<Parameter name="Time-Course" type="cn" value="CN=Root,Vector=TaskList[Time-Course]"/>
<ParameterGroup name="Experiment Set">
</ParameterGroup>
<ParameterGroup name="Validation Set">
<Parameter name="Threshold" type="unsignedInteger" value="5"/>
<Parameter name="Weight" type="unsignedFloat" value="1"/>
</ParameterGroup>
</Problem>
<Method name="Evolutionary Programming" type="EvolutionaryProgram">
<Parameter name="Number of Generations" type="unsignedInteger" value="200"/>
<Parameter name="Population Size" type="unsignedInteger" value="20"/>
<Parameter name="Random Number Generator" type="unsignedInteger" value="1"/>
<Parameter name="Seed" type="unsignedInteger" value="0"/>
</Method>
</Task>
<Task key="Task_20" name="Metabolic Control Analysis" type="metabolicControlAnalysis" scheduled="false" updateModel="false">
<Report reference="Report_13" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Steady-State" type="key" value="Task_14"/>
</Problem>
<Method name="MCA Method (Reder)" type="MCAMethod(Reder)">
<Parameter name="Modulation Factor" type="unsignedFloat" value="1e-009"/>
</Method>
</Task>
<Task key="Task_21" name="Lyapunov Exponents" type="lyapunovExponents" scheduled="false" updateModel="false">
<Report reference="Report_14" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="ExponentNumber" type="unsignedInteger" value="3"/>
<Parameter name="DivergenceRequested" type="bool" value="1"/>
<Parameter name="TransientTime" type="float" value="0"/>
</Problem>
<Method name="Wolf Method" type="WolfMethod">
<Parameter name="Orthonormalization Interval" type="unsignedFloat" value="1"/>
<Parameter name="Overall time" type="unsignedFloat" value="1000"/>
<Parameter name="Relative Tolerance" type="unsignedFloat" value="1e-006"/>
<Parameter name="Absolute Tolerance" type="unsignedFloat" value="1e-012"/>
<Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
</Method>
</Task>
<Task key="Task_22" name="Time Scale Separation Analysis" type="timeScaleSeparationAnalysis" scheduled="false" updateModel="false">
<Report reference="Report_15" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="StepNumber" type="unsignedInteger" value="100"/>
<Parameter name="StepSize" type="float" value="0.01"/>
<Parameter name="Duration" type="float" value="1"/>
<Parameter name="TimeSeriesRequested" type="bool" value="1"/>
<Parameter name="OutputStartTime" type="float" value="0"/>
</Problem>
<Method name="ILDM (LSODA,Deuflhard)" type="TimeScaleSeparation(ILDM,Deuflhard)">
<Parameter name="Deuflhard Tolerance" type="unsignedFloat" value="1e-006"/>
</Method>
</Task>
<Task key="Task_23" name="Sensitivities" type="sensitivities" scheduled="false" updateModel="false">
<Report reference="Report_16" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="SubtaskType" type="unsignedInteger" value="1"/>
<ParameterGroup name="TargetFunctions">
<Parameter name="SingleObject" type="cn" value=""/>
<Parameter name="ObjectListType" type="unsignedInteger" value="7"/>
</ParameterGroup>
<ParameterGroup name="ListOfVariables">
<ParameterGroup name="Variables">
<Parameter name="SingleObject" type="cn" value=""/>
<Parameter name="ObjectListType" type="unsignedInteger" value="41"/>
</ParameterGroup>
</ParameterGroup>
</Problem>
<Method name="Sensitivities Method" type="SensitivitiesMethod">
<Parameter name="Delta factor" type="unsignedFloat" value="0.001"/>
<Parameter name="Delta minimum" type="unsignedFloat" value="1e-012"/>
</Method>
</Task>
<Task key="Task_24" name="Moieties" type="moieties" scheduled="false" updateModel="false">
<Problem>
</Problem>
<Method name="Householder Reduction" type="Householder">
</Method>
</Task>
<Task key="Task_25" name="Cross Section" type="crosssection" scheduled="false" updateModel="false">
<Problem>
<Parameter name="StepNumber" type="unsignedInteger" value="100"/>
<Parameter name="StepSize" type="float" value="0.01"/>
<Parameter name="Duration" type="float" value="1"/>
<Parameter name="TimeSeriesRequested" type="bool" value="1"/>
<Parameter name="OutputStartTime" type="float" value="0"/>
<Parameter name="Output Event" type="bool" value="0"/>
<Parameter name="LimitCrossings" type="bool" value="0"/>
<Parameter name="NumCrossingsLimit" type="unsignedInteger" value="0"/>
<Parameter name="LimitOutTime" type="bool" value="0"/>
<Parameter name="LimitOutCrossings" type="bool" value="0"/>
<Parameter name="PositiveDirection" type="bool" value="1"/>
<Parameter name="NumOutCrossingsLimit" type="unsignedInteger" value="0"/>
<Parameter name="LimitUntilConvergence" type="bool" value="0"/>
<Parameter name="ConvergenceTolerance" type="float" value="1e-006"/>
<Parameter name="Threshold" type="float" value="0"/>
<Parameter name="DelayOutputUntilConvergence" type="bool" value="0"/>
<Parameter name="OutputConvergenceTolerance" type="float" value="1e-006"/>
<ParameterText name="TriggerExpression" type="expression">
</ParameterText>
<Parameter name="SingleVariable" type="cn" value=""/>
</Problem>
<Method name="Deterministic (LSODA)" type="Deterministic(LSODA)">
<Parameter name="Integrate Reduced Model" type="bool" value="0"/>
<Parameter name="Relative Tolerance" type="unsignedFloat" value="1e-006"/>
<Parameter name="Absolute Tolerance" type="unsignedFloat" value="1e-012"/>
<Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
</Method>
</Task>
<Task key="Task_26" name="Linear Noise Approximation" type="linearNoiseApproximation" scheduled="false" updateModel="false">
<Report reference="Report_17" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Steady-State" type="key" value="Task_14"/>
</Problem>
<Method name="Linear Noise Approximation" type="LinearNoiseApproximation">
</Method>
</Task>
</ListOfTasks>
<ListOfReports>
<Report key="Report_9" name="Steady-State" taskType="steadyState" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Footer>
<Object cn="CN=Root,Vector=TaskList[Steady-State]"/>
</Footer>
</Report>
<Report key="Report_10" name="Elementary Flux Modes" taskType="fluxMode" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Footer>
<Object cn="CN=Root,Vector=TaskList[Elementary Flux Modes],Object=Result"/>
</Footer>
</Report>
<Report key="Report_11" name="Optimization" taskType="optimization" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Optimization],Object=Description"/>
<Object cn="String=\[Function Evaluations\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Value\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Parameters\]"/>
</Header>
<Body>
<Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Function Evaluations"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Best Value"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Best Parameters"/>
</Body>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Optimization],Object=Result"/>
</Footer>
</Report>
<Report key="Report_12" name="Parameter Estimation" taskType="parameterFitting" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Object=Description"/>
<Object cn="String=\[Function Evaluations\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Value\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Parameters\]"/>
</Header>
<Body>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Function Evaluations"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Best Value"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Best Parameters"/>
</Body>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Object=Result"/>
</Footer>
</Report>
<Report key="Report_13" name="Metabolic Control Analysis" taskType="metabolicControlAnalysis" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Metabolic Control Analysis],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Metabolic Control Analysis],Object=Result"/>
</Footer>
</Report>
<Report key="Report_14" name="Lyapunov Exponents" taskType="lyapunovExponents" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Lyapunov Exponents],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Lyapunov Exponents],Object=Result"/>
</Footer>
</Report>
<Report key="Report_15" name="Time Scale Separation Analysis" taskType="timeScaleSeparationAnalysis" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Time Scale Separation Analysis],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Time Scale Separation Analysis],Object=Result"/>
</Footer>
</Report>
<Report key="Report_16" name="Sensitivities" taskType="sensitivities" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Sensitivities],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Sensitivities],Object=Result"/>
</Footer>
</Report>
<Report key="Report_17" name="Linear Noise Approximation" taskType="linearNoiseApproximation" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Linear Noise Approximation],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Linear Noise Approximation],Object=Result"/>
</Footer>
</Report>
<Report key="Report_18" name="Complete Time, Particle Numbers, Volumes, and Global Quantity Values" taskType="timeCourse" separator="	" precision="6">
<Comment>
A table of time, all species particle numbers, all compartment volumes, and all global quantity values (includes fixed ones).
</Comment>
<Table printTitle="1">
<Object cn="CN=Root,Model=Adaptacao,Reference=Time"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_III],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_III_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaM],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[Ca_NCX],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[NCX],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[PMCA],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_PMCA],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_PMCA_Ca],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_PMCA],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_PMCA_Ca],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_PMCA],Reference=ParticleNumber"/>
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<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP1_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP1_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP1_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP2_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP3_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP2_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP3_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP2_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP3_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP1_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP2_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP3_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[A],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[B],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CACopen_tot],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[Ca],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[Ca_bulk],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Reference=Volume"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_adap2],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_adap1],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_cam],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kf_cam],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_cam2],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[ICAC],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[ICNG],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[ICNGICAC],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[Vm1],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_cac],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_I_II_CNG_Ca_coop],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_I_II_CNG_Ca],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_III_CNG_Ca],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_III_CNG_Ca_coop],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_IV_CNG_Ca],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_IV_CNG_Ca_coop],Reference=Value"/>
</Table>
</Report>
</ListOfReports>
<ListOfPlots>
<PlotSpecification name="Ca2+" type="Plot2D" active="1">
<Parameter name="log X" type="bool" value="0"/>
<Parameter name="log Y" type="bool" value="0"/>
<ListOfPlotItems>
<PlotItem name="Ca.ParticleNumber|Time" type="Curve2D">
<Parameter name="Color" type="string" value="auto"/>
<Parameter name="Line subtype" type="unsignedInteger" value="0"/>
<Parameter name="Line type" type="unsignedInteger" value="0"/>
<Parameter name="Line width" type="unsignedFloat" value="1"/>
<Parameter name="Recording Activity" type="string" value="during"/>
<Parameter name="Symbol subtype" type="unsignedInteger" value="0"/>
<ListOfChannels>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Reference=Time"/>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[Ca],Reference=ParticleNumber"/>
</ListOfChannels>
</PlotItem>
</ListOfPlotItems>
</PlotSpecification>
<PlotSpecification name="ICNG" type="Plot2D" active="1">
<Parameter name="log X" type="bool" value="0"/>
<Parameter name="log Y" type="bool" value="0"/>
<ListOfPlotItems>
<PlotItem name="Values[ICNG]|Time" type="Curve2D">
<Parameter name="Color" type="string" value="auto"/>
<Parameter name="Line subtype" type="unsignedInteger" value="0"/>
<Parameter name="Line type" type="unsignedInteger" value="0"/>
<Parameter name="Line width" type="unsignedFloat" value="1"/>
<Parameter name="Recording Activity" type="string" value="during"/>
<Parameter name="Symbol subtype" type="unsignedInteger" value="0"/>
<ListOfChannels>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Reference=Time"/>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Vector=Values[ICNG],Reference=Value"/>
</ListOfChannels>
</PlotItem>
</ListOfPlotItems>
</PlotSpecification>
<PlotSpecification name="ICAC" type="Plot2D" active="1">
<Parameter name="log X" type="bool" value="0"/>
<Parameter name="log Y" type="bool" value="0"/>
<ListOfPlotItems>
<PlotItem name="Values[ICAC]|Time" type="Curve2D">
<Parameter name="Color" type="string" value="auto"/>
<Parameter name="Line subtype" type="unsignedInteger" value="0"/>
<Parameter name="Line type" type="unsignedInteger" value="0"/>
<Parameter name="Line width" type="unsignedFloat" value="1"/>
<Parameter name="Recording Activity" type="string" value="during"/>
<Parameter name="Symbol subtype" type="unsignedInteger" value="0"/>
<ListOfChannels>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Reference=Time"/>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Vector=Values[ICAC],Reference=Value"/>
</ListOfChannels>
</PlotItem>
</ListOfPlotItems>
</PlotSpecification>
</ListOfPlots>
<GUI>
</GUI>
</COPASI>