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<b>Mass action rate law for first order irreversible reactions</b>
<p>
Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant.
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</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_1230" name="a554" reversible="false">
<MiriamAnnotation>
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</rdf:Description>
</rdf:RDF>
</MiriamAnnotation>
<ListOfSubstrates>
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</ListOfSubstrates>
<ListOfProducts>
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</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_2667" name="k1" value="156.25"/>
</ListOfConstants>
<KineticLaw function="Function_13">
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<CallParameter functionParameter="FunctionParameter_81">
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</CallParameter>
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</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_1231" name="a555" reversible="false">
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</rdf:Description>
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</rdf:Description>
</rdf:RDF>
</MiriamAnnotation>
<ListOfSubstrates>
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</ListOfSubstrates>
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</ListOfProducts>
<ListOfConstants>
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</ListOfConstants>
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</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
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</KineticLaw>
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</KineticLaw>
</Reaction>
<Reaction key="Reaction_1234" name="a558" reversible="false">
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</MiriamAnnotation>
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<ListOfProducts>
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<ListOfConstants>
<Constant key="Parameter_2663" name="k1" value="156.25"/>
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<KineticLaw function="Function_13">
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<CallParameter functionParameter="FunctionParameter_81">
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</CallParameter>
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</KineticLaw>
</Reaction>
<Reaction key="Reaction_1235" name="a559" reversible="false">
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</MiriamAnnotation>
<ListOfSubstrates>
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<ListOfProducts>
<Product metabolite="Metabolite_193" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_2662" name="k1" value="750"/>
</ListOfConstants>
<KineticLaw function="Function_13">
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<CallParameter functionParameter="FunctionParameter_81">
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</CallParameter>
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</KineticLaw>
</Reaction>
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</MiriamAnnotation>
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</ListOfProducts>
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<KineticLaw function="Function_13">
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</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_1238" name="influxo" reversible="false">
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</MiriamAnnotation>
<ListOfSubstrates>
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<KineticLaw function="Function_13">
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</KineticLaw>
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</KineticLaw>
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</StateTemplate>
<InitialState type="initialState">
0 2.675301800639937 11.17589059043472 1.570973181656626 1.127821360895863e-006 2.476299074293927e-005 34.91141361210179 5.085759360981209e-008 0.03010968659763199 0.0006584729433375928 0.06111723384864592 5.086521311241489e-006 0.004189683056873255 0.0546055924353888 6.65600922723325e-005 6.695022853304876e-005 6.695022828617755e-005 6.656009278577607e-005 0.002231164617771808 0.002037439379019117 0.2055630106206976 0.0770132344392149 0.2053559858477357 0.07701323457820378 4.362665947464668e-005 6.449297369508836e-006 4.143732940859585e-008 4.70729710259514e-010 0.0009857463858105088 9.504843484878795e-008 0.004731976734304469 5.200364390796347e-009 1.869791600541583e-007 0.001016809319691935 6.776317879762513e-008 0.0004526278296535058 2.336706582230717e-008 1.828424166612182e-008 2.315536525541656e-007 2.666481129192772e-008 2.753737984631776e-008 0.09056967361376547 3.606413375223459e-005 0.00103550313607329 7.44691586818564e-010 0.005062923430934951 3.743760070708253e-009 0.0004581406794723286 7.670514149887149e-009 1.21967198545922e-007 1.685147305378243e-006 5.579801789281581e-007 7.087438038975229e-010 0.001414971144703401 1.539616103133331e-008 1.005739889854304e-009 0.0004672949242467765 5.517759460454418e-009 0.0009847018125938114 0.01018789568852841 1.694719610938417e-010 0.1137278405609477 2.554973698916719e-010 0.02261084630194394 3.11810033682188e-009 3.386240017776507e-010 0.0230231350214436 3.360459569687702e-011 0.01006556713742969 1.138025317552171e-009 0.1059404203669559 13.68573001131976 4.533529460006831e-010 7.566052321610681e-007 0.0006234945551974132 1.289312469279458e-009 3.954198171332561e-008 0.001701284969508949 4.405245033657386e-007 7.109191895314964e-009 0.0007011135544428641 1.634531934722747e-009 0.001071705259269519 0.1480556050641628 1.077053475912486e-011 7.247668747389601e-008 1.780040991086154e-005 4.013934002306244e-007 0.0003912365582970065 4.628197112885929e-008 2.834549565182109e-005 1.405750301322771e-005 1.802345054351434e-007 3.384129475536405e-008 3.946087785188886e-005 1.399894444106055e-006 2.396691021550946e-005 1.565985395014999e-005 1.426072492723067e-006 0.0001343990600195493 0.0002176727262480589 0.0001406123614656746 6.361979802333828e-006 1.55096478313522e-005 3.209401927518164e-007 4.006839220402416e-005 3.495919985160258e-006 0.0007086064625371657 0.0001514044312136742 0.002297574733360939 1.854287502694275e-005 2.564226774429744e-008 0.07025501136093772 1.872212916692135e-011 0.003620918089695508 0.0002160971813598394 1.545739574501512e-010 0.2126169195491588 2.441355293190643e-005 0.0002496715055322887 0.0001310269316151042 2.830862142766205e-011 0.1478944349729825 1.738662158563599e-008 2.441906733888912e-006 5.916019750514229e-006 2.034291580926072e-008 0.01060633841352184 3.216246088628391e-008 1.524454907460277e-005 1.561838740509696e-005 2.926812338700163e-007 3.396096792535501e-009 0.0001573121173325906 9.416127205224441e-008 2.258126007380567e-006 0.01434061585662618 1.660053647425084e-008 7.987739339205437e-005 7.448584543719872e-011 0.02381646786346696 3.425008375023951e-006 0.03809822739051457 3.249901967607144e-010 0.0003793044180419934 6.716013182355671e-006 0.0001381063478644692 0.01557955317081772 5.701495242942298e-011 0.0005937076409704849 3.695181118914385e-005 7.975233406879195e-005 0.00332612565523452 4.870923034492287e-006 3.951641094586897e-005 0.001374663044781535 7.286466014798268e-007 2.714245925013112e-005 3.407308458466529e-008 4.006185593668746e-005 0.0002488877437085521 3.353858925878974e-005 4.217840194006621e-007 1.766098645873192e-007 0.0001498814536431376 4.564943000544828e-005 1.118827098443148e-005 6.736823817681434e-005 0.001834936286467245 7.678955988189793e-009 5.089456592615104e-005 0.6759542449503818 5.245408953779363e-005 2.591328124710603e-005 5.075685416090983e-009 0.0006659215666889069 7.650213001694852e-005 0.9036821456377217 0.01471874026519677 1869.496908048697 238.3230255112552 9.962186638258888e-006 24.07771544090474 0 747.0245336820383 0.0220781103322622 2.678481863947978e-006 1.355523216448986 0.001649637995243149 4.36265977747393e-005 9.732933949777048e-007 0.0009988822758200439 4.027707237942536 0 0.123929454023876 40000 13600 0.9190668074696073 0.07586896495661608 0.004511032126469087 0.08037999708308516 1117.5890733882 0 2.062e-016 0.204 17 0.408 -65 0.1266 10.125 8.4 0.042 2.1483 0.0107
</InitialState>
</Model>
<ListOfTasks>
<Task key="Task_14" name="Steady-State" type="steadyState" scheduled="false" updateModel="false">
<Report reference="Report_9" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="JacobianRequested" type="bool" value="1"/>
<Parameter name="StabilityAnalysisRequested" type="bool" value="1"/>
</Problem>
<Method name="Enhanced Newton" type="EnhancedNewton">
<Parameter name="Resolution" type="unsignedFloat" value="1e-009"/>
<Parameter name="Derivation Factor" type="unsignedFloat" value="0.001"/>
<Parameter name="Use Newton" type="bool" value="1"/>
<Parameter name="Use Integration" type="bool" value="1"/>
<Parameter name="Use Back Integration" type="bool" value="1"/>
<Parameter name="Accept Negative Concentrations" type="bool" value="0"/>
<Parameter name="Iteration Limit" type="unsignedInteger" value="50"/>
<Parameter name="Maximum duration for forward integration" type="unsignedFloat" value="1000000000"/>
<Parameter name="Maximum duration for backward integration" type="unsignedFloat" value="1000000"/>
</Method>
</Task>
<Task key="Task_15" name="Time-Course" type="timeCourse" scheduled="false" updateModel="false">
<Report reference="Report_18" target="" append="0" confirmOverwrite="1"/>
<Problem>
<Parameter name="StepNumber" type="unsignedInteger" value="10000"/>
<Parameter name="StepSize" type="float" value="0.001"/>
<Parameter name="Duration" type="float" value="10"/>
<Parameter name="TimeSeriesRequested" type="bool" value="0"/>
<Parameter name="OutputStartTime" type="float" value="0"/>
<Parameter name="Output Event" type="bool" value="0"/>
</Problem>
<Method name="Stochastic (Direct method)" type="Stochastic">
<Parameter name="Max Internal Steps" type="integer" value="1000000"/>
<Parameter name="Use Random Seed" type="bool" value="0"/>
<Parameter name="Random Seed" type="unsignedInteger" value="1"/>
</Method>
</Task>
<Task key="Task_16" name="Scan" type="scan" scheduled="false" updateModel="false">
<Problem>
<Parameter name="Subtask" type="unsignedInteger" value="1"/>
<ParameterGroup name="ScanItems">
</ParameterGroup>
<Parameter name="Output in subtask" type="bool" value="1"/>
<Parameter name="Adjust initial conditions" type="bool" value="0"/>
</Problem>
<Method name="Scan Framework" type="ScanFramework">
</Method>
</Task>
<Task key="Task_17" name="Elementary Flux Modes" type="fluxMode" scheduled="false" updateModel="false">
<Report reference="Report_10" target="" append="1" confirmOverwrite="1"/>
<Problem>
</Problem>
<Method name="EFM Algorithm" type="EFMAlgorithm">
</Method>
</Task>
<Task key="Task_18" name="Optimization" type="optimization" scheduled="false" updateModel="false">
<Report reference="Report_11" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Subtask" type="cn" value="CN=Root,Vector=TaskList[Steady-State]"/>
<ParameterText name="ObjectiveExpression" type="expression">
</ParameterText>
<Parameter name="Maximize" type="bool" value="0"/>
<Parameter name="Randomize Start Values" type="bool" value="0"/>
<Parameter name="Calculate Statistics" type="bool" value="1"/>
<ParameterGroup name="OptimizationItemList">
</ParameterGroup>
<ParameterGroup name="OptimizationConstraintList">
</ParameterGroup>
</Problem>
<Method name="Random Search" type="RandomSearch">
<Parameter name="Number of Iterations" type="unsignedInteger" value="100000"/>
<Parameter name="Random Number Generator" type="unsignedInteger" value="1"/>
<Parameter name="Seed" type="unsignedInteger" value="0"/>
</Method>
</Task>
<Task key="Task_19" name="Parameter Estimation" type="parameterFitting" scheduled="false" updateModel="false">
<Report reference="Report_12" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Maximize" type="bool" value="0"/>
<Parameter name="Randomize Start Values" type="bool" value="0"/>
<Parameter name="Calculate Statistics" type="bool" value="1"/>
<ParameterGroup name="OptimizationItemList">
</ParameterGroup>
<ParameterGroup name="OptimizationConstraintList">
</ParameterGroup>
<Parameter name="Steady-State" type="cn" value="CN=Root,Vector=TaskList[Steady-State]"/>
<Parameter name="Time-Course" type="cn" value="CN=Root,Vector=TaskList[Time-Course]"/>
<ParameterGroup name="Experiment Set">
</ParameterGroup>
<ParameterGroup name="Validation Set">
<Parameter name="Threshold" type="unsignedInteger" value="5"/>
<Parameter name="Weight" type="unsignedFloat" value="1"/>
</ParameterGroup>
</Problem>
<Method name="Evolutionary Programming" type="EvolutionaryProgram">
<Parameter name="Number of Generations" type="unsignedInteger" value="200"/>
<Parameter name="Population Size" type="unsignedInteger" value="20"/>
<Parameter name="Random Number Generator" type="unsignedInteger" value="1"/>
<Parameter name="Seed" type="unsignedInteger" value="0"/>
</Method>
</Task>
<Task key="Task_20" name="Metabolic Control Analysis" type="metabolicControlAnalysis" scheduled="false" updateModel="false">
<Report reference="Report_13" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Steady-State" type="key" value="Task_14"/>
</Problem>
<Method name="MCA Method (Reder)" type="MCAMethod(Reder)">
<Parameter name="Modulation Factor" type="unsignedFloat" value="1e-009"/>
</Method>
</Task>
<Task key="Task_21" name="Lyapunov Exponents" type="lyapunovExponents" scheduled="false" updateModel="false">
<Report reference="Report_14" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="ExponentNumber" type="unsignedInteger" value="3"/>
<Parameter name="DivergenceRequested" type="bool" value="1"/>
<Parameter name="TransientTime" type="float" value="0"/>
</Problem>
<Method name="Wolf Method" type="WolfMethod">
<Parameter name="Orthonormalization Interval" type="unsignedFloat" value="1"/>
<Parameter name="Overall time" type="unsignedFloat" value="1000"/>
<Parameter name="Relative Tolerance" type="unsignedFloat" value="1e-006"/>
<Parameter name="Absolute Tolerance" type="unsignedFloat" value="1e-012"/>
<Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
</Method>
</Task>
<Task key="Task_22" name="Time Scale Separation Analysis" type="timeScaleSeparationAnalysis" scheduled="false" updateModel="false">
<Report reference="Report_15" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="StepNumber" type="unsignedInteger" value="100"/>
<Parameter name="StepSize" type="float" value="0.01"/>
<Parameter name="Duration" type="float" value="1"/>
<Parameter name="TimeSeriesRequested" type="bool" value="1"/>
<Parameter name="OutputStartTime" type="float" value="0"/>
</Problem>
<Method name="ILDM (LSODA,Deuflhard)" type="TimeScaleSeparation(ILDM,Deuflhard)">
<Parameter name="Deuflhard Tolerance" type="unsignedFloat" value="1e-006"/>
</Method>
</Task>
<Task key="Task_23" name="Sensitivities" type="sensitivities" scheduled="false" updateModel="false">
<Report reference="Report_16" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="SubtaskType" type="unsignedInteger" value="1"/>
<ParameterGroup name="TargetFunctions">
<Parameter name="SingleObject" type="cn" value=""/>
<Parameter name="ObjectListType" type="unsignedInteger" value="7"/>
</ParameterGroup>
<ParameterGroup name="ListOfVariables">
<ParameterGroup name="Variables">
<Parameter name="SingleObject" type="cn" value=""/>
<Parameter name="ObjectListType" type="unsignedInteger" value="41"/>
</ParameterGroup>
</ParameterGroup>
</Problem>
<Method name="Sensitivities Method" type="SensitivitiesMethod">
<Parameter name="Delta factor" type="unsignedFloat" value="0.001"/>
<Parameter name="Delta minimum" type="unsignedFloat" value="1e-012"/>
</Method>
</Task>
<Task key="Task_24" name="Moieties" type="moieties" scheduled="false" updateModel="false">
<Problem>
</Problem>
<Method name="Householder Reduction" type="Householder">
</Method>
</Task>
<Task key="Task_25" name="Cross Section" type="crosssection" scheduled="false" updateModel="false">
<Problem>
<Parameter name="StepNumber" type="unsignedInteger" value="100"/>
<Parameter name="StepSize" type="float" value="0.01"/>
<Parameter name="Duration" type="float" value="1"/>
<Parameter name="TimeSeriesRequested" type="bool" value="1"/>
<Parameter name="OutputStartTime" type="float" value="0"/>
<Parameter name="Output Event" type="bool" value="0"/>
<Parameter name="LimitCrossings" type="bool" value="0"/>
<Parameter name="NumCrossingsLimit" type="unsignedInteger" value="0"/>
<Parameter name="LimitOutTime" type="bool" value="0"/>
<Parameter name="LimitOutCrossings" type="bool" value="0"/>
<Parameter name="PositiveDirection" type="bool" value="1"/>
<Parameter name="NumOutCrossingsLimit" type="unsignedInteger" value="0"/>
<Parameter name="LimitUntilConvergence" type="bool" value="0"/>
<Parameter name="ConvergenceTolerance" type="float" value="1e-006"/>
<Parameter name="Threshold" type="float" value="0"/>
<Parameter name="DelayOutputUntilConvergence" type="bool" value="0"/>
<Parameter name="OutputConvergenceTolerance" type="float" value="1e-006"/>
<ParameterText name="TriggerExpression" type="expression">
</ParameterText>
<Parameter name="SingleVariable" type="cn" value=""/>
</Problem>
<Method name="Deterministic (LSODA)" type="Deterministic(LSODA)">
<Parameter name="Integrate Reduced Model" type="bool" value="0"/>
<Parameter name="Relative Tolerance" type="unsignedFloat" value="1e-006"/>
<Parameter name="Absolute Tolerance" type="unsignedFloat" value="1e-012"/>
<Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
</Method>
</Task>
<Task key="Task_26" name="Linear Noise Approximation" type="linearNoiseApproximation" scheduled="false" updateModel="false">
<Report reference="Report_17" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Steady-State" type="key" value="Task_14"/>
</Problem>
<Method name="Linear Noise Approximation" type="LinearNoiseApproximation">
</Method>
</Task>
</ListOfTasks>
<ListOfReports>
<Report key="Report_9" name="Steady-State" taskType="steadyState" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Footer>
<Object cn="CN=Root,Vector=TaskList[Steady-State]"/>
</Footer>
</Report>
<Report key="Report_10" name="Elementary Flux Modes" taskType="fluxMode" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Footer>
<Object cn="CN=Root,Vector=TaskList[Elementary Flux Modes],Object=Result"/>
</Footer>
</Report>
<Report key="Report_11" name="Optimization" taskType="optimization" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Optimization],Object=Description"/>
<Object cn="String=\[Function Evaluations\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Value\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Parameters\]"/>
</Header>
<Body>
<Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Function Evaluations"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Best Value"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Best Parameters"/>
</Body>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Optimization],Object=Result"/>
</Footer>
</Report>
<Report key="Report_12" name="Parameter Estimation" taskType="parameterFitting" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Object=Description"/>
<Object cn="String=\[Function Evaluations\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Value\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Parameters\]"/>
</Header>
<Body>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Function Evaluations"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Best Value"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Best Parameters"/>
</Body>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Object=Result"/>
</Footer>
</Report>
<Report key="Report_13" name="Metabolic Control Analysis" taskType="metabolicControlAnalysis" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Metabolic Control Analysis],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Metabolic Control Analysis],Object=Result"/>
</Footer>
</Report>
<Report key="Report_14" name="Lyapunov Exponents" taskType="lyapunovExponents" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Lyapunov Exponents],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Lyapunov Exponents],Object=Result"/>
</Footer>
</Report>
<Report key="Report_15" name="Time Scale Separation Analysis" taskType="timeScaleSeparationAnalysis" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Time Scale Separation Analysis],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Time Scale Separation Analysis],Object=Result"/>
</Footer>
</Report>
<Report key="Report_16" name="Sensitivities" taskType="sensitivities" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Sensitivities],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Sensitivities],Object=Result"/>
</Footer>
</Report>
<Report key="Report_17" name="Linear Noise Approximation" taskType="linearNoiseApproximation" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Linear Noise Approximation],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Linear Noise Approximation],Object=Result"/>
</Footer>
</Report>
<Report key="Report_18" name="Complete Time, Particle Numbers, Volumes, and Global Quantity Values" taskType="timeCourse" separator="	" precision="6">
<Comment>
A table of time, all species particle numbers, all compartment volumes, and all global quantity values (includes fixed ones).
</Comment>
<Table printTitle="1">
<Object cn="CN=Root,Model=Adaptacao,Reference=Time"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_III],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_III_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_IV],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaM],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[Ca_NCX],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[NCX],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[PMCA],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_PMCA],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_PMCA_Ca],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_PMCA],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_PMCA_Ca],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_PMCA],Reference=ParticleNumber"/>
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<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP1_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP1_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP1_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP2_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP3_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_IV_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP2_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP3_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_II_III_IV_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP2_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP3_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_III_IV_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP2_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP1_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP2_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP3_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP4_CNG],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP1_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP3_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CaCaM_I_II_III_IV_cAMP4_CNGopen],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[A],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[B],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[CACopen_tot],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[Ca],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[Ca_bulk],Reference=ParticleNumber"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Reference=Volume"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_adap2],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_adap1],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_cam],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kf_cam],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_cam2],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[ICAC],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[ICNG],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[ICNGICAC],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[Vm1],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_cac],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_I_II_CNG_Ca_coop],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_I_II_CNG_Ca],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_III_CNG_Ca],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_III_CNG_Ca_coop],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_IV_CNG_Ca],Reference=Value"/>
<Object cn="CN=Root,Model=Adaptacao,Vector=Values[kb_IV_CNG_Ca_coop],Reference=Value"/>
</Table>
</Report>
</ListOfReports>
<ListOfPlots>
<PlotSpecification name="Ca2+" type="Plot2D" active="1">
<Parameter name="log X" type="bool" value="0"/>
<Parameter name="log Y" type="bool" value="0"/>
<ListOfPlotItems>
<PlotItem name="Ca.ParticleNumber|Time" type="Curve2D">
<Parameter name="Color" type="string" value="auto"/>
<Parameter name="Line subtype" type="unsignedInteger" value="0"/>
<Parameter name="Line type" type="unsignedInteger" value="0"/>
<Parameter name="Line width" type="unsignedFloat" value="1"/>
<Parameter name="Recording Activity" type="string" value="during"/>
<Parameter name="Symbol subtype" type="unsignedInteger" value="0"/>
<ListOfChannels>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Reference=Time"/>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Vector=Compartments[Cilia_microdomain],Vector=Metabolites[Ca],Reference=ParticleNumber"/>
</ListOfChannels>
</PlotItem>
</ListOfPlotItems>
</PlotSpecification>
<PlotSpecification name="ICNG" type="Plot2D" active="1">
<Parameter name="log X" type="bool" value="0"/>
<Parameter name="log Y" type="bool" value="0"/>
<ListOfPlotItems>
<PlotItem name="Values[ICNG]|Time" type="Curve2D">
<Parameter name="Color" type="string" value="auto"/>
<Parameter name="Line subtype" type="unsignedInteger" value="0"/>
<Parameter name="Line type" type="unsignedInteger" value="0"/>
<Parameter name="Line width" type="unsignedFloat" value="1"/>
<Parameter name="Recording Activity" type="string" value="during"/>
<Parameter name="Symbol subtype" type="unsignedInteger" value="0"/>
<ListOfChannels>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Reference=Time"/>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Vector=Values[ICNG],Reference=Value"/>
</ListOfChannels>
</PlotItem>
</ListOfPlotItems>
</PlotSpecification>
<PlotSpecification name="ICAC" type="Plot2D" active="1">
<Parameter name="log X" type="bool" value="0"/>
<Parameter name="log Y" type="bool" value="0"/>
<ListOfPlotItems>
<PlotItem name="Values[ICAC]|Time" type="Curve2D">
<Parameter name="Color" type="string" value="auto"/>
<Parameter name="Line subtype" type="unsignedInteger" value="0"/>
<Parameter name="Line type" type="unsignedInteger" value="0"/>
<Parameter name="Line width" type="unsignedFloat" value="1"/>
<Parameter name="Recording Activity" type="string" value="during"/>
<Parameter name="Symbol subtype" type="unsignedInteger" value="0"/>
<ListOfChannels>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Reference=Time"/>
<ChannelSpec cn="CN=Root,Model=Adaptacao,Vector=Values[ICAC],Reference=Value"/>
</ListOfChannels>
</PlotItem>
</ListOfPlotItems>
</PlotSpecification>
</ListOfPlots>
<GUI>
</GUI>
</COPASI>