// Number of Gaps distributed in the model astrocyte
GapJunctionMaxNumber = NumberDendrites+1
objref gaps[GapJunctionMaxNumber]
NumberListSoma = 1
// Total number of geometrical objects
// NumberDendrites is a Number in the file of 3D reconstruction
SizeTotal = (NumberDendrites+NumberListSoma)*NumberLeaves+1
// Leaves
create LargeGlia[SizeTotal]
create SmallGlia[SizeTotal]
// Sets default initial params to soma and dendrites which doesn't depend on simulation.
proc setSomaDendrCommonParams() {
for i = 1, NumberDendrites-SeedNumber-1 {
dendrite[i] connect dendrite[i+SeedNumber](0), 1
access dendrite[i+SeedNumber]
{ L = 0.1 diam = 3 } // L and dim in um define the geometry of small seeds
pt3dclear()
}
soma {
Ra = 100 // Ohm cm
cm = 0.8 // uF/cm2
nseg = 10
insert pas
e_pas = -85 // mV
g_pas = 1/11150 // mS/cm2
insert k_ion
ko_k_ion=3
ki_k_ion=110
//insert ip3diffus
insert kir4
gkir_kir4=0
for i = 2, NumberDendrites {
gaps[i] = new Gap(0.5)
gaps[i].r = 100000
setpointer gaps[i].vgap, v(0.5)
}
}
// LengthControl=0
// diameterControl=0
for i = 0, NumberDendrites-1 dendrite[i] {
// if (i < 132 ) {
// LengthControl=LengthControl+dendrite[i].L
// print i,LengthControl, diameterControl, dendrite[i].diam
// }
Ra = 100 // Ohm cm
cm = 0.8 // uF/cm2
nseg = 10
insert pas
e_pas = -85 // mV
g_pas = 1/11150 // mS/cm2
insert k_ion
ko_k_ion=3
ki_k_ion=110
insert kir4
gkir_kir4=0
//insert ip3diffus
gaps[1] = new Gap(0.5)
gaps[1].r = 100000
setpointer gaps[1].vgap, v(0.5)
}
// Gap junction inside the astrocite
for i = 0, NumberDendrites-2 dendrite[i] {
setpointer gaps[2+i].vgap, dendrite[i].v(0.5)
}
setpointer gaps[1].vgap, soma.v(0.5)
}
// This part defines the topology of Astrocyte
// Connects leaves and stalks.
proc addLeaves() {
connect LargeGlia[0](0), dendrite[0](1)
for i = 0, NumberLeaves-1 {
connect SmallGlia[i](0), LargeGlia[i](1)
connect LargeGlia[i+1](0), SmallGlia[i](1)
}
for i = 1, NumberDendrites-1 {
connect LargeGlia[NumberLeaves*i+1](0), dendrite[i](1)
}
for i = NumberLeaves+1, NumberLeaves+NumberLeaves-1 {
for j = 0, NumberDendrites-2 {
connect SmallGlia[NumberLeaves*j+i](0), LargeGlia[NumberLeaves*j+i](1)
connect LargeGlia[NumberLeaves*j+i+1](0), SmallGlia[NumberLeaves*j+i](1)
}
}
}
// Sets default initial params to stalks and leaves which doesn't depend on simulation.
proc setLeavesCommonParams() {
for i = 0, SizeTotal-1 LargeGlia[i] {
insert pas
nseg = 1
Ra = 100 // Ohm cm
cm = 0.8 // uF/cm2
e_pas = -85 // mV
insert k_ion
ko_k_ion=3
ki_k_ion=110
insert kir4
gkir_kir4=0
}
for i = 0, SizeTotal-1 SmallGlia[i] {
insert pas
nseg = 1
Ra = 100 // Ohm cm
cm = 0.8 // uF/cm2
e_pas = -85 // mV
insert k_ion
ko_k_ion=3
ki_k_ion=110
insert kir4
gkir_kir4=0
// g_pas = 1/11150 // mho/cm2
}
}
// Initial all the astrocyte parameters.
proc initCell() {
setSomaDendrCommonParams()
addLeaves()
setLeavesCommonParams()
}
// initCell()