/*-------------------------------------------------------------- TEMPLATE FILE FOR DEFINING PALLIDIAL NEURONS - Parallel version -------------------------------------------------- One compartment model and currents derived from: Cooper and Nambu papers Dongchul C. Lee, Cleveland Clinic, 2005 May 2006 parallel code - PJ Hahn --------------------------------------------------------------*/ begintemplate pGPe // create a new template object public soma, synlist, connect2target, is_art objref synlist create soma proc init() { soma { diam = 60 // geometry L = 60 // so that area is about 10000 um2 nseg = 1 Ra = 200 cm = 1 insert myions //dummy mechanism used to set initial ion concentrations insert GPeA gnabar_GPeA = 0.04 //Fast Na gkdrbar_GPeA = 0.0042 // Delayed rectifier gkcabar_GPeA = 0.1e-3 //[S/cm2] gcatbar_GPeA = 6.7E-5 // T current kca_GPeA = 2 //Ca removal rate [1/ms] gl_GPeA = 4E-5 //Leakage current synlist = new List() synapses($1,$2,$3) // $1 numStrGpe, $2 numSTNGPe, $3 numGPeGPe } cai0_ca_ion = 5e-6 //mM cao0_ca_ion = 2 ki0_k_ion = 105 //calculated so that Nernst potential is same as in paper ko0_k_ion = 3 nao0_na_ion = 108 nai0_na_ion = 10 } proc connect2target() { //$o1 target object, $o2 returned NetCon soma $o2 = new NetCon(&v(1), $o1) } objref syn_ proc synapses() { // $1 numStrGpe, $2 numSTNGPe, $3 numGPeGPe // GABAergic striatal inputs // numStrGPe = for i=0,$1 - 1 { soma syn_ = new GABAa_S(.5) syn_.Cmax = 1 synlist.append(syn_) } // glutamatergic STN inputs // set in pBGconst numSTNGPe = for i=0,$2 - 1 { soma syn_ = new AMPA_S(.5) syn_.Cmax = 1 synlist.append(syn_) } // GABAergic GPe inputs // set in pBGconst numGPeGPe = for i=0,$3 - 1 { soma syn_ = new GABAa_S(.5) syn_.Cmax = 1 synlist.append(syn_) } } proc is_art() { return 0 } endtemplate pGPe