/*-------------------------------------------------------------- TEMPLATE FILE FOR DEFINING PALLIDIAL NEURONS - Parallel version -------------------------------------------------- One compartment model and currents derived from: Cooper and Nambu papers Dongchul C. Lee, Cleveland Clinic, 2005 This file is for GPi neuron, but the mechanism is from GPe A-type neuron. May 2006 parallel code - PJ Hahn --------------------------------------------------------------*/ begintemplate pGPi // create a new template object public soma, synlist, connect2target, is_art objref synlist create soma proc init() { soma { diam = 60 // geometry L = 60 // so that area is about 10000 um2 nseg = 1 Ra = 200 cm = 1 insert myions //dummy mechanism used to set initial ion concentrations insert GPeA kca_GPeA = 2 //Ca removal rate [1/ms] gkcabar_GPeA = 0.1e-3 //[S/cm2] gcatbar_GPeA = 6.7E-5 // T current gkdrbar_GPeA = 0.0042 // Delayed rectifier gnabar_GPeA = 0.04 //Fast Na gl_GPeA = 4E-5 //Leakage current synlist = new List() synapses($1,$2,$3) // $1 numStrGpi, $2 numSTNGPi, $3 numGPeGPi } cai0_ca_ion = 5e-6 //mM cao0_ca_ion = 2 ki0_k_ion = 105 //calculated so that Nernst potential is same as in paper ko0_k_ion = 3 nao0_na_ion = 108 nai0_na_ion = 10 numStrGPi_ = $1 numSTNGPi_ = $2 numGPeGPi_ = $3 } proc connect2target() { //$o1 target object, $o2 returned NetCon soma $o2 = new NetCon(&v(1), $o1) } objref syn_ proc synapses() { // $1 numStrGpi, $2 numSTNGPi, $3 numGPeGPi // GABAergic striatal inputs // in pBGconst numStrGPi = 7 for i=0,$1 - 1 { soma syn_ = new GABAa_S(.5) syn_.Cmax = 1 synlist.append(syn_) } // glutamatergic STN inputs // in pBGconst numSTNGPi = for i=0,$2 - 1 { soma syn_ = new AMPA_S(.5) syn_.Cmax = 1 synlist.append(syn_) } // GABAergic GPe inputs // in pBGconst numGPeGPi = for i=0,$3 - 1 { soma syn_ = new GABAa_S(.5) syn_.Cmax = 1 synlist.append(syn_) } } proc is_art() { return 0 } endtemplate pGPi