// Basic Neural Simulation Framework (BSNF)
//
// Copyright 2007 John L Baker. All rights reserved.
//
// This software is provided AS IS under the terms of the Open Source
// MIT License. See http://www.opensource.org/licenses/mit-license.php.
//
// File: test_baker_310.cpp
//
// Release: 1.0.0
// Author: John Baker
// Updated: 14 July 2006
//
// Description:
//
// Test homosynaptic plasticity for GLU synapses.
#include "test_baker_300.h"
#include "plasticity_glu_baker_2003.h"
using namespace std;
using namespace BNSF;
using namespace UOM;
using namespace BAKER_2003;
void test_baker_310()
{
cout<<"Test case 310 - homosynaptic LTD"<<endl;
SimTime tmax,tinj,t;
Number Iinj,freq;
Controller cont;
SSRMNeuron preNeuron;
Test300Neuron postNeuron;
AxonProcess* axon = preNeuron.axonProcess();
SSRMSoma* soma = postNeuron.soma();
NR2A_SynapticResp dummyNMDAR; // needed to get ndmar params
NMDARDepPlasticityRule* rule;
ExternalSpikeRecorder spikeRecorder ("test-baker-spikes.txt");
// Disable presynaptic plasticity for this test
postNeuron.soma()->ampa()->presynapticRule( NULL );
// Set the postsynaptic rule to test
postNeuron.soma()->ampa()->postsynapticRule(rule=new CA3_AC_STDPRule(&dummyNMDAR));
postNeuron.numericIdentifier(1);
preNeuron.numericIdentifier(2);
preNeuron.addProbe(&spikeRecorder);
postNeuron.addProbe(&spikeRecorder);
preNeuron.addToController(&cont);
postNeuron.addToController(&cont);
cont.start();
Synapse* syn = soma->ampa()->createSynapse(axon,1.0f);
Iinj = 1*nanoA;
tinj = 1*msec;
tmax = 3*minute;
freq = 3*Hz;
cout<<"Frequency (Hz) = "<<freq/Hz<<endl;
cout<<"Starting synapse weight = "<<soma->ampa()->synapseWeight(syn)<<endl;
for (t=0;t<tmax;t+=1/freq) {
cont.runUpTo(t);
cout<<"t = "<<t/sec
<<" (sec), synapse weight = "<<soma->ampa()->synapseWeight(syn)
<<" target weight = "<<rule->targetWeight(syn)<<endl;
preNeuron.soma()->Iinjected(Iinj);
cont.runForDuration(tinj);
preNeuron.soma()->Iinjected(0);
}
cout<<"Ending synapse weight (+ 0sec) = "<<soma->ampa()->synapseWeight(syn)<<endl;
cont.runForDuration(10*sec);
cout<<"Ending synapse weight (+10sec) = "<<soma->ampa()->synapseWeight(syn)<<endl;
cont.runForDuration(20*sec);
cout<<"Ending synapse weight (+30sec) = "<<soma->ampa()->synapseWeight(syn)<<endl;
cont.finish();
}