// (C) Armin Bahl, Jun 18 2009
// Simplified Geometry for layer 5 Pyramidal Neuron
////////////////////////////////////////////////////////////////////////////////////////////////
// The Geometry will fulfill these area conditions
// Surface areas were calculated from a detailed reconstruction from a Pyramidal Neuron
soma_area = 1682.96028429
basal_area = 7060.90626796
apicalshaftoblique_area = 9312.38528764
tuft_area = 9434.24861189
PI = 3.1415926535897932384
////////////////////////////////////////////////////////////////////////////////////////////////
// Create the Segments and connect them properly and set the number of compartments per Segment
create soma
create basal
create apical
create tuft
create hillock
create iseg
create axon
connect basal(0), soma(0.5)
connect apical(0), soma(1)
connect tuft(0), apical(1)
connect hillock(0), soma(0)
connect iseg(0), hillock(1)
connect axon(0), iseg(1)
soma nseg = 1
basal nseg = 1
apical nseg = 5
tuft nseg = 2
hillock nseg = 5
iseg nseg = 5
axon nseg = 1
////////////////////////////////////////////////////
// Define Sections
objref axon_list, axosomatic_list, apicaltree_list, apicalshaftoblique_list, tuft_list, soma_list, basal_list
axon_list = new SectionList()
axosomatic_list = new SectionList()
apicalshaftoblique_list = new SectionList()
apicaltree_list = new SectionList()
tuft_list = new SectionList()
soma_list = new SectionList()
basal_list = new SectionList()
hillock axon_list.append()
iseg axon_list.append()
axon axon_list.append()
soma axosomatic_list.append()
basal axosomatic_list.append()
hillock axosomatic_list.append()
iseg axosomatic_list.append()
axon axosomatic_list.append()
apical apicalshaftoblique_list.append()
apical apicaltree_list.append()
tuft apicaltree_list.append()
tuft tuft_list.append()
soma soma_list.append()
basal basal_list.append()
// As we do not have oblique dendrites in the reduced model this is the same (important for area calculation)
///////////////////////////////////////////////////////////
// Set the Parameters that were Found by the Geometry Optimization Algorithm
soma Ra = 82
basal L = 257
basal Ra = 734
apical L = 500
Ra_apical = 261
diam_apical = apicalshaftoblique_area/PI/apical.L
apical Ra = Ra_apical
tuft L = 499
tuft Ra = 527
proc recalculate_geometry() {
soma diam = L = sqrt(soma_area/PI)
basal diam = basal_area/PI/basal.L
apical diam = diam_apical
tuft diam = tuft_area/PI/tuft.L
}
recalculate_geometry()
////////////////////////////////////////////////
// Also append an Axon
hillock {
L = 20
diam(0:1) = 3.5:2.0
Ra = soma.Ra
}
iseg {
L = 25
diam(0:1) = 2.0:1.5
Ra = soma.Ra
}
axon {
L = 500
diam = 1.5
Ra = soma.Ra
}