//
// A model of cat spinal motoneuron
//
ndend=3
nnode=40
create soma, AH, IS, dend[ndend], node[nnode], myel[nnode]
proc topol() {
soma {
connect AH(0), (1)
connect dend[0](0), (0)
}
for i=1,ndend-1 {
connect dend[i](0), dend[i-1](1)
}
connect IS(0), AH(1)
connect myel[0](0), IS(1)
for i=0,nnode-2 {
connect node[i](0), myel[i](1)
connect myel[i+1](0), node[i](1)
}
connect node[nnode-1](0), myel[nnode-1](1)
}
proc geometry() {
soma {
diam=50
L=50
nseg=5
}
AH {
diam(0:1)=50:3.0
L=15
nseg=3
}
IS {
diam=3.0
L=30
nseg=11
}
forsec "dend" {
diam=50
L=1100
nseg=15
}
forsec "node" {
diam=6
L=4
nseg=1
}
forsec "myel" {
diam=7
L=200
nseg=5
}
}
proc biophysics() {
forall Ra=70
soma {
cm=1
insert Kdr
gkmax_Kdr=0.3
insert Naf_So
gnamax_Naf_So=0.03
insert Nap
gnamax_Nap=0.01
insert mAHP
gkcamax_mAHP=0.05
gcamax_mAHP=3e-5
insert lk
gl_lk=0.001
}
AH {
cm=1
insert Kdr
gkmax_Kdr(0:1)=0.3:1
insert Naf_So
gnamax_Naf_So(0:1)=0.03:0
insert mAHP
gkcamax_mAHP(0:1)=0.05:0
gcamax_mAHP(0:1)=3e-5:0
insert Naf_IS
gnamax_Naf_IS(0:1)=0:0.2
insert Nap
gnamax_Nap(0:1)=0.01:0.25
insert lk
gl_lk(0:1)=0.001:0.01
}
IS {
cm=1
insert Kdr
gkmax_Kdr=1
insert Naf_IS
gnamax_Naf_IS=0.2
insert Nap
gnamax_Nap=0.25
insert lk
gl_lk=0.01
}
forsec "dend" {
cm=1
insert pas
g_pas=0.0002
e_pas=-70
}
forsec "myel" {
cm=0.1
insert pas
g_pas=0.001
e_pas=-70
}
forsec "node" {
cm=1
insert K_No
gkmax_K_No=0.08
ek_K_No=-80
insert Naf_No
gnamax_Naf_No=0.4
insert Nap_No
gnamax_Nap_No=0.01
insert lk
gl_lk=0.007
el_lk=-80
}
dend[0] { // proximal dendrite holds ionic channels similar to soma, but density decreases
// in proximal-distal direction (range), it hasn't got pas mechanism
insert mAHP
gkcamax_mAHP(0:1)=0.05:0
gcamax_mAHP(0:1)=3e-5:0
insert Kdr
gkmax_Kdr(0:1)=0.3:0
insert Naf_So
gnamax_Naf_So(0:1)=0.03:0
insert Nap
gnamax_Nap(0:1)=0.01:0
insert lk
gl_lk(0:1)=0.001:0.0002
uninsert pas
}
}
topol()
geometry()
biophysics()