This is the readme for the model associated with the paper: Berzhanskaya J, Chernyy N, Gluckman BJ, Schiff SJ, Ascoli GA (2013) Modulation of hippocampal rhythms by subthreshold electric fields and network topology. J Comput Neurosci 34(3):369-389 This is the code that the paper authors used. This NEURON model simulates OPb network made of 20 Pyramidal, Oriens and Basket cells (60 total). Biophysically realistic Pyramidal cells have full 3D morphological structure, while Oriens and Basket cells have simplfied compartmental structure. Synaptic weight distribution on Pyramidal cells is modeled after Li and Ascoli (2006, 2008). Experimental data on the external electric field effects at the single cell level are collected using control circuits described in Gluckman et al. (1996, 2001). External electric field application is simulated after C. McIntyre and M. Robertson. Usage instructions: ------------------- Either auto-launch from ModelDB or download, extract the archive and compile the mod files with nrnivmodl (unix/linux) or mknrndll (pc or mac). (The file auto-launch will start is HipNetStart.hoc). If running by hand use "nrngui mosinit.hoc" (unix/linux) or double clicking mosinit.hoc (mswin) or dragging and dropping the mosinit.hoc file onto the nrngui icon (mac os x). Once the simulation has started three actions are required to run the network: 1. Select the network (Click the netwOPb button) 2. Set up electric field (Click the Uniform Field button) 3. Choose initial current injection (recommended 0.23-0.26 nA) (type 0.23 into the "Int Stim Amp (nA)" field in the "Internal Current Clamp" window) Current version runs in Neuron 7