/*-------------------------------------------------------------- TEMPLATE FILE FOR DEFINING CORTICAL PYRAMIDAL CELLS --------------------------------------------------- SIMPLIFIED NEURONS: - one compartment model and currents derived from: McCormick, D.A., Wang, Z. and Huguenard, J. Neurotransmitter control of neocortical neuronal activity and excitability. Cerebral Cortex 3: 387-398, 1993. - passive - HH: Traub - IM: m format Alain Destexhe, Laval University, 1995 --------------------------------------------------------------*/ begintemplate sPY // create a new template object public soma,all objref all create soma[1] proc init() { local v_potassium, v_sodium v_potassium = -100 // potassium reversal potential v_sodium = 50 // sodium reversal potential soma { Ra = 100 // geometry nseg = 1 diam = 96 L = 96 // so that area is about 29000 um2 cm = 1 insert pas // leak current e_pas = -70 g_pas = 0.0001 // Rin = 34 Meg // conversion with McC units: // g(S/cm2) = g(nS)*1e-9/29000e-8 // = g(nS) * 3.45e-6 insert hh2cx // Hodgin-Huxley INa and IK ek = v_potassium ena = v_sodium vtraub_hh2cx = -55 // Resting Vm, BJ was -55 gnabar_hh2cx = 0.05 // McCormick=15 muS, thal was 0.09 gkbar_hh2cx = 0.005 // spike duration of pyr cells insert im // M current taumax_im = 1000 gkbar_im = 7e-5 // Diego's IM (copyrighted) // insert iahp // alpha_iahp = 1.25e9 // beta_iahp = 0.001 // gkbar_iahp = 1.7e-5 // McCormick=5 nS // insert cad // calcium decay // depth_cad = 1 // McCormick= 0.1 um // taur_cad = 5 // McCormick=1 ms !!! // cainf_cad = 2.4e-4 // McCormick=0 // kt_cad = 0 // no pump } all = new SectionList() soma all.append() } endtemplate sPY