This is the README for the model associated with the paper: Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Gross RE, Grill WM (2012) Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation. J Neurophysiol 107:364-83 Thalamic Network Model Merrill J. Birdno May 2009 TC Neuron Derived from McIntyre et.el., 2004 BASIC INSTRUCTIONS: 1) You will need to use mknrn.dll (see NEURON documentation)(MAC or mswin) or nrnivmodl (unix/linux) to create a new 'special' file with the compiled .mod mechanisms. Copy this special file into the 'master' simulation directory included with the model. 2) ~Line 627 in DBSstim.hoc, you will see the line: indrt = strobj.tail(subdir,"ModelDirectory/","x") You will need to change "ModelDiretory/" to "SuperDirectory/" where SuperDirectory is the directory that contains the master directory and all of your sim run directories. Make sure the directory ends with a slash. 3) Use setup.q script to create multiple "sim" directories for your simulation runs and load the appropriate model/stimulus parameters. This will also copy your special file into the directories. 4) Run the model using the command: ./special DBSstim.hoc quit.hoc from inside each newly created directory. 5) DBSstim.hoc loads several parameter files at the beginning, which is why you need the nk, vsh.txt, etc. files in each run directory. 6) If you would like to custumize the extracellular stimulus trains played into the model, then you will need to generate Harmaline.dat, Poisson.dat, and Stim_x.dat files in master directory using generate_stim_poisson_harmaline.m file.