TITLE McCormick and Huguenard Na and K leak channels
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX tcleakdepol
NONSPECIFIC_CURRENT inal
USEION k READ ek WRITE ik
RANGE gnal, gkl, ena, minc , tau_m, stimon, nsm, iksub
POINTER vext, pmodyn : vext turns into a dummy variable to determine whether a stim pulse is ON
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gnal = 0.00000086 (mho/cm2)
gkl = 0.03 (mho/cm2)
m_inf = 1
mmin = 0
tau_m = 2000 (ms)
minc = 0.0025 (/ms)
stimon = 0
nsm = 1
: ek = -95 (mV)
ena = 45 (mV)
celsius (degC)
dt (ms)
v (mV)
}
STATE {
m
}
ASSIGNED {
ek (mV)
inal (mA/cm2)
iksub (mA/cm2)
ik (mA/cm2)
vext : vext turns into a dummy variable to determine whether a stim pulse is ON
pmodyn
}
BREAKPOINT {
SOLVE states METHOD euler
inal = gnal * (v - ena)
if (m < 0) {
m = 0
}
iksub = gkl * m * (v - ek)
ik = iksub
}
DERIVATIVE states { : exact Hodgkin-Huxley equations
eval_stimon(vext)
m' = (m_inf - m) / tau_m - nsm*pmodyn*minc
}
INITIAL {
m=m_inf
}
PROCEDURE eval_stimon(vext) { : vext turns into a dummy variable to determine whether a stim pulse is ON
if(vext==0) {
stimon=0
}else{
stimon=1
}
}