NEURON {
SUFFIX nakpump
USEION na READ nai WRITE ina
USEION k READ ko WRITE ik
USEION ATP READ ATPi WRITE iATP CHARGE 1
NONSPECIFIC_CURRENT i
RANGE imax, ik, ina, Kk, accna, acck
}
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
(molar) = (1/liter)
(mM) = (millimolar)
}
ASSIGNED {
ina (mA/cm2)
ik (mA/cm2)
accna (mA/cm2)
acck (mA/cm2)
iATP (mA/cm2)
i (mA/cm2)
ATPi (mM)
nai (mM)
ko (mM)
v (mV)
ipump (mA/cm2)
}
INITIAL {
accna = 0
acck = 0
}
PARAMETER {
: pump
imax = 0.1 (mA/cm2)
Kna = 22.0 (mM)
Kk = 3.5 (mM)
NaDiv = 3.0 (mM)
KDiv = 1.0 (mM)
ATPss = 2.59 (mM)
kATP = 0.58 (mM)
}
BREAKPOINT {
:ipump = imax / (pow(1 + 2. / ko, 2) * pow(1 + 7.7 / nai, 3))
ipump = imax * ((kATP + ATPss)/ATPss)*(ATPi/(kATP + ATPi)) / ( (1.0 + exp((Kna - nai)/NaDiv)) * (1.0 + exp( (Kk - ko)/KDiv) ) )
iATP = fabs(ipump)
i = -iATP
ina = (3 * ipump)
ik = (-2 * ipump)
accna = accna + ina
acck = acck + ik
}