: km.mod
: Potassium channel, Hodgkin-Huxley style kinetics
: Based on I-M (muscarinic K channel)
: Slow, noninactivating
: Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu
:
: modified to use CVode --Carl Gold 08/12/03
NEURON {
SUFFIX km
USEION k READ ek WRITE ik
RANGE n, gbar,ik
GLOBAL Ra, Rb, ninf, ntau
GLOBAL q10, temp, tadj, vmin, vmax
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
: (pS) = (picosiemens)
: (um) = (micron)
}
PARAMETER {
gbar = 0.03 (mho/cm2)
: gbar = 10 (pS/um2) : 0.03 mho/cm2
tha = -30 (mV) : v 1/2 for inf
qa = 9 (mV) : inf slope
Ra = 0.001 (/ms) : max act rate (slow)
Rb = 0.001 (/ms) : max deact rate (slow)
temp = 23 (degC) : original temp
q10 = 2.3 : temperature sensitivity
vmin = -120 (mV)
vmax = 100 (mV)
}
ASSIGNED {
celsius (degC)
v (mV)
ik (mA/cm2)
ek (mV)
ninf
ntau (ms)
tadj
}
STATE {
n
}
INITIAL {
tadj = q10^((celsius - temp)/10(degC)) :temperature adjustment
rates(v)
n = ninf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ik = tadj* gbar*n * (v - ek)
: ik = (1e-4) *tadj* gbar*n * (v - ek)
}
DERIVATIVE states {
rates(v)
n' = (ninf-n)/ntau
}
PROCEDURE rates(v(mV)) { :Computes rate and other constants at current v.
:Call once from HOC to initialize inf at resting v.
LOCAL a,b
a = Ra * (v - tha)*1(/mV) / (1 - exp(-(v - tha)/qa))
b = -Rb * (v - tha)*1(/mV) / (1 - exp((v - tha)/qa))
ntau = 1/(a+b)/tadj
ninf = a*ntau
}