/* Created by Language version: 6.0.2 */
/* NOT VECTORIZED */
#include <stdio.h>
#include <math.h>
#include "scoplib.h"
#undef PI
#include "md1redef.h"
#include "section.h"
#include "nrnoc_ml.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#undef exp
#define exp hoc_Exp
extern double hoc_Exp();
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define delta_t dt
#define gbar _p[0]
#define ik _p[1]
#define xs _p[2]
#define ys _p[3]
#define q10 _p[4]
#define T _p[5]
#define Dxs _p[6]
#define Dys _p[7]
#define _g _p[8]
#define _ion_ik *_ppvar[0].pval
#define _ion_dikdv *_ppvar[1].pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
extern double celsius;
extern double dt;
extern double t;
/* declaration of user functions */
static int _hoc_rates();
static int _mechtype;
extern int nrn_get_mechtype();
static _hoc_setdata() {
Prop *_prop, *hoc_getdata_range();
_prop = hoc_getdata_range("kdBG");
_p = _prop->param; _ppvar = _prop->dparam;
ret(1.);
}
/* connect user functions to hoc names */
static IntFunc hoc_intfunc[] = {
"setdata_kdBG", _hoc_setdata,
"rates_kdBG", _hoc_rates,
0, 0
};
/* declare global and static user variables */
#define Ky Ky_kdBG
double Ky = 0.0002;
#define gammay gammay_kdBG
double gammay = 0;
#define taoy taoy_kdBG
double taoy = 0;
#define taox taox_kdBG
double taox = 1;
#define vhalfy vhalfy_kdBG
double vhalfy = -73;
#define vhalfx vhalfx_kdBG
double vhalfx = -63;
#define xinf xinf_kdBG
double xinf = 0;
#define xtau xtau_kdBG
double xtau = 0;
#define yinf yinf_kdBG
double yinf = 0;
#define ytau ytau_kdBG
double ytau = 0;
#define zettay zettay_kdBG
double zettay = -2.5;
#define zettax zettax_kdBG
double zettax = 3;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"Ky_kdBG", "1/ms",
"gammay_kdBG", "1",
"zettax_kdBG", "1",
"zettay_kdBG", "1",
"vhalfx_kdBG", "mV",
"vhalfy_kdBG", "mV",
"taox_kdBG", "ms",
"taoy_kdBG", "ms",
"xtau_kdBG", "ms",
"ytau_kdBG", "ms",
"xinf_kdBG", "1",
"yinf_kdBG", "1",
"gbar_kdBG", "S/cm2",
"ik_kdBG", "mA/cm2",
0,0
};
static double v = 0;
static double xs0 = 0;
static double ys0 = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"Ky_kdBG", &Ky,
"gammay_kdBG", &gammay,
"zettax_kdBG", &zettax,
"zettay_kdBG", &zettay,
"vhalfx_kdBG", &vhalfx,
"vhalfy_kdBG", &vhalfy,
"taox_kdBG", &taox,
"taoy_kdBG", &taoy,
"xtau_kdBG", &xtau,
"ytau_kdBG", &ytau,
"xinf_kdBG", &xinf,
"yinf_kdBG", &yinf,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static nrn_alloc(), nrn_init(), nrn_state();
static nrn_cur(), nrn_jacob();
static int _ode_count(), _ode_map(), _ode_spec(), _ode_matsol();
extern int nrn_cvode_;
#define _cvode_ieq _ppvar[2]._i
/* connect range variables in _p that hoc is supposed to know about */
static char *_mechanism[] = {
"6.0.2",
"kdBG",
"gbar_kdBG",
0,
"ik_kdBG",
0,
"xs_kdBG",
"ys_kdBG",
0,
0};
static Symbol* _k_sym;
static nrn_alloc(_prop)
Prop *_prop;
{
Prop *prop_ion, *need_memb();
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 9);
/*initialize range parameters*/
gbar = 0.001;
_prop->param = _p;
_prop->param_size = 9;
_ppvar = nrn_prop_datum_alloc(_mechtype, 3);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_k_sym);
_ppvar[0].pval = &prop_ion->param[3]; /* ik */
_ppvar[1].pval = &prop_ion->param[4]; /* _ion_dikdv */
}
static _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
_KdBG_reg() {
int _vectorized = 0;
_initlists();
ion_reg("k", -10000.);
_k_sym = hoc_lookup("k_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, _vectorized);
_mechtype = nrn_get_mechtype(_mechanism[1]);
hoc_register_dparam_size(_mechtype, 3);
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 kdBG /home/jg/ModelosNeuron/ProgramsNeuronCA1_JG/CleanVersion_CA1_JG_15Mar09/mechanism/x86_64/KdBG.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static double FARADAY = 96485.3;
static double R = 8.31342;
static int _reset;
static char *modelname = "Kd current";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static _modl_cleanup(){ _match_recurse=1;}
static rates();
static int _ode_spec1(), _ode_matsol1();
static int _slist1[2], _dlist1[2];
static int states();
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
rates ( ) ;
Dxs = ( xinf - xs ) / xtau ;
Dys = ( yinf - ys ) / ytau ;
}
return _reset;
}
static int _ode_matsol1() {
rates ( ) ;
Dxs = Dxs / (1. - dt*( ( ( ( - 1.0 ) ) ) / xtau )) ;
Dys = Dys / (1. - dt*( ( ( ( - 1.0 ) ) ) / ytau )) ;
}
/*END CVODE*/
static int states () {_reset=0;
{
rates ( ) ;
xs = xs + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / xtau)))*(- ( ( ( xinf ) ) / xtau ) / ( ( ( ( - 1.0) ) ) / xtau ) - xs) ;
ys = ys + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / ytau)))*(- ( ( ( yinf ) ) / ytau ) / ( ( ( ( - 1.0) ) ) / ytau ) - ys) ;
}
return 0;
}
static int rates ( ) {
double _la , _lb ;
_la = q10 * exp ( ( 1.0e-3 ) * zettax * ( v - vhalfx ) * FARADAY / ( R * T ) ) ;
_lb = q10 * exp ( ( 1.0e-3 ) * - zettax * ( v - vhalfx ) * FARADAY / ( R * T ) ) ;
xinf = _la / ( _la + _lb ) ;
xtau = taox ;
_la = q10 * Ky * exp ( ( 1.0e-3 ) * zettay * gammay * ( v - vhalfy ) * FARADAY / ( R * T ) ) ;
_lb = q10 * Ky * exp ( ( 1.0e-3 ) * - zettay * ( 1.0 - gammay ) * ( v - vhalfy ) * FARADAY / ( R * T ) ) ;
yinf = _la / ( _la + _lb ) ;
ytau = 1.0 / ( _la + _lb ) + taoy ;
return 0; }
static int _hoc_rates() {
double _r;
_r = 1.;
rates ( ) ;
ret(_r);
}
static int _ode_count(_type) int _type;{ return 2;}
static int _ode_spec(_nd, _pp, _ppd) Node* _nd; double* _pp; Datum* _ppd; {
_p = _pp; _ppvar = _ppd; v = NODEV(_nd);
_ode_spec1();
}
static int _ode_map(_ieq, _pv, _pvdot, _pp, _ppd, _atol, _type) int _ieq, _type; double** _pv, **_pvdot, *_pp, *_atol; Datum* _ppd; {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 2; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static int _ode_matsol(_nd, _pp, _ppd) Node* _nd; double* _pp; Datum* _ppd; {
_p = _pp; _ppvar = _ppd; v = NODEV(_nd);
_ode_matsol1();
}
static initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
xs = xs0;
ys = ys0;
{
T = celsius + 273.15 ;
q10 = pow( 1.0 , ( ( celsius - 35.0 ) / 10.0 ) ) ;
rates ( ) ;
xs = xinf ;
ys = yinf ;
}
_sav_indep = t; t = _save;
}
}
static nrn_init(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
initmodel();
}}
static double _nrn_current(_v) double _v;{double _current=0.;v=_v;{ {
ik = gbar * pow( xs , 4.0 ) * pow( ys , 4.0 ) * ( v + 95.0 ) ;
}
_current += ik;
} return _current;
}
static nrn_cur(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_g = _nrn_current(_v + .001);
{ static double _dik;
_dik = ik;
_rhs = _nrn_current(_v);
_ion_dikdv += (_dik - ik)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ik += ik ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static nrn_jacob(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static nrn_state(_ml, _type) _Memb_list* _ml; int _type;{
double _break, _save;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_break = t + .5*dt; _save = t; delta_t = dt;
v=_v;
{
{ {
for (; t < _break; t += delta_t) {
error = states();
if(error){fprintf(stderr,"at line 56 in file KdBG.mod:\n SOLVE states METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
}}
t = _save;
} }}
}
static terminal(){}
static _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(xs) - _p; _dlist1[0] = &(Dxs) - _p;
_slist1[1] = &(ys) - _p; _dlist1[1] = &(Dys) - _p;
_first = 0;
}