/* Created by Language version: 6.0.2 */
/* NOT VECTORIZED */
#include <stdio.h>
#include <math.h>
#include "scoplib.h"
#undef PI
#include "md1redef.h"
#include "section.h"
#include "nrnoc_ml.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#undef exp
#define exp hoc_Exp
extern double hoc_Exp();
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define delta_t dt
#define gkabar _p[0]
#define ik _p[1]
#define gka _p[2]
#define n _p[3]
#define l _p[4]
#define ek _p[5]
#define Dn _p[6]
#define Dl _p[7]
#define _g _p[8]
#define _ion_ek *_ppvar[0].pval
#define _ion_ik *_ppvar[1].pval
#define _ion_dikdv *_ppvar[2].pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
extern double celsius;
extern double dt;
extern double t;
/* declaration of user functions */
static int _hoc_alpl();
static int _hoc_alpn();
static int _hoc_betl();
static int _hoc_betn();
static int _hoc_rates();
static int _mechtype;
extern int nrn_get_mechtype();
static _hoc_setdata() {
Prop *_prop, *hoc_getdata_range();
_prop = hoc_getdata_range("kad");
_p = _prop->param; _ppvar = _prop->dparam;
ret(1.);
}
/* connect user functions to hoc names */
static IntFunc hoc_intfunc[] = {
"setdata_kad", _hoc_setdata,
"alpl_kad", _hoc_alpl,
"alpn_kad", _hoc_alpn,
"betl_kad", _hoc_betl,
"betn_kad", _hoc_betn,
"rates_kad", _hoc_rates,
0, 0
};
#define alpl alpl_kad
#define alpn alpn_kad
#define betl betl_kad
#define betn betn_kad
extern double alpl();
extern double alpn();
extern double betl();
extern double betn();
/* declare global and static user variables */
#define a0n a0n_kad
double a0n = 0.1;
#define gml gml_kad
double gml = 1;
#define gmn gmn_kad
double gmn = 0.39;
#define lmin lmin_kad
double lmin = 2;
#define linf linf_kad
double linf = 0;
#define nmin nmin_kad
double nmin = 0.1;
#define ninf ninf_kad
double ninf = 0;
#define pw pw_kad
double pw = -1;
#define q10 q10_kad
double q10 = 5;
#define qq qq_kad
double qq = 5;
#define tq tq_kad
double tq = -40;
#define taun taun_kad
double taun = 0;
#define taul taul_kad
double taul = 0;
#define vhalfl vhalfl_kad
double vhalfl = -56;
#define vhalfn vhalfn_kad
double vhalfn = -1;
#define zetal zetal_kad
double zetal = 3;
#define zetan zetan_kad
double zetan = -1.8;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"vhalfn_kad", "mV",
"vhalfl_kad", "mV",
"a0n_kad", "/ms",
"zetan_kad", "1",
"zetal_kad", "1",
"gmn_kad", "1",
"gml_kad", "1",
"lmin_kad", "ms",
"nmin_kad", "ms",
"pw_kad", "1",
"tq_kad", "mV",
"qq_kad", "mV",
"taul_kad", "ms",
"taun_kad", "ms",
"gkabar_kad", "mho/cm2",
"ik_kad", "mA/cm2",
"gka_kad", "mho/cm2",
0,0
};
static double l0 = 0;
static double n0 = 0;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"vhalfn_kad", &vhalfn,
"vhalfl_kad", &vhalfl,
"a0n_kad", &a0n,
"zetan_kad", &zetan,
"zetal_kad", &zetal,
"gmn_kad", &gmn,
"gml_kad", &gml,
"lmin_kad", &lmin,
"nmin_kad", &nmin,
"pw_kad", &pw,
"tq_kad", &tq,
"qq_kad", &qq,
"q10_kad", &q10,
"ninf_kad", &ninf,
"linf_kad", &linf,
"taul_kad", &taul,
"taun_kad", &taun,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static nrn_alloc(), nrn_init(), nrn_state();
static nrn_cur(), nrn_jacob();
static int _ode_count(), _ode_map(), _ode_spec(), _ode_matsol();
extern int nrn_cvode_;
#define _cvode_ieq _ppvar[3]._i
/* connect range variables in _p that hoc is supposed to know about */
static char *_mechanism[] = {
"6.0.2",
"kad",
"gkabar_kad",
0,
"ik_kad",
"gka_kad",
0,
"n_kad",
"l_kad",
0,
0};
static Symbol* _k_sym;
static nrn_alloc(_prop)
Prop *_prop;
{
Prop *prop_ion, *need_memb();
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 9);
/*initialize range parameters*/
gkabar = 0;
_prop->param = _p;
_prop->param_size = 9;
_ppvar = nrn_prop_datum_alloc(_mechtype, 4);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_k_sym);
nrn_promote(prop_ion, 0, 1);
_ppvar[0].pval = &prop_ion->param[0]; /* ek */
_ppvar[1].pval = &prop_ion->param[3]; /* ik */
_ppvar[2].pval = &prop_ion->param[4]; /* _ion_dikdv */
}
static _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
_kadist_reg() {
int _vectorized = 0;
_initlists();
ion_reg("k", -10000.);
_k_sym = hoc_lookup("k_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, _vectorized);
_mechtype = nrn_get_mechtype(_mechanism[1]);
hoc_register_dparam_size(_mechtype, 4);
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 kad /home/jg/ModelosNeuron/ProgramsNeuronCA1_JG/CleanVersion_CA1_JG_15Mar09/mechanism/x86_64/kadist.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static double _lqt ;
static int _reset;
static char *modelname = "K-A channel from Klee Ficker and Heinemann";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static _modl_cleanup(){ _match_recurse=1;}
static rates();
static int _ode_spec1(), _ode_matsol1();
static int _slist1[2], _dlist1[2];
static int states();
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
rates ( v ) ;
Dn = ( ninf - n ) / taun ;
Dl = ( linf - l ) / taul ;
}
return _reset;
}
static int _ode_matsol1() {
rates ( v ) ;
Dn = Dn / (1. - dt*( ( ( ( - 1.0 ) ) ) / taun )) ;
Dl = Dl / (1. - dt*( ( ( ( - 1.0 ) ) ) / taul )) ;
}
/*END CVODE*/
static int states () {_reset=0;
{
rates ( v ) ;
n = n + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / taun)))*(- ( ( ( ninf ) ) / taun ) / ( ( ( ( - 1.0) ) ) / taun ) - n) ;
l = l + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / taul)))*(- ( ( ( linf ) ) / taul ) / ( ( ( ( - 1.0) ) ) / taul ) - l) ;
}
return 0;
}
static int rates ( _lv )
double _lv ;
{
double _la ;
_la = alpn ( _lv ) ;
ninf = 1.0 / ( 1.0 + _la ) ;
taun = betn ( _lv ) / ( _lqt * a0n * ( 1.0 + _la ) ) ;
if ( taun < nmin ) {
taun = nmin ;
}
_la = alpl ( _lv ) ;
linf = 1.0 / ( 1.0 + _la ) ;
taul = 0.26 * ( _lv + 50.0 ) ;
if ( taul < lmin ) {
taul = lmin ;
}
return 0; }
static int _hoc_rates() {
double _r;
_r = 1.;
rates ( *getarg(1) ) ;
ret(_r);
}
double alpn ( _lv )
double _lv ;
{
double _lalpn;
double _lzeta ;
_lzeta = zetan + pw / ( 1.0 + exp ( ( _lv - tq ) / qq ) ) ;
_lalpn = exp ( 1.e-3 * _lzeta * ( _lv - vhalfn ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ;
return _lalpn;
}
static int _hoc_alpn() {
double _r;
_r = alpn ( *getarg(1) ) ;
ret(_r);
}
double betn ( _lv )
double _lv ;
{
double _lbetn;
double _lzeta ;
_lzeta = zetan + pw / ( 1.0 + exp ( ( _lv - tq ) / qq ) ) ;
_lbetn = exp ( 1.e-3 * _lzeta * gmn * ( _lv - vhalfn ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ;
return _lbetn;
}
static int _hoc_betn() {
double _r;
_r = betn ( *getarg(1) ) ;
ret(_r);
}
double alpl ( _lv )
double _lv ;
{
double _lalpl;
_lalpl = exp ( 1.e-3 * zetal * ( _lv - vhalfl ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ;
return _lalpl;
}
static int _hoc_alpl() {
double _r;
_r = alpl ( *getarg(1) ) ;
ret(_r);
}
double betl ( _lv )
double _lv ;
{
double _lbetl;
_lbetl = exp ( 1.e-3 * zetal * gml * ( _lv - vhalfl ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ;
return _lbetl;
}
static int _hoc_betl() {
double _r;
_r = betl ( *getarg(1) ) ;
ret(_r);
}
static int _ode_count(_type) int _type;{ return 2;}
static int _ode_spec(_nd, _pp, _ppd) Node* _nd; double* _pp; Datum* _ppd; {
_p = _pp; _ppvar = _ppd; v = NODEV(_nd);
ek = _ion_ek;
_ode_spec1();
}
static int _ode_map(_ieq, _pv, _pvdot, _pp, _ppd, _atol, _type) int _ieq, _type; double** _pv, **_pvdot, *_pp, *_atol; Datum* _ppd; {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 2; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static int _ode_matsol(_nd, _pp, _ppd) Node* _nd; double* _pp; Datum* _ppd; {
_p = _pp; _ppvar = _ppd; v = NODEV(_nd);
ek = _ion_ek;
_ode_matsol1();
}
static initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
l = l0;
n = n0;
{
_lqt = pow( q10 , ( ( celsius - 24.0 ) / 10.0 ) ) ;
rates ( v ) ;
n = ninf ;
l = linf ;
}
_sav_indep = t; t = _save;
}
}
static nrn_init(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
ek = _ion_ek;
initmodel();
}}
static double _nrn_current(_v) double _v;{double _current=0.;v=_v;{ {
ik = gkabar * n * l * ( v - ek ) ;
}
_current += ik;
} return _current;
}
static nrn_cur(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
ek = _ion_ek;
_g = _nrn_current(_v + .001);
{ static double _dik;
_dik = ik;
_rhs = _nrn_current(_v);
_ion_dikdv += (_dik - ik)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ik += ik ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static nrn_jacob(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static nrn_state(_ml, _type) _Memb_list* _ml; int _type;{
double _break, _save;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_break = t + .5*dt; _save = t; delta_t = dt;
v=_v;
{
ek = _ion_ek;
{ {
for (; t < _break; t += delta_t) {
error = states();
if(error){fprintf(stderr,"at line 73 in file kadist.mod:\n: ik = gkabar*n*l*(v+70)\n"); nrn_complain(_p); abort_run(error);}
}}
t = _save;
} }}
}
static terminal(){}
static _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(n) - _p; _dlist1[0] = &(Dn) - _p;
_slist1[1] = &(l) - _p; _dlist1[1] = &(Dl) - _p;
_first = 0;
}