/* Created by Language version: 6.0.2 */
/* NOT VECTORIZED */
#include <stdio.h>
#include <math.h>
#include "scoplib.h"
#undef PI
#include "md1redef.h"
#include "section.h"
#include "nrnoc_ml.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#undef exp
#define exp hoc_Exp
extern double hoc_Exp();
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define delta_t dt
#define gcabar _p[0]
#define ica _p[1]
#define m _p[2]
#define h _p[3]
#define ecar _p[4]
#define inf (_p + 5)
#define fac (_p + 7)
#define tau (_p + 9)
#define cai _p[11]
#define cao _p[12]
#define Dm _p[13]
#define Dh _p[14]
#define _g _p[15]
#define _ion_cai *_ppvar[0].pval
#define _ion_cao *_ppvar[1].pval
#define _ion_ica *_ppvar[2].pval
#define _ion_dicadv *_ppvar[3].pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
extern double celsius;
extern double dt;
extern double t;
/* declaration of user functions */
static int _hoc_rates();
static int _hoc_varss();
static int _hoc_vartau();
static int _mechtype;
extern int nrn_get_mechtype();
static _hoc_setdata() {
Prop *_prop, *hoc_getdata_range();
_prop = hoc_getdata_range("somacar");
_p = _prop->param; _ppvar = _prop->dparam;
ret(1.);
}
/* connect user functions to hoc names */
static IntFunc hoc_intfunc[] = {
"setdata_somacar", _hoc_setdata,
"rates_somacar", _hoc_rates,
"varss_somacar", _hoc_varss,
"vartau_somacar", _hoc_vartau,
0, 0
};
#define varss varss_somacar
#define vartau vartau_somacar
extern double varss();
extern double vartau();
/* declare global and static user variables */
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"gcabar_somacar", "mho/cm2",
"ica_somacar", "mA/cm2",
0,0
};
static double h0 = 0;
static double m0 = 0;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static nrn_alloc(), nrn_init(), nrn_state();
static nrn_cur(), nrn_jacob();
static int _ode_count(), _ode_map(), _ode_spec(), _ode_matsol();
extern int nrn_cvode_;
#define _cvode_ieq _ppvar[4]._i
/* connect range variables in _p that hoc is supposed to know about */
static char *_mechanism[] = {
"6.0.2",
"somacar",
"gcabar_somacar",
0,
"ica_somacar",
0,
"m_somacar",
"h_somacar",
0,
0};
static Symbol* _ca_sym;
static nrn_alloc(_prop)
Prop *_prop;
{
Prop *prop_ion, *need_memb();
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 16);
/*initialize range parameters*/
gcabar = 0;
_prop->param = _p;
_prop->param_size = 16;
_ppvar = nrn_prop_datum_alloc(_mechtype, 5);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_ca_sym);
nrn_promote(prop_ion, 1, 0);
_ppvar[0].pval = &prop_ion->param[1]; /* cai */
_ppvar[1].pval = &prop_ion->param[2]; /* cao */
_ppvar[2].pval = &prop_ion->param[3]; /* ica */
_ppvar[3].pval = &prop_ion->param[4]; /* _ion_dicadv */
}
static _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
_somacar_reg() {
int _vectorized = 0;
_initlists();
ion_reg("ca", -10000.);
_ca_sym = hoc_lookup("ca_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, _vectorized);
_mechtype = nrn_get_mechtype(_mechanism[1]);
hoc_register_dparam_size(_mechtype, 5);
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 somacar /home/jg/ModelosNeuron/ProgramsNeuronCA1_JG/CleanVersion_CA1_JG_15Mar09/mechanism/x86_64/somacar.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static double FARADAY = 96485.3;
static double R = 8.31342;
static int _reset;
static char *modelname = "Ca R-type channel with medium threshold for activation";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static _modl_cleanup(){ _match_recurse=1;}
static rates();
static int _ode_spec1(), _ode_matsol1();
static int _slist1[2], _dlist1[2];
static int states();
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
rates ( v ) ;
Dm = ( inf [ 0 ] - m ) / tau [ 0 ] ;
Dh = ( inf [ 1 ] - h ) / tau [ 1 ] ;
}
return _reset;
}
static int _ode_matsol1() {
rates ( v ) ;
Dm = Dm / (1. - dt*( ( ( ( - 1.0 ) ) ) / tau[0] )) ;
Dh = Dh / (1. - dt*( ( ( ( - 1.0 ) ) ) / tau[1] )) ;
}
/*END CVODE*/
static int states () {_reset=0;
{
rates ( v ) ;
m = m + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / tau[0])))*(- ( ( ( inf[0] ) ) / tau[0] ) / ( ( ( ( - 1.0) ) ) / tau[0] ) - m) ;
h = h + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / tau[1])))*(- ( ( ( inf[1] ) ) / tau[1] ) / ( ( ( ( - 1.0) ) ) / tau[1] ) - h) ;
}
return 0;
}
static int rates ( _lv )
double _lv ;
{
{int _li ;for ( _li = 0 ; _li <= 1 ; _li ++ ) {
tau [ _li ] = vartau ( ((double) _li ) ) ;
inf [ _li ] = varss ( _lv , ((double) _li ) ) ;
} }
return 0; }
static int _hoc_rates() {
double _r;
_r = 1.;
rates ( *getarg(1) ) ;
ret(_r);
}
double varss ( _lv , _li )
double _lv , _li ;
{
double _lvarss;
if ( _li == 0.0 ) {
_lvarss = 1.0 / ( 1.0 + exp ( ( _lv + 60.0 ) / ( - 3.0 ) ) ) ;
}
else if ( _li == 1.0 ) {
_lvarss = 1.0 / ( 1.0 + exp ( ( _lv + 62.0 ) / ( 1.0 ) ) ) ;
}
return _lvarss;
}
static int _hoc_varss() {
double _r;
_r = varss ( *getarg(1) , *getarg(2) ) ;
ret(_r);
}
double vartau ( _li )
double _li ;
{
double _lvartau;
if ( _li == 0.0 ) {
_lvartau = 100.0 ;
}
else if ( _li == 1.0 ) {
_lvartau = 5.0 ;
}
return _lvartau;
}
static int _hoc_vartau() {
double _r;
_r = vartau ( *getarg(1) ) ;
ret(_r);
}
static int _ode_count(_type) int _type;{ return 2;}
static int _ode_spec(_nd, _pp, _ppd) Node* _nd; double* _pp; Datum* _ppd; {
_p = _pp; _ppvar = _ppd; v = NODEV(_nd);
cai = _ion_cai;
cao = _ion_cao;
_ode_spec1();
}
static int _ode_map(_ieq, _pv, _pvdot, _pp, _ppd, _atol, _type) int _ieq, _type; double** _pv, **_pvdot, *_pp, *_atol; Datum* _ppd; {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 2; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static int _ode_matsol(_nd, _pp, _ppd) Node* _nd; double* _pp; Datum* _ppd; {
_p = _pp; _ppvar = _ppd; v = NODEV(_nd);
cai = _ion_cai;
cao = _ion_cao;
_ode_matsol1();
}
static initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
h = h0;
m = m0;
{
m = 0.0 ;
h = 1.0 ;
rates ( v ) ;
}
_sav_indep = t; t = _save;
}
}
static nrn_init(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
cai = _ion_cai;
cao = _ion_cao;
initmodel();
}}
static double _nrn_current(_v) double _v;{double _current=0.;v=_v;{ {
ecar = ( 1e3 ) * ( R * ( celsius + 273.15 ) ) / ( 2.0 * FARADAY ) * log ( cao / cai ) ;
ica = gcabar * m * m * m * h * ( v - ecar ) ;
}
_current += ica;
} return _current;
}
static nrn_cur(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
cai = _ion_cai;
cao = _ion_cao;
_g = _nrn_current(_v + .001);
{ static double _dica;
_dica = ica;
_rhs = _nrn_current(_v);
_ion_dicadv += (_dica - ica)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ica += ica ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static nrn_jacob(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static nrn_state(_ml, _type) _Memb_list* _ml; int _type;{
double _break, _save;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_break = t + .5*dt; _save = t; delta_t = dt;
v=_v;
{
cai = _ion_cai;
cao = _ion_cao;
{ {
for (; t < _break; t += delta_t) {
error = states();
if(error){fprintf(stderr,"at line 55 in file somacar.mod:\n SOLVE states METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
}}
t = _save;
} }}
}
static terminal(){}
static _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(m) - _p; _dlist1[0] = &(Dm) - _p;
_slist1[1] = &(h) - _p; _dlist1[1] = &(Dh) - _p;
_first = 0;
}