COMMENT
K accum
ENDCOMMENT
NEURON {
SUFFIX kum
USEION k READ ik WRITE ko, ki
NONSPECIFIC_CURRENT i
RANGE depthko,depthki, kmax, irest, ko, ki, tau1, tau2, tau3, tau4
}
UNITS {
(mM) = (milli/liter)
(mA) = (milliamp)
F = (faraday) (coulombs)
}
PARAMETER {
depthko = 0.1 (um) : assume volume = area*depth
: depthki = diam
irest = 0 (mA/cm2) : to be initialized in hoc
tau1 = 2 (ms)
tau2 = 900 (ms)
tau3 = 1150 (ms)
tau4 = 1150 (ms)
diam (um)
}
ASSIGNED {
ik (mA/cm2)
kmax
i (mA/cm2)
}
STATE {
ko (mM)
ki (mM)
}
INITIAL {
ko=5
ko0=5
ki0=150
ki=150
: kmaxko=ko
: kmaxki=ki
}
BREAKPOINT {
SOLVE integrate METHOD derivimplicit
: if (ko>kmax) {kmaxko=ko}
: if (ki>kmax) {kmaxki=ki}
i=0
}
DERIVATIVE integrate {
ko' = ((ik-irest)/depthko/F*(1e4))/tau1 - (ko-ko0)/tau2 - (ko-ko0)/tau4
ki' = -((ik-irest)/depthko/F*(1e4))/tau1 + (ko - ko0)/tau2 - (ki - ki0)/tau3
}