TITLE CA1 KM channel from Mala Shah
: M. Migliore June 2006
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
FARADAY = 96485.332 (coul)
R = 8.3144626 (joule/K)
T = 273.15 (K)
KTOMV = .0853 (mV/K)
}
PARAMETER {
v (mV)
:ek
celsius (degC)
gbar=.0001 (mho/cm2)
vhalfl=-40 (mV)
kl=-10
vhalft=-42 (mV)
a0t=0.003 (/ms)
zetat=7 (1)
gmt=.4 (1)
q10=5
b0=60
ggk
ko0=5 (mM)
ki0=150 (mM)
ko=5 (mM)
ki=150 (mM)
nfact =1 (mV)
st=1
sh =0
}
NEURON {
SUFFIX kmb
USEION k READ ki, ko WRITE ik
RANGE gbar,ik, sh, ggk
GLOBAL inf, tau
}
STATE {
m
}
ASSIGNED {
ik (mA/cm2)
inf
tau
taua
taub
}
INITIAL {
rate(v)
nfact=-1000*R*(273.15+celsius)/FARADAY
ggk=nfact*(log(ki/ko))
m=inf
}
BREAKPOINT {
SOLVE state METHOD cnexp
ggk=nfact*(log(ki/ko))
ik = gbar*m^st*(v-ggk)
}
FUNCTION alpt(v(mV)) {
alpt = exp(0.0378*zetat*(v-vhalft-sh))
}
FUNCTION bett(v(mV)) {
bett = exp(0.0378*zetat*gmt*(v-vhalft-sh))
}
DERIVATIVE state {
rate(v)
m' = (inf - m)/tau
}
PROCEDURE rate(v (mV)) { :callable from hoc
LOCAL a,qt
qt=q10^((celsius-35)/10)
inf = (1/(1 + exp((v-vhalfl-sh)/kl)))
a = alpt(v)
tau = b0 + bett(v)/(a0t*(1+a))
}