# Model files in NEURON simulation environment For the paper: **The accumulation of extracellular K+ as in vivo model of epilepsy in CA1 pyramidal neurons** by Valentina Carpentieri, Christophe Bernard, and Michele Migliore --- ## Usage 1. **Download the files.** 2. **Compile the mod files** on the command line: ```sh nrnivmodl mechanisms ``` 3. **Install the NEURON simulation environment:** [https://nrn.readthedocs.io/en/8.2.6/](https://nrn.readthedocs.io/en/8.2.6/) 4. **To run the code directly** on the command line: ```sh nrniv ctrl_high_w.hoc ``` In this case, no new directories are created. --- Questions on how to use this model should be directed to [michele.migliore@cnr.it](mailto:michele.migliore@cnr.it)