TITLE I-h channel from Magee 1998
: Modified to make it slower according to SfN 2006 Poster 342.23.
: The peak activation time constant of Ih is around 100ms, around
: twice slower than that at CA1. And vhalf is around -89 mV, which
: is similar to what one sees in CA1 dendrites
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
ehd (mV)
celsius (degC)
ghdbar=.0001 (mho/cm2)
vhalfl=-89 (mV)
kl=-8
vhalft=-75 (mV)
a0t=0.005 (/ms) :original 0.011
zetat=2.2 (1)
gmt=.4 (1)
q10=4.5
qtl=1
}
NEURON {
SUFFIX hd
NONSPECIFIC_CURRENT i
RANGE ghdbar, vhalfl
GLOBAL linf,taul
}
STATE {
l
}
ASSIGNED {
i (mA/cm2)
linf
taul
ghd
}
INITIAL {
rate(v)
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ghd = ghdbar*l
i = ghd*(v-ehd)
}
FUNCTION alpt(v(mV)) {
alpt = exp(0.0378*zetat*(v-vhalft))
}
FUNCTION bett(v(mV)) {
bett = exp(0.0378*zetat*gmt*(v-vhalft))
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rate(v)
l' = (linf - l)/taul
}
PROCEDURE rate(v (mV)) { :callable from hoc
LOCAL a,qt
qt=q10^((celsius-33)/10)
a = alpt(v)
linf = 1/(1 + exp(-(v-vhalfl)/kl))
: linf = 1/(1+ alpl(v))
taul = bett(v)/(qtl*qt*a0t*(1+a))
}