NEURON {
SUFFIX MN_kSlow
USEION k READ ek WRITE ik
RANGE gmax, ik
RANGE alpha_A, alpha_B, alpha_C, alpha_D, alpha_E
RANGE beta_A, beta_B, beta_C, beta_D, beta_E
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
}
PARAMETER {
gmax = 0 (S/cm2)
alpha_A = 0.2
alpha_B = 0.0
alpha_C = 1.0
alpha_D = -2.96
alpha_E = -7.74
beta_A = 0.05
beta_B = 0.0
beta_C = 1.0
beta_D = -14.07
beta_E = 6.1
}
ASSIGNED {
v (mV)
ek (mV)
ik (mA/cm2)
ks_ninf
ks_ntau (ms)
}
STATE {
n
}
INITIAL {
ek = -80.0
rates()
n = ks_ninf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gmax * n * (v - ek)
}
DERIVATIVE states {
rates()
n' = ( ks_ninf - n ) / ks_ntau
}
UNITSOFF
PROCEDURE rates() {LOCAL alpha_n, beta_n
:alpha_n = 0.2/(1.0 + exp((-2.96+v)/-7.74))
:beta_n = 0.05/(1.0 + exp((-14.07+v)/6.1))
alpha_n = (alpha_A+alpha_B*v)/(alpha_C+exp((alpha_D+v)/alpha_E))
beta_n = (beta_A+beta_B*v)/(beta_C+exp((beta_D+v)/beta_E))
ks_ntau = 1/( alpha_n + beta_n)
ks_ninf = alpha_n * ks_ntau
}
UNITSON