>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> >> module's name: B >> >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> >-----------------------------------------------------------------------> >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> B: > Inactivation function (time constant method) > >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> >------------------------------->---------------------------------------> > > > > 1 > B = ssB (1) > > > > >------------------------------->---------------------------------------> 2 > ssB - B > -1 >IV< > dB/dt= ------------ (2) > > tB > >------------------------------->---------------------------------------> >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> ssB: > Steady state value for activation > >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> >----------------------->------------------------------------------------------> > 1 > 1 > > xxx.xx >h< > ssB = -------------------- (1) > > xxx.xx >s< > +- -+ p > > xxx.xx >p< > | (V-h)/s | > > > |1 + e | > > > +- -+ > > > > >----------------------->------------------------------------------------------> 2 > 1 - Bn > 0.99 >Bn< > ssB = -------------------- + Bn > 6.3 >6.3< >h< > +- -+ p > >-20 >6.3< >h< > +- -+ p > 1 >s< > | (V-h)/s | (2) > 1 >p< > |1 + e | > > +- -+ > >----------------------->------------------------------------------------------> >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> tB: > Time constant for activation > >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> >----------------------->------------------------------------------------------> > > 1 > tB = tx (1)> 3 >3< >tx< > > > .5 >3< >tx< > > >----------------------->------------------------------------------------------> > 2 > tx -tn > > .3706 >tx< > tB = -------------------- + tn (2)> > .27795 >tn< > +- -+ p > > -40.1 >h< > | (V-h)/s | > > 33.3 >s< > |1 + e | > > 1 >p< > +- -+ > > > > >----------------------->------------------------------------------------------> > 3 > tx -tn > > 1.1 >tx< > tB = ----------------------------------- + tn (3)> > 2.2 >tn< > +- -+p1 +- -+p2 > > 3.3 >h1< > | (V-h1)/s1 | | (V-h2)/s2 | > > 4.4 >s1< > |1+e | |1+e | > > 5 >p1< > +- -+ +- -+ > > 6.6 >h2< > > > 7.7 >s2< > > > 8 >p2< > > >----------------------->------------------------------------------------------> > > +-- -+ > > 4 > | 1 - rtn | > > xxx.xx >tx< > tB = tx | -------------------- + rtn | (4)> > xxx.xx >rtn< > | +- -+ p | > > xxx.xx >h< > | | (V-h)/s | | > > xxx.xx >s< > | |1 + e | | > > x >p< > | +- -+ | > > > +-- -+ > > > > >----------------------->------------------------------------------------------> > > +-- -+ > > 5 > | 1 - rtn | > > xxx.xx >tx< > tB=tx | ---------------------------------- +rtn | (5)> > xxx.xx >rtn< > | +- -+p1+- -+p2 | > > xxx.xx >h1< > | | (V-h1)/s1| | (V-h2)/s2| | > > xxx.xx >s1< > | |1+e | |1+e | | > > x >p1< > | +- -+ +- -+ | > > xxx.xx >h2< > +-- -+ > > xx.xx >s2< > > > x >p2< > > >----------------------->------------------------------------------------------> > Ligand > ------- > ssB is the steady-stae value of activation and tB is its time constant. > h's are half parameters, s's are shape parameters and p's are values of the exponents. > Bn is the minimal value of activation. > tx is the maximal value of the time constant and tn is its minimal value. > rtn = tn/tx