{load_file("nrngui.hoc")}
create soma, dend[2]
objref vc
soma { nseg=1 L=15 Ra=100
/*location 0 attached to cell 0*/
/* First segment only */
insert morphology { diam=10}
insert capacitance { cm=1}
insert pas {g_pas = 0.00005 e_pas = -65}
insert k_ion {ek = -90}
insert na_ion {ena = 60}
insert kht {gkhtbar_kht = 0.05}
insert na {gbar_na = 200}
}
dend { nseg=50 L=450 Ra=100
soma connect dend (0), soma (1)
/* First segment only */
insert pas {g_pas = 0.00005 e_pas = -65}
insert k_ion {ek = -90}
insert na_ion {ena = 60}
insert kht {gkhtbar_kht = 0.05}
insert na {gbar_na = 100}
insert capacitance { cm=2}
insert morphology { diam=3}
}
dend[1] { nseg=5 L=50 Ra=100
soma connect dend[1] (0), soma (0)
/* First segment only */
insert pas {g_pas = 0.00005 e_pas = -65}
insert k_ion {ek = -90}
insert na_ion {ena = 60}
insert kht {gkhtbar_kht = 0.05}
insert na {gbar_na = 8000}
insert capacitance { cm=1}
insert morphology { diam=1}
}
access soma
celsius=35
forall insert mhw
xpanel("measure")
xbutton("measure", "measure()")
//xbutton("10 slope_thresh and -40 vtraub","{slope_thresh_mhw=10 vtraub_hh2=-40 tstop=7}")
xbutton("20 slope_thresh","{slope_thresh_mhw=20 tstop=10}")
xbutton("graph delta t","graph_deltat()")
xbutton("graph m_inf, tau_m","m_graphs()")
xbutton("graph h_inf, tau_h","h_graphs()")
xbutton("graph n_inf, tau_n","n_graphs()")
xpanel()
proc measure() {
{mode_mhw=1 init() run() mode_mhw=2 init() run()}
for i=1,3 {
Graph[i].exec_menu("View = plot")
}
}
slope_thresh_mhw=20
dend.diam(0:1) = 3.5:1.5
dend.gbar_na(0:1) = 100:50
dend.gkhtbar_kht(0:1) = .025:.0125
soma distance() // initialize the distance function
objref delta_t
objref d_vec
objref deltatg
proc graph_deltat() {
d_vec=new Vector()
delta_t=new Vector()
deltatg=new Graph()
dend for(x,0) {
d_vec.append(distance(x))
delta_t.append(t0_mhw(x)-soma.t0_mhw(.5))
}
delta_t.line(deltatg, d_vec)
deltatg.exec_menu("View = plot")
}
objref v_vec
objref m_inf_vec, h_inf_vec, n_inf_vec
objref tau_m_vec, tau_h_vec, tau_n_vec
objref m_inf_graph, tau_m_graph, h_inf_graph, tau_h_graph, n_inf_graph, tau_n_graph
v_vec=new Vector()
for i=-120,60 {
v_vec.append(i+.5)
}
proc m_graphs() {
m_inf_vec = new Vector()
tau_m_vec = new Vector()
for i=-100,50 {
v_init=i+.5
init()
m_inf_vec.append(minf_na)
tau_m_vec.append(mtau_na)
}
m_inf_graph = new Graph()
tau_m_graph = new Graph()
m_inf_vec.line(m_inf_graph, v_vec)
tau_m_vec.line(tau_m_graph, v_vec) // make constant line visible in graph
m_inf_graph.exec_menu("View = plot")
tau_m_graph.exec_menu("View = plot")
}
proc h_graphs() {
h_inf_vec = new Vector()
tau_h_vec = new Vector()
for i=-100,50 {
v_init=i+.5
init()
h_inf_vec.append(hinf_na)
tau_h_vec.append(htau_na)
}
h_inf_graph = new Graph()
tau_h_graph = new Graph()
h_inf_vec.line(h_inf_graph, v_vec)
tau_h_vec.line(tau_h_graph, v_vec)
h_inf_graph.exec_menu("View = plot")
tau_h_graph.exec_menu("View = plot")
}
proc n_graphs() {
n_inf_vec = new Vector()
tau_n_vec = new Vector()
for i=-100,50 {
v_init=i+.5
init()
n_inf_vec.append(ninf_kht)
tau_n_vec.append(ntau_kht)
}
n_inf_graph = new Graph()
tau_n_graph = new Graph()
n_inf_vec.line(n_inf_graph, v_vec)
tau_n_vec.line(tau_n_graph, v_vec)
n_inf_graph.exec_menu("View = plot")
tau_n_graph.exec_menu("View = plot")
}