TITLE Cardiac IKx1 current
: from BEELER & REUTER, J.Physiol, 1977
NEURON {
SUFFIX IKx1
USEION k READ ek WRITE ik
RANGE gx1, ik, ix1bar, Tauact, minf, mtau
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(mM) = (milli/liter)
}
PARAMETER {
gx1=0.0008 (S/cm2) <0,1e9>
Tauact=1 (ms)
}
STATE { x1
m
}
ASSIGNED {
v (mV)
celsius (degC) : 37
ik (mA/cm2)
ix1bar (mA/cm2)
minf
mtau (ms)
ek (mV)
}
INITIAL {
rate(v*1(/mV))
m = minf
}
BREAKPOINT {
SOLVE states METHOD derivimplicit
ix1bar = gx1*(exp(0.04*(v+ 77))-1)/exp(0.04*(v + 35))
ik = ix1bar*m
}
DERIVATIVE states {
rate(v*1(/mV))
m' = (minf - m)/mtau
}
UNITSOFF
FUNCTION alp(v(mV)) {
alp = 0.0005*exp(0.083*(v + 50))/(exp(0.057*(v + 50))+1)
}
FUNCTION bet(v(mV)) {
bet = 0.0013*exp(-0.06*(v + 20))/(exp(-0.04*(v + 20)) + 1)
}
PROCEDURE rate(v)
{
LOCAL a,b
TABLE minf, mtau DEPEND celsius FROM -100 TO 100 WITH 200
a = alp(v) b = bet(v)
mtau = 1/(a + b)
minf = a/(a + b)
}
UNITSON