The folder contains the codes for reproducing the figures of the papers: Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families by M. Nicoletti et al. PloS ONE, 19(3): e0298105. https://doi.org/10.1371/journal.pone.0298105
The repository contains python codes and NEURON .mod
files for Hodgkin-Huxley models of
AVAL, AVAR, VA5, VB6, VD5, AIY, and RIM C.elegans neurons.
The .mod
files allow to model 22 ionic currents
and the intracellular calcium.
The Python files are organized for each neuron (AVAL, AVAR, AIY, RIM, VA5, VB6, VD5) as follows:
NeuronName_simulation.py
"
2.two files containing the functions for voltage and current clamp protocols entitled
"NeuronName_simulation_vclamp.py
" and "NeuronName_simulation_iclamp.py
", respectivelyTo reproduce the WT whole-cell behavior:
.mod
files in the same folder of the python codesNeuronName_simulation.py
"To simulate knock-out responses set to zero the conductance of the corresponding current.