TITLE N-type Ca current
: Taken from Retinal Ganglion Cell from Benison et al (2001), M.Migliore Nov. 2001
NEURON {
SUFFIX can
USEION ca READ eca WRITE ica
RANGE gbar
GLOBAL minf, hinf, mtau, htau
THREADSAFE minf, hinf, mtau, htau
}
PARAMETER {
gbar = 4e-2 (mho/cm2)
mafac = 0.1
mamid = -15
maslope = 5
mbfac = 0.5
mbmid = -5
mbslope = 10
hafac = 0.01
hamid = 50
haslope = 15
hbfac = 0.2
hbmid = 40
hbslope = 17
eca (mV)
v (mV)
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
}
ASSIGNED {
ica (mA/cm2)
minf hinf
mtau (ms) htau (ms)
}
STATE { m h}
BREAKPOINT {
SOLVE states METHOD cnexp
ica = gbar*m*m*h * (v - eca)
}
INITIAL {
trates(v)
m=minf
h=hinf
}
DERIVATIVE states {
trates(v)
m' = (minf-m)/mtau
h' = (hinf-h)/htau
}
PROCEDURE trates(vm) {
LOCAL a, b
:a = trap0(vm,0,0.1,10)
a = trap0(vm,mamid,mafac,maslope)
b = mbfac*exp(-(vm+mbmid)/mbslope)
minf = a/(a+b)
mtau = 1/(a+b)
a = hafac*exp(-(vm+hamid)/haslope)
b = hbfac/(1+exp(-(vm+hbmid)/hbslope))
hinf = a/(a+b)
htau = 1/(a+b)
}
FUNCTION trap0(v,th,a,q) {
if (fabs(v-th) > 1e-6) {
trap0 = a * (v - th) / (1 - exp(-(v - th)/q))
} else {
trap0 = a * q
}
}