TITLE I-h channel
: Modelled from Rugiero et al 2002, J Physiol 538:2, p447
: Written by Jordan Chambers (jordandchambers@gmail.com)
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
eih = -38 (mV)
celsius (degC)
gbar = 1e-4 (mho/cm2)
vhalf = -72 (mV)
vslope1 = 8.2 (mV)
vslope2 = 11.9 (mV)
tmc1 = 537 (ms)
tmc2 = 56 (ms)
q10 = 4.5 :guessed from other Ih studies at similar temperatures
jtmc = 1 (1)
jiih (mA/cm2)
}
NEURON {
SUFFIX ih
NONSPECIFIC_CURRENT i
GLOBAL gbar, vhalf, vslope1, vslope2, tmc1, tmc2, linf, taul
RANGE jiih
THREADSAFE linf, taul
}
STATE {
l
}
ASSIGNED {
i (mA/cm2)
linf
taul
ghd
}
INITIAL {
rate(v)
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ghd = gbar*l
i = ghd*(v-eih)
jiih = i
}
DERIVATIVE states {
rate(v)
l' = (linf - l)/taul
}
PROCEDURE rate(v (mV)) {
LOCAL a,qt
qt=q10^((celsius-34)/10)
linf = 1/(1 + exp((v - vhalf)/vslope1))
taul = jtmc*(tmc1 + (qt*tmc2/(exp((v-vhalf)/vslope2) + exp(-(v-vhalf)/vslope2))))
}