TITLE C-type potasium current
: Taken from RD Traub, J Neurophysiol 89:909-921, 2003
: Implemented by Maciej Lazarewicz 2003 (mlazarew@seas.upenn.edu)
: Adapted calcium dependence by Jordan Chambers 2012 (jordandchambers@gmail.com)
INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) }
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
(mM) = (milli/liter)
}
NEURON {
SUFFIX kca_fast
USEION k READ ek WRITE ik
USEION ca READ cai
RANGE gbar, ik, jikcaf, jk1, jk2
}
PARAMETER {
gbar = 3e-2 (mho/cm2)
v (mV)
ek (mV)
cai (mM)
cac = 6e-4 (mM)
cas = 7.5e-5 (mM)
v1 = 50
v2 = 53.5
s1 = 11
s2 = 27
eK= -95 (mV)
jikcaf (mA/cm2)
jk1
jk2
aspeed = 1
bspeed = 1
}
ASSIGNED {
ik (mA/cm2)
alpha (/ms) beta (/ms)
}
STATE {
m
}
BREAKPOINT {
SOLVE states METHOD cnexp
jk1 = 1/(1+exp(((cac-cai)/cas)))
jk2 = gbar*m*(v-ek)
ik = gbar*m*(1/(1+exp(((cac-cai)/cas))))*(v-ek)
jikcaf = ik
}
INITIAL {
settables(v)
m = alpha / ( alpha + beta )
m = 0
}
DERIVATIVE states {
settables(v)
m' = alpha * ( 1 - m ) - beta * m
}
UNITSOFF
PROCEDURE settables(v(mV)) {
TABLE alpha, beta FROM -120 TO 40 WITH 641
if( v <= -10.0 ) {
alpha = 2 / 37.95 * ( exp( ((v + v1)/s1) - ((v + v2)/s2)))
: Note that there is typo in the paper - missing minus sign in the front of 'v'
beta = 2 * exp((- v - v2)/s2) - alpha
}else{
alpha = 2 * exp(( - v - v2)/s2)
beta = 0
}
: speed-up of C kinetics here.
alpha = alpha * aspeed
beta = beta * bspeed
}
UNITSON