#==============================================================================
# Network of Dentate gyrus based on Myers and Scharfman, Hippocampus 2008
#==============================================================================
# External input --> 400 cells, PoissonGroup
# Granule cells --> 2000 cells into 100 clusters
# Basket cell (GABAergic) --> 1 per cluster (100 cells)
# Hilar mossy cells --> 80 cells
# HIPP --> 40 cells
#
#==============================================================================
# ****************************************************************************
#==============================================================================
# CONNECTIONS
# 1. input ---> granule cells : each to 20% of granule cells randomly (excitation)
# 2. input ---> HIPP : each to 20% of HIPP randomly (excitation)
# 3. mossy ---> granule cells: each to 20% randomly (excitation)
# 4. HIPP ---> granule cells: each to 20% randomly (feed forward inhibition)
# 5. granule cells ---> mossy cells: eack to 20% randomly (excitation)
# 6. basket cells <---> granule cell: one-to-all (feedback inhibition)
####################################################################################
import os
from brian import *
from brian.library.ionic_currents import *
from brian.library.IF import *
import numpy as np
import time
import math
import random as pyrandom
Trial = 1
# General Parameters
scale_fac = 4
N_input = 100 * scale_fac
N_granule = 500 * scale_fac
N_basket = 25 * scale_fac
N_mossy = 20 * scale_fac
N_hipp = 10 * scale_fac
d_input = 0.10 # active input density
reinit(states = True)
clear(erase = True, all = True)
# Active pattern of neurons
active = sorted(pyrandom.sample(xrange(N_input), int(d_input*N_input)))
np.save('active_pattern_Trial'+str(Trial)+'.npy', active)
inactive = [x for x in xrange(N_input) if x not in active]
# For second pattern with 90% overlap!
#overlap = '90'
#active_pattern = np.load('active_pattern_Trial'+str(Trial)+'.npy')
#n = int( round((1 - int(overlap)*0.01)*d_input*N_input) )
#
#removal = pyrandom.sample(active_pattern, n)
#extra = pyrandom.sample([x for x in xrange(N_input) if x not in active_pattern], n)
#
#active = [x for x in active_pattern if x not in removal]
#active += extra
#active = list(sort(active))
#inactive = [x for x in xrange(N_input) if x not in active]
print "\nBuilding the Network... "
# CONNECTIVITY PARAMETERS
# General parameters
E_nmda = 0 * mV # NMDA reversal potential
E_ampa = 0 * mV # AMPA reversal potential
E_gaba = -86 * mV # GABA reversal potential
gamma = 0.072 * mV**-1 # Mg Concentration factor
alpha_nmda = 0.5 * ms**-1 # NMDA scale factor
alpha_ampa = 1 * ms**-1 # AMPA scale factor
alpha_gaba = 1 * ms**-1 # GABA scale factor
# EC CELLS ---> GRANULE CELLS
g_ampa_eg = 0.8066 * nS
g_nmda_eg = 1.0800 * g_ampa_eg
# EC CELLS ---> HIPP CELLS
g_ampa_eh = 0.24 * nS
g_nmda_eh = 1.15 * g_ampa_eh
# SOURCE: GRANULE CELLS
# GRANULE CELLS ---> BASKET CELLS
g_ampa_gb = 0.21 * nS
g_nmda_gb = 1.50 * g_ampa_gb
# GRANULE CELLS ---> MOSSY CELLS
g_ampa_gm = 0.50 * nS
g_nmda_gm = 1.05 * g_ampa_gm
# SOURCE: MOSSY CELLS
# MOSSY CELLS ---> GRANULE CELLS
g_ampa_mg = 0.1066 * nS
g_nmda_mg = 1.0800 * g_ampa_mg
# MOSSY CELLS ---> BASKET CELLS
g_ampa_mb = 0.35 * nS
g_nmda_mb = 1.10 * g_ampa_mb
# SOURCE: BASKET CELLS
# BASKET CELLS ---> GRANULE CELLS
g_gaba_bg = 14.0 * nS
# SOURCE: HIPP CELLS
# HIPP CELLS ---> GRANULE CELLS
g_gaba_hg = 0.12 * nS
#=======================================================================================================================
#=======================================================================================================================
# INPUT CELLS (ENTORHINAL CORTEX)
from poisson_input import *
rate = 40*Hz
simtime = 500*ms
t1 = 300 * ms
t2 = 10 * ms
spiketimes = poisson_input(active, N_input, rate, simtime, t1, t2)
Input_ec = SpikeGeneratorGroup(N_input, spiketimes)
#=======================================================================================================================
# GRANULE CELLS
# Parameters
gl = 0.00003 * siemens/(cm**2) # leakage conductance
gl_dend = 0.00001 * siemens/(cm**2) # leakage conductance
El_soma = -87.0 * mV # reversal-resting potential
El_dend = -82.0 * mV # reversal-resting potential
Cm = 1.0 * uF/(cm**2) # membrane capacitance
Cm_dend = 2.5 * uF/(cm**2) # membrane capacitance
v_th = -56.0 * mV # threshold potential
v_reset = -74.0 * mV # reset potential
# Morphology
# Soma
length_soma = 18.0 * um
diam_soma = 12.0 * um
area_soma = math.pi * diam_soma * length_soma
# Dendrites
Nseg = 15 # Number of dendritic compartments
Nbranch = 3 # Number of main branches
Ntips = 6 # Number of distal dendritic compartments
distal_l = 83.0 * um
medial_l = 83.0 * um
proximal_l = 83.0 * um
length_dend = [distal_l, distal_l, medial_l, medial_l, proximal_l]
length_dend *= Nbranch
distal_d = 0.80 * um
medial_d = 0.90 * um
proximal_d = 1.00 * um
diam_dend = [distal_d, distal_d, medial_d, medial_d, proximal_d]
diam_dend *= Nbranch
area_dend = [math.pi*x*y for x,y in zip(length_dend, diam_dend)]
# AMPA/NMDA/GABA Kinetics
t_nmda_decay_g = 50.0 * ms # NMDA decay time constant
t_nmda_rise_g = 0.33 * ms # NMDA rise time constant
t_ampa_decay_g = 2.5 * ms # AMPA decay time constant
t_ampa_rise_g = 0.1 * ms # AMPA rise time constant
t_gaba_decay_g = 6.8 * ms # GABA decay time constant
t_gaba_rise_g = 0.9 * ms # GABA rise time constant
# AMPA/NMDA/GABA Model Parameters
gamma_g = 0.04 * mV**-1 # the steepness of Mg sensitivity of Mg unblock
Mg = 2.0 # [mM]--mili Molar - the extracellular Magnesium concentration
eta = 0.2 # [mM**-1] -1- mili Molar **(-1) - Magnesium sensitivity of unblock
alpha_nmda_g = 2.0 * ms**-1
alpha_ampa = 1.0 * ms**-1
alpha_gaba = 1.0 * ms**-1
# Axial resistances
Ri = 210.0 * ohm * cm
ra0 = Ri * 4 / (pi * distal_d ** 2)
ra1 = Ri * 4 / (pi * medial_d ** 2)
ra2 = Ri * 4 / (pi * proximal_d ** 2)
Ra_0 = ra0 * distal_l
Ra_1 = ra1 * medial_l
Ra_2 = ra2 * proximal_l
# NOISE
g_ampa_gn = 0.008 * nS
g_nmda_gn = 0.008 * nS
# AHP patrameters
tau_ahp = 45*ms
g_ahp = 2*nS
# Synaptic current equations @ SOMA
eq_soma = Equations('''
I_synS = I_gaba_bg - I_inj + I_Sahp : amp
I_Sahp : amp
dI_Sahp/dt = (g_ahp*(vm-El_soma)-I_Sahp)/tau_ahp : amp
I_gaba_bg = g_gaba_bg*(vm - E_gaba)*s_gaba_bg : amp
s_gaba_bg : 1
I_inj : amp
''')
# Synaptic current equations
eq_dend = Equations('''
I_synD = I_nmda_eg + I_ampa_eg + I_nmda_mg + I_ampa_mg + I_gaba_hg + I_nmda_gn + I_ampa_gn : amp
I_nmda_eg = g_nmda_eg*(vm - E_nmda)*s_nmda_eg*(1.0/(1 + eta*Mg*exp(-gamma_g*vm))) : amp
I_ampa_eg = g_ampa_eg*(vm - E_ampa)*s_ampa_eg : amp
s_nmda_eg : 1
s_ampa_eg : 1
I_nmda_mg = g_nmda_mg*(vm - E_nmda)*s_nmda_mg*(1.0/(1 + eta*Mg*exp(-gamma_g*vm))) : amp
I_ampa_mg = g_ampa_mg*(vm - E_ampa)*s_ampa_mg : amp
s_nmda_mg : 1
s_ampa_mg : 1
I_nmda_gn = g_nmda_gn*(vm - E_nmda)*s_nmda_gn*(1.0/(1 + eta*Mg*exp(-gamma_g*vm))) : amp
I_ampa_gn = g_ampa_gn*(vm - E_ampa)*s_ampa_gn : amp
s_nmda_gn : 1
s_ampa_gn : 1
I_gaba_hg = g_gaba_hg*(vm - E_gaba)*s_gaba_hg : amp
s_gaba_hg : 1
''')
# Soma equation
eqs_soma = MembraneEquation(Cm * area_soma)
eqs_soma += leak_current(gl * area_soma, El_soma)
eqs_soma += IonicCurrent('I = I_synS : amp')
eqs_soma += eq_soma
# Dendrite equations
eqs_dendrite = {}
# area_dend *= 3
for seg in xrange(Nseg):
eqs_dendrite[seg] = MembraneEquation(Cm_dend * area_dend[seg])
eqs_dendrite[seg] += leak_current(gl_dend * area_dend[seg], El_dend, current_name = 'Il')
eqs_dendrite[seg] += IonicCurrent('I = I_synD: amp') + eq_dend
granule_eqs = Compartments({'soma' : eqs_soma,
'dend001': eqs_dendrite[0],
'dend002': eqs_dendrite[1],
'dend011': eqs_dendrite[2],
'dend012': eqs_dendrite[3],
'dend02': eqs_dendrite[4],
'dend101': eqs_dendrite[5],
'dend102': eqs_dendrite[6],
'dend111': eqs_dendrite[7],
'dend112': eqs_dendrite[8],
'dend12': eqs_dendrite[9],
'dend201': eqs_dendrite[10],
'dend202': eqs_dendrite[11],
'dend211': eqs_dendrite[12],
'dend212': eqs_dendrite[13],
'dend22': eqs_dendrite[14]})
granule_eqs.connect('dend001', 'dend011', Ra_0)
granule_eqs.connect('dend002', 'dend012', Ra_0)
granule_eqs.connect('dend011', 'dend02', Ra_1)
granule_eqs.connect('dend012', 'dend02', Ra_1)
granule_eqs.connect('dend02', 'soma', Ra_2)
granule_eqs.connect('dend101', 'dend111', Ra_0)
granule_eqs.connect('dend102', 'dend112', Ra_0)
granule_eqs.connect('dend111', 'dend12', Ra_1)
granule_eqs.connect('dend112', 'dend12', Ra_1)
granule_eqs.connect('dend12', 'soma', Ra_2)
granule_eqs.connect('dend201', 'dend211', Ra_0)
granule_eqs.connect('dend202', 'dend212', Ra_0)
granule_eqs.connect('dend211', 'dend22', Ra_1)
granule_eqs.connect('dend212', 'dend22', Ra_1)
granule_eqs.connect('dend22', 'soma', Ra_2)
granule = NeuronGroup(N_granule, model = granule_eqs, threshold = 'vm_soma > v_th',
reset = 'vm_soma = v_reset; I_Sahp_soma += 0.0450*nA',
refractory = 20 * ms, compile = True, freeze = True)
# Initialization of membrane potential
granule.vm_soma = El_soma
# 1st branch
granule.vm_dend001 = El_dend
granule.vm_dend002 = El_dend
granule.vm_dend011 = El_dend
granule.vm_dend012 = El_dend
granule.vm_dend02 = El_dend
# 2nd branch
granule.vm_dend101 = El_dend
granule.vm_dend102 = El_dend
granule.vm_dend111 = El_dend
granule.vm_dend112 = El_dend
granule.vm_dend12 = El_dend
# 3rd branch
granule.vm_dend201 = El_dend
granule.vm_dend202 = El_dend
granule.vm_dend211 = El_dend
granule.vm_dend212 = El_dend
granule.vm_dend22 = El_dend
#Clustering of granule cells
counter = 20
N_cl = len(granule)/counter
granule_cl = {}
for gran in xrange(N_cl):
granule_cl[gran] = granule.subgroup(counter)
#=======================================================================================================================
#=======================================================================================================================
# BASKET CELLS
# Parameters
gl_b = 18.054 * nS # leakage conductance
El_b = -52 * mV # reversal-resting potential
Cm_b = 0.1793 * nF # membrane capacitance
v_th_b = -39 * mV # threshold potential
v_reset_b = -45 * mV # reset potential
DeltaT_b = 2 * mV # slope factor
# Synaptic Parameters
gamma = 0.072 * mV**-1 # Mg Concentration factor
alpha_nmda = 0.5 * ms**-1 # NMDA scale factor
alpha_ampa = 1 * ms**-1 # AMPA scale factor
alpha_gaba = 1 * ms**-1 # GABA scale factor
#AMPA/NMDA Kinetics
t_nmda_decay_b = 130.0 * ms # NMDA decay time constant
t_nmda_rise_b = 10.0 * ms # NMDA rise time constant
t_ampa_decay_b = 4.2 * ms # AMPA decay time constant
t_ampa_rise_b = 1.2 * ms # AMPA rise time constant
# NOISE
g_nmda_bn = 2.5 * nS # NMDA maximum conductance
g_ampa_bn = 3.5 * nS # AMPA maximum conductance
t_nmda_decay_bn = 130 * ms # NMDA decay time constant
t_nmda_rise_bn = 10 * ms # NMDA rise time constant
t_ampa_decay_bn = 4.2 * ms # AMPA decay time constant
t_ampa_rise_bn = 1.2 * ms # AMPA rise time constant
# Synaptic current equations
eq_soma_b = Equations('''
I_syn_b = I_nmda_gb + I_ampa_gb + I_nmda_mb + I_ampa_mb + I_nmda_bn + I_ampa_bn : amp
I_nmda_gb = g_nmda_gb*(vm - E_nmda)*s_nmda_gb*(1.0/(1 + exp(-gamma*vm)*(1.0/3.57))) : amp
I_ampa_gb = g_ampa_gb*(vm - E_ampa)*s_ampa_gb : amp
s_nmda_gb : 1
s_ampa_gb : 1
I_nmda_mb = g_nmda_mb*(vm - E_nmda)*s_nmda_mb*(1.0/(1 + exp(-gamma*vm)*(1.0/3.57))) : amp
I_ampa_mb = g_ampa_mb*(vm - E_ampa)*s_ampa_mb : amp
s_nmda_mb : 1
s_ampa_mb : 1
I_nmda_bn = g_nmda_bn*(vm - E_nmda)*s_nmda_bn*(1.0/(1 + exp(-gamma*vm)*(1.0/3.57))) : amp
I_ampa_bn = g_ampa_bn*(vm - E_ampa)*s_ampa_bn : amp
s_nmda_bn : 1
s_ampa_bn : 1
''')
# Brette-Gerstner
basket_eqs = Brette_Gerstner(Cm_b, gl_b, El_b, v_th_b, DeltaT_b, tauw = 100 * ms, a = .1 * nS)
basket_eqs += IonicCurrent('I = I_syn_b : amp')
basket_eqs += eq_soma_b
basket = NeuronGroup(N_basket, model = basket_eqs, threshold = 'vm > v_th_b',
reset = AdaptiveReset(Vr=v_reset_b, b = 0.0205*nA),
refractory = 2 * ms, compile = True)
# Initialization of membrane potential
basket.vm = El_b
basket_cl = {}
for bb in xrange(N_cl):
basket_cl[bb] = basket.subgroup(1)
#=======================================================================================================================
#=======================================================================================================================
# MOSSY CELLS
# Parameters
gl_m = 4.53 * nS # leakage conductance
El_m = -64 * mV # reversal-resting potential
Cm_m = 0.2521 * nfarad # membrane capacitance
v_th_m = -42 * mV # threshold potential
v_reset_m = -49 * mV # reset potential
DeltaT_m = 2 * mV # slope factor
# Synaptic Parameters
gamma = 0.072 * mV**-1 # Mg Concentration factor
alpha_nmda = 0.5 * ms**-1 # NMDA scale factor
alpha_ampa = 1 * ms**-1 # AMPA scale factor
alpha_gaba = 1 * ms**-1 # GABA scale factor
#AMPA/NMDA Kinetics
t_nmda_decay_m = 100 * ms # NMDA decay time constant
t_nmda_rise_m = 4 * ms # NMDA rise time constant
t_ampa_decay_m = 6.2 * ms # AMPA decay time constant
t_ampa_rise_m = 0.5 * ms # AMPA rise time constant
# Noise model Parameters
g_nmda_mn = 4.465 * nS # NMDA maximum conductance
g_ampa_mn = 4.7 * nS # AMPA maximum conductance
t_nmda_decay_mn = 100 * ms # NMDA decay time constant
t_nmda_rise_mn = 4 * ms # NMDA rise time constant
t_ampa_decay_mn = 6.2 * ms # AMPA decay time constant
t_ampa_rise_mn = 0.5 * ms # AMPA rise time constant
# Synaptic current equations
eq_soma_m = Equations('''
I_syn_m = I_ampa_gm + I_nmda_gm + I_ampa_mn + I_nmda_mn : amp
I_nmda_gm = g_nmda_gm*(vm - E_nmda)*s_nmda_gm*(1.0/(1 + exp(-gamma*vm)*(1.0/3.57))) : amp
I_ampa_gm = g_ampa_gm*(vm - E_ampa)*s_ampa_gm : amp
s_nmda_gm : 1
s_ampa_gm : 1
I_nmda_mn = g_nmda_mn*(vm - E_nmda)*s_nmda_mn*(1.0/(1 + exp(-gamma*vm)*(1.0/3.57))) : amp
I_ampa_mn = g_ampa_mn*(vm - E_ampa)*s_ampa_mn : amp
s_nmda_mn : 1
s_ampa_mn : 1
''')
# Brette-Gerstner
mossy_eqs = Brette_Gerstner(Cm_m, gl_m, El_m, v_th_m, DeltaT_m, tauw = 180 * ms, a = 1 * nS)
mossy_eqs += IonicCurrent('I = I_syn_m : amp')
mossy_eqs += eq_soma_m
mossy = NeuronGroup(N_mossy, model = mossy_eqs, threshold = 'vm > v_th_m',
reset = AdaptiveReset(Vr=v_reset_m, b = 0.0829*nA),
refractory = 2 * ms, compile = True)
# Initialization of membrane potential
mossy.vm = El_m
#=======================================================================================================================
#=======================================================================================================================
# HIPP CELLS
# Parameters
gl_h = 1.930 * nS # leakage conductance
El_h = -59 * mV # reversal-resting potential
Cm_h = 0.0584 * nF # membrane capacitance
v_th_h = -50 * mV # threshold potential
v_reset_h = -56 * mV # reset potential
DeltaT_h = 2 * mV # slope factor
# Synaptic Parameters
gamma = 0.072 * mV**-1 # Mg Concentration factor
alpha_nmda = 0.5 * ms**-1 # NMDA scale factor
alpha_ampa = 1 * ms**-1 # AMPA scale factor
alpha_gaba = 1 * ms**-1 # GABA scale factor
#AMPA/NMDA Kinetics
t_nmda_decay_h = 110 * ms # NMDA decay time constant
t_nmda_rise_h = 4.8 * ms # NMDA rise time constant
t_ampa_decay_h = 11.0 * ms # AMPA decay time constant
t_ampa_rise_h = 2.0 * ms # AMPA rise time constant
# NOISE
g_nmda_hn = 0.2 * nS # NMDA maximum conductance
g_ampa_hn = 0.2 * nS # AMPA maximum conductance
t_nmda_decay_hn = 100 * ms # NMDA decay time constant
t_nmda_rise_hn = 5.0 * ms # NMDA rise time constant
t_ampa_decay_hn = 11.0 * ms # AMPA decay time constant
t_ampa_rise_hn = 2.0 * ms # AMPA rise time constant
# Synaptic current equations
eq_soma_h = Equations('''
I_syn_h = I_nmda_eh + I_ampa_eh + I_nmda_hn + I_ampa_hn : amp
I_nmda_eh = g_nmda_eh*(vm - E_nmda)*s_nmda_eh*1./(1 + exp(-gamma*vm)/3.57) : amp
I_ampa_eh = g_ampa_eh*(vm - E_ampa)*s_ampa_eh : amp
s_nmda_eh : 1
s_ampa_eh : 1
I_nmda_hn = g_nmda_hn*(vm - E_nmda)*s_nmda_hn*(1.0/(1 + exp(-gamma*vm)*(1.0/3.57))) : amp
I_ampa_hn = g_ampa_hn*(vm - E_ampa)*s_ampa_hn : amp
s_nmda_hn : 1
s_ampa_hn : 1
''')
# Brette-Gerstner
hipp_eqs = Brette_Gerstner(Cm_h, gl_h, El_h, v_th_h, DeltaT_h, tauw = 93 * ms, a = .82 * nS)
hipp_eqs += IonicCurrent('I = I_syn_h : amp')
hipp_eqs += eq_soma_h
hipp = NeuronGroup(N_hipp, model = hipp_eqs, threshold = 'vm > v_th_h',
reset = AdaptiveReset(Vr=v_reset_h, b = 0.015*nA),
refractory = 3 * ms, compile = True)
# Initialization of membrane potential
hipp.vm = El_h
#=======================================================================================================================
#=======================================================================================================================
# *************************************** C O N N E C T I O N S ********************************************
#=======================================================================================================================
os.chdir('ConnectivityMatrices_6dendrites/')
# EC CELLS ----> GRANULE CELLS
a = 1.0
# Synapses at 1st dendrite
nmda_eqs_eg1 = '''
dj_eg1/dt = -j_eg1 / t_nmda_decay_g + alpha_nmda_g * x_eg1 * (1 - j_eg1) : 1
dx_eg1/dt = -x_eg1 / t_nmda_rise_g : 1
wNMDA_eg1 : 1
'''
synNMDA_eg1 = Synapses(Input_ec, granule, model = nmda_eqs_eg1, pre = 'x_eg1 += wNMDA_eg1', implicit=True, freeze=True)
granule.s_nmda_eg_dend001 = synNMDA_eg1.j_eg1
synNMDA_eg1.load_connectivity('syn_eg1.txt')
synNMDA_eg1.wNMDA_eg1[:, :] = 1.0*a
synNMDA_eg1.delay[:, :] = 3 * ms
ampa_eqs_eg1 = '''
dy_eg1/dt = -y_eg1 / t_ampa_decay_g + alpha_ampa * h_eg1 * (1 - y_eg1) : 1
dh_eg1/dt = -h_eg1 / t_ampa_rise_g : 1
wAMPA_eg1 : 1
'''
synAMPA_eg1 = Synapses(Input_ec, granule, model = ampa_eqs_eg1, pre = 'h_eg1 += wAMPA_eg1', implicit=True, freeze=True)
granule.s_ampa_eg_dend001 = synAMPA_eg1.y_eg1
synAMPA_eg1.load_connectivity('syn_eg1.txt')
synAMPA_eg1.wAMPA_eg1[:, :] = 1.0*a
synAMPA_eg1.delay[:, :] = 3 * ms
# Synapses at 2nd dendrite
nmda_eqs_eg2 = '''
dj_eg2/dt = -j_eg2 / t_nmda_decay_g + alpha_nmda_g * x_eg2 * (1 - j_eg2) : 1
dx_eg2/dt = -x_eg2 / t_nmda_rise_g : 1
wNMDA_eg2 : 1
'''
synNMDA_eg2 = Synapses(Input_ec, granule, model = nmda_eqs_eg2, pre = 'x_eg2 += wNMDA_eg2', implicit=True, freeze=True)
granule.s_nmda_eg_dend002 = synNMDA_eg2.j_eg2
synNMDA_eg2.load_connectivity('syn_eg2.txt')
synNMDA_eg2.wNMDA_eg2[:, :] = 1.0*a
synNMDA_eg2.delay[:, :] = 3 * ms
ampa_eqs_eg2 = '''
dy_eg2/dt = -y_eg2 / t_ampa_decay_g + alpha_ampa * h_eg2 * (1 - y_eg2) : 1
dh_eg2/dt = -h_eg2 / t_ampa_rise_g : 1
wAMPA_eg2 : 1
'''
synAMPA_eg2 = Synapses(Input_ec, granule, model = ampa_eqs_eg2, pre = 'h_eg2 += wAMPA_eg2', implicit=True, freeze=True)
granule.s_ampa_eg_dend002 = synAMPA_eg2.y_eg2
synAMPA_eg2.load_connectivity('syn_eg2.txt')
synAMPA_eg2.wAMPA_eg2[:, :] = 1.0*a
synAMPA_eg2.delay[:, :] = 3 * ms
# Synapses at 3rd dendrite
nmda_eqs_eg3 = '''
dj_eg3/dt = -j_eg3 / t_nmda_decay_g + alpha_nmda_g * x_eg3 * (1 - j_eg3) : 1
dx_eg3/dt = -x_eg3 / t_nmda_rise_g : 1
wNMDA_eg3 : 1
'''
synNMDA_eg3 = Synapses(Input_ec, granule, model = nmda_eqs_eg3, pre = 'x_eg3 += wNMDA_eg3', implicit=True, freeze=True)
granule.s_nmda_eg_dend101 = synNMDA_eg3.j_eg3
synNMDA_eg3.load_connectivity('syn_eg3.txt')
synNMDA_eg3.wNMDA_eg3[:, :] = 1.0*a
synNMDA_eg3.delay[:, :] = 3 * ms
ampa_eqs_eg3 = '''
dy_eg3/dt = -y_eg3 / t_ampa_decay_g + alpha_ampa * h_eg3 * (1 - y_eg3) : 1
dh_eg3/dt = -h_eg3 / t_ampa_rise_g : 1
wAMPA_eg3 : 1
'''
synAMPA_eg3 = Synapses(Input_ec, granule, model = ampa_eqs_eg3, pre = 'h_eg3 += wAMPA_eg3', implicit=True, freeze=True)
granule.s_ampa_eg_dend101 = synAMPA_eg3.y_eg3
synAMPA_eg3.load_connectivity('syn_eg3.txt')
synAMPA_eg3.wAMPA_eg3[:, :] = 1.0*a
synAMPA_eg3.delay[:, :] = 3 * ms
# Synapses at 4th dendrite
nmda_eqs_eg4 = '''
dj_eg4/dt = -j_eg4 / t_nmda_decay_g + alpha_nmda_g * x_eg4 * (1 - j_eg4) : 1
dx_eg4/dt = -x_eg4 / t_nmda_rise_g : 1
wNMDA_eg4 : 1
'''
synNMDA_eg4 = Synapses(Input_ec, granule, model = nmda_eqs_eg4, pre = 'x_eg4 += wNMDA_eg4', implicit=True, freeze=True)
granule.s_nmda_eg_dend102 = synNMDA_eg4.j_eg4
synNMDA_eg4.load_connectivity('syn_eg4.txt')
synNMDA_eg4.wNMDA_eg4[:, :] = 1.0*a
synNMDA_eg4.delay[:, :] = 3 * ms
ampa_eqs_eg4 = '''
dy_eg4/dt = -y_eg4 / t_ampa_decay_g + alpha_ampa * h_eg4 * (1 - y_eg4) : 1
dh_eg4/dt = -h_eg4 / t_ampa_rise_g : 1
wAMPA_eg4 : 1
'''
synAMPA_eg4 = Synapses(Input_ec, granule, model = ampa_eqs_eg4, pre = 'h_eg4 += wAMPA_eg4', implicit=True, freeze=True)
granule.s_ampa_eg_dend102 = synAMPA_eg4.y_eg4
synAMPA_eg4.load_connectivity('syn_eg4.txt')
synAMPA_eg4.wAMPA_eg4[:, :] = 1.0*a
synAMPA_eg4.delay[:, :] = 3 * ms
# Synapses at 5th dendrite
nmda_eqs_eg5 = '''
dj_eg5/dt = -j_eg5 / t_nmda_decay_g + alpha_nmda_g * x_eg5 * (1 - j_eg5) : 1
dx_eg5/dt = -x_eg5 / t_nmda_rise_g : 1
wNMDA_eg5 : 1
'''
synNMDA_eg5 = Synapses(Input_ec, granule, model = nmda_eqs_eg5, pre = 'x_eg5 += wNMDA_eg5', implicit=True, freeze=True)
granule.s_nmda_eg_dend201 = synNMDA_eg5.j_eg5
synNMDA_eg5.load_connectivity('syn_eg5.txt')
synNMDA_eg5.wNMDA_eg5[:, :] = 1.0*a
synNMDA_eg5.delay[:, :] = 3 * ms
ampa_eqs_eg5 = '''
dy_eg5/dt = -y_eg5 / t_ampa_decay_g + alpha_ampa * h_eg5 * (1 - y_eg5) : 1
dh_eg5/dt = -h_eg5 / t_ampa_rise_g : 1
wAMPA_eg5 : 1
'''
synAMPA_eg5 = Synapses(Input_ec, granule, model = ampa_eqs_eg5, pre = 'h_eg5 += wAMPA_eg5', implicit=True, freeze=True)
granule.s_ampa_eg_dend201 = synAMPA_eg5.y_eg5
synAMPA_eg5.load_connectivity('syn_eg5.txt')
synAMPA_eg5.wAMPA_eg5[:, :] = 1.0*a
synAMPA_eg5.delay[:, :] = 3 * ms
# Synapses at 6th dendrite
nmda_eqs_eg6 = '''
dj_eg6/dt = -j_eg6 / t_nmda_decay_g + alpha_nmda_g * x_eg6 * (1 - j_eg6) : 1
dx_eg6/dt = -x_eg6 / t_nmda_rise_g : 1
wNMDA_eg6 : 1
'''
synNMDA_eg6 = Synapses(Input_ec, granule, model = nmda_eqs_eg6, pre = 'x_eg6 += wNMDA_eg6', implicit=True, freeze=True)
granule.s_nmda_eg_dend202 = synNMDA_eg6.j_eg6
synNMDA_eg6.load_connectivity('syn_eg6.txt')
synNMDA_eg6.wNMDA_eg6[:, :] = 1.0*a
synNMDA_eg6.delay[:, :] = 3 * ms
ampa_eqs_eg6 = '''
dy_eg6/dt = -y_eg6 / t_ampa_decay_g + alpha_ampa * h_eg6 * (1 - y_eg6) : 1
dh_eg6/dt = -h_eg6 / t_ampa_rise_g : 1
wAMPA_eg6 : 1
'''
synAMPA_eg6 = Synapses(Input_ec, granule, model = ampa_eqs_eg6, pre = 'h_eg6 += wAMPA_eg6', implicit=True, freeze=True)
granule.s_ampa_eg_dend202 = synAMPA_eg6.y_eg6
synAMPA_eg6.load_connectivity('syn_eg6.txt')
synAMPA_eg6.wAMPA_eg6[:, :] = 1.0*a
synAMPA_eg6.delay[:, :] = 3 * ms
# EC CELLS ---> HIPP CELLS
# The NMDA/AMPA synapses @ hipp cell
nmda_eqs_eh = '''
dj_eh/dt = -j_eh / t_nmda_decay_h + alpha_nmda * x_eh * (1 - j_eh) : 1
dx_eh/dt = -x_eh / t_nmda_rise_h : 1
wNMDA_eh : 1
'''
synNMDA_eh = Synapses(Input_ec, hipp, model = nmda_eqs_eh, pre = 'x_eh += wNMDA_eh', implicit=True, freeze=True)
hipp.s_nmda_eh = synNMDA_eh.j_eh
synNMDA_eh.load_connectivity('syn_eh.txt')
synNMDA_eh.wNMDA_eh[:, :] = 1.0
synNMDA_eh.delay[:, :] = 3.0 * ms
ampa_eqs_eh = '''
dy_eh/dt = -y_eh / t_ampa_decay_h + h_eh*alpha_ampa*(1 - y_eh) : 1
dh_eh/dt = -h_eh / t_ampa_rise_h : 1
wAMPA_eh : 1
'''
synAMPA_eh = Synapses(Input_ec, hipp, model = ampa_eqs_eh, pre = 'h_eh += wAMPA_eh', implicit=True, freeze=True)
hipp.s_ampa_eh = synAMPA_eh.y_eh
synAMPA_eh.load_connectivity('syn_eh.txt')
synAMPA_eh.wAMPA_eh[:, :] = 1.0
synAMPA_eh.delay[:, :] = 3.0 * ms
# GRANULE CELLS ---> MOSSY CELLS
# The NMDA/AMPA synapses @ mossy cell
nmda_eqs_gm = '''
dj_gm/dt = -j_gm / t_nmda_decay_m + alpha_nmda * x_gm * (1 - j_gm) : 1
dx_gm/dt = -x_gm / t_nmda_rise_m : 1
wNMDA_gm : 1
'''
synNMDA_gm = Synapses(granule, mossy, model = nmda_eqs_gm, pre = 'x_gm += wNMDA_gm', implicit=True, freeze=True)
mossy.s_nmda_gm = synNMDA_gm.j_gm
synNMDA_gm.load_connectivity('syn_gm.txt')
synNMDA_gm.wNMDA_gm[:, :] = 1.0
synNMDA_gm.delay[:, :] = 1.5 * ms
ampa_eqs_gm = '''
dy_gm/dt = -y_gm / t_ampa_decay_m + h_gm*alpha_ampa*(1 - y_gm) : 1
dh_gm/dt = -h_gm / t_ampa_rise_m : 1
wAMPA_gm : 1
'''
synAMPA_gm = Synapses(granule, mossy, model = ampa_eqs_gm, pre = 'h_gm += wAMPA_gm', implicit=True, freeze=True)
mossy.s_ampa_gm = synAMPA_gm.y_gm
synAMPA_gm.load_connectivity('syn_gm.txt')
synAMPA_gm.wAMPA_gm[:, :] = 1.0
synAMPA_gm.delay[:, :] = 1.5 * ms
# GRANULE CELLS ---> BASKET CELLS
# The NMDA/AMPA synapses @ basket cell
synNMDA_gb = {}
synAMPA_gb = {}
for gtob in xrange(N_cl):
nmda_eqs_gb = '''
dj_gb/dt = -j_gb / t_nmda_decay_b + alpha_nmda * x_gb * (1 - j_gb) : 1
dx_gb/dt = -x_gb / t_nmda_rise_b : 1
wNMDA_gb : 1
'''
synNMDA_gb[gtob] = Synapses(granule_cl[gtob], basket_cl[gtob], model = nmda_eqs_gb, pre = 'x_gb += wNMDA_gb', implicit=True, freeze=True)
basket_cl[gtob].s_nmda_gb = synNMDA_gb[gtob].j_gb
synNMDA_gb[gtob].connect_random(granule_cl[gtob], basket_cl[gtob], sparseness = 1.0)
synNMDA_gb[gtob].wNMDA_gb[:, :] = 1.0
synNMDA_gb[gtob].delay[:, :] = 0.8 * ms
ampa_eqs_gb = '''
dy_gb/dt = -y_gb / t_ampa_decay_b + h_gb*alpha_ampa*(1 - y_gb) : 1
dh_gb/dt = -h_gb / t_ampa_rise_b : 1
wAMPA_gb : 1
'''
synAMPA_gb[gtob] = Synapses(granule_cl[gtob], basket_cl[gtob], model = ampa_eqs_gb, pre = 'h_gb += wAMPA_gb', implicit=True, freeze=True)
basket_cl[gtob].s_ampa_gb = synAMPA_gb[gtob].y_gb
synAMPA_gb[gtob].connect_random(granule_cl[gtob], basket_cl[gtob], sparseness = 1.0)
synAMPA_gb[gtob].wAMPA_gb[:, :] = 1.0
synAMPA_gb[gtob].delay[:, :] = 0.8 * ms
# MOSSY CELLS ---> GRANULE CELLS
# The NMDA/AMPA synapses @ granule proximal dendrite (dendrite 2)
# 1st branch
nmda_eqs_mg1 = '''
dj_mg1/dt = -j_mg1 / t_nmda_decay_g + alpha_nmda_g * x_mg1 * (1 - j_mg1) : 1
dx_mg1/dt = -x_mg1 / t_nmda_rise_g : 1
wNMDA_mg1 : 1
'''
synNMDA_mg1 = Synapses(mossy, granule, model = nmda_eqs_mg1, pre = 'x_mg1 += wNMDA_mg1', implicit=True, freeze=True)
granule.s_nmda_mg_dend02 = synNMDA_mg1.j_mg1
synNMDA_mg1.load_connectivity('syn_mg1.txt')
synNMDA_mg1.wNMDA_mg1[:, :] = 1.0
synNMDA_mg1.delay[:, :] = 3.0 * ms
ampa_eqs_mg1 = '''
dy_mg1/dt = -y_mg1 / t_ampa_decay_g + h_mg1*alpha_ampa*(1 - y_mg1) : 1
dh_mg1/dt = -h_mg1 / t_ampa_rise_g : 1
wAMPA_mg1 : 1
'''
synAMPA_mg1 = Synapses(mossy, granule, model = ampa_eqs_mg1, pre = 'h_mg1 += wAMPA_mg1', implicit=True, freeze=True)
granule.s_ampa_mg_dend02 = synAMPA_mg1.y_mg1
synAMPA_mg1.load_connectivity('syn_mg1.txt')
synAMPA_mg1.wAMPA_mg1[:, :] = 1.0
synAMPA_mg1.delay[:, :] = 3.0 * ms
# 2nd branch
nmda_eqs_mg2 = '''
dj_mg2/dt = -j_mg2 / t_nmda_decay_g + alpha_nmda_g * x_mg2 * (1 - j_mg2) : 1
dx_mg2/dt = -x_mg2 / t_nmda_rise_g : 1
wNMDA_mg2 : 1
'''
synNMDA_mg2 = Synapses(mossy, granule, model = nmda_eqs_mg2, pre = 'x_mg2 += wNMDA_mg2', implicit=True, freeze=True)
granule.s_nmda_mg_dend12 = synNMDA_mg2.j_mg2
synNMDA_mg2.load_connectivity('syn_mg2.txt')
synNMDA_mg2.wNMDA_mg2[:, :] = 1.0
synNMDA_mg2.delay[:, :] = 3.0 * ms
ampa_eqs_mg2 = '''
dy_mg2/dt = -y_mg2 / t_ampa_decay_g + h_mg2*alpha_ampa*(1 - y_mg2) : 1
dh_mg2/dt = -h_mg2 / t_ampa_rise_g : 1
wAMPA_mg2 : 1
'''
synAMPA_mg2 = Synapses(mossy, granule, model = ampa_eqs_mg2, pre = 'h_mg2 += wAMPA_mg2', implicit=True, freeze=True)
granule.s_ampa_mg_dend12 = synAMPA_mg2.y_mg2
synAMPA_mg2.load_connectivity('syn_mg2.txt')
synAMPA_mg2.wAMPA_mg2[:, :] = 1.0
synAMPA_mg2.delay[:, :] = 3.0 * ms
# 3rd branch
nmda_eqs_mg3 = '''
dj_mg3/dt = -j_mg3 / t_nmda_decay_g + alpha_nmda_g * x_mg3 * (1 - j_mg3) : 1
dx_mg3/dt = -x_mg3 / t_nmda_rise_g : 1
wNMDA_mg3 : 1
'''
synNMDA_mg3 = Synapses(mossy, granule, model = nmda_eqs_mg3, pre = 'x_mg3 += wNMDA_mg3', implicit=True, freeze=True)
granule.s_nmda_mg_dend22 = synNMDA_mg3.j_mg3
synNMDA_mg3.load_connectivity('syn_mg3.txt')
synNMDA_mg3.wNMDA_mg3[:, :] = 1.0
synNMDA_mg3.delay[:, :] = 3.0 * ms
ampa_eqs_mg3 = '''
dy_mg3/dt = -y_mg3 / t_ampa_decay_g + h_mg3*alpha_ampa*(1 - y_mg3) : 1
dh_mg3/dt = -h_mg3 / t_ampa_rise_g : 1
wAMPA_mg3 : 1
'''
synAMPA_mg3 = Synapses(mossy, granule, model = ampa_eqs_mg3, pre = 'h_mg3 += wAMPA_mg3', implicit=True, freeze=True)
granule.s_ampa_mg_dend22 = synAMPA_mg3.y_mg3
synAMPA_mg3.load_connectivity('syn_mg3.txt')
synAMPA_mg3.wAMPA_mg3[:, :] = 1.0
synAMPA_mg3.delay[:, :] = 3.0 * ms
# MOSSY CELL ---> BASKET CELLS
# The NMDA/AMPA synapses @ basket cell
nmda_eqs_mb = '''
dj_mb/dt = -j_mb / t_nmda_decay_b + alpha_nmda * x_mb * (1 - j_mb) : 1
dx_mb/dt = -x_mb / t_nmda_rise_b : 1
wNMDA_mb : 1
'''
synNMDA_mb = Synapses(mossy, basket, model = nmda_eqs_mb, pre = 'x_mb += wNMDA_mb', implicit=True, freeze=True)
basket.s_nmda_mb = synNMDA_mb.j_mb
synNMDA_mb.connect_random(mossy, basket, sparseness = 1.0)
synNMDA_mb.wNMDA_mb[:, :] = 1.0
synNMDA_mb.delay[:, :] = 3.0 * ms
ampa_eqs_mb = '''
dy_mb/dt = -y_mb / t_ampa_decay_b + h_mb*alpha_ampa*(1 - y_mb) : 1
dh_mb/dt = -h_mb / t_ampa_rise_b : 1
wAMPA_mb : 1
'''
synAMPA_mb = Synapses(mossy, basket, model = ampa_eqs_mb, pre = 'h_mb += wAMPA_mb', implicit=True, freeze=True)
basket.s_ampa_mb = synAMPA_mb.y_mb
synAMPA_mb.connect_random(mossy, basket, sparseness = 1.0)
synAMPA_mb.wAMPA_mb[:, :] = 1.0
synAMPA_mb.delay[:, :] = 3.0 * ms
# BASKET CELLS ----> GRANULE CELLS (INHIBITION @ soma)
# Synapses @ granule cell (soma)
syn_bg = {}
for btog in xrange(N_cl):
gaba_eqs_bg = '''
dz_bg/dt = -z_bg / t_gaba_decay_g + r_bg*alpha_gaba*(1 - z_bg) : 1
dr_bg/dt = -r_bg / t_gaba_rise_g : 1
w_bg : 1
'''
syn_bg[btog] = Synapses(basket_cl[btog], granule_cl[btog], model = gaba_eqs_bg, pre = 'r_bg += w_bg', implicit=True, freeze=True)
granule_cl[btog].s_gaba_bg_soma = syn_bg[btog].z_bg
syn_bg[btog].connect_random(basket_cl[btog], granule_cl[btog], sparseness = 1.0)
syn_bg[btog].w_bg[:, :] = 1.0
syn_bg[btog].delay[:, :] = 0.85 * ms
# HIPP CELLS ----> GRANULE CELLS (INHIBITION @ distal dendrite)
# Synapses at granule cell distal dendrite (0)
# Synapses @ 1st dendrite
gaba_eqs_hg1 = '''
dz_hg1/dt = -z_hg1 / t_gaba_decay_g + r_hg1*alpha_gaba*(1 - z_hg1) : 1
dr_hg1/dt = -r_hg1 / t_gaba_rise_g : 1
w_hg1 : 1
'''
syn_hg1 = Synapses(hipp, granule, model = gaba_eqs_hg1, pre = 'r_hg1 += w_hg1', implicit=True, freeze=True)
granule.s_gaba_hg_dend001 = syn_hg1.z_hg1
syn_hg1.load_connectivity('syn_hg1.txt')
syn_hg1.w_hg1[:, :] = 1.0
syn_hg1.delay[:, :] = 1.6 * ms
# Synapses @ 2nd dendrite
gaba_eqs_hg2 = '''
dz_hg2/dt = -z_hg2 / t_gaba_decay_g + r_hg2*alpha_gaba*(1 - z_hg2) : 1
dr_hg2/dt = -r_hg2 / t_gaba_rise_g : 1
w_hg2 : 1
'''
syn_hg2 = Synapses(hipp, granule, model = gaba_eqs_hg2, pre = 'r_hg2 += w_hg2', implicit=True, freeze=True)
granule.s_gaba_hg_dend002 = syn_hg2.z_hg2
syn_hg2.load_connectivity('syn_hg2.txt')
syn_hg2.w_hg2[:, :] = 1.0
syn_hg2.delay[:, :] = 1.6 * ms
# Synapses @ 3rd dendrite
gaba_eqs_hg3 = '''
dz_hg3/dt = -z_hg3 / t_gaba_decay_g + r_hg3*alpha_gaba*(1 - z_hg3) : 1
dr_hg3/dt = -r_hg3 / t_gaba_rise_g : 1
w_hg3 : 1
'''
syn_hg3 = Synapses(hipp, granule, model = gaba_eqs_hg3, pre = 'r_hg3 += w_hg3', implicit=True, freeze=True)
granule.s_gaba_hg_dend101 = syn_hg3.z_hg3
syn_hg3.load_connectivity('syn_hg3.txt')
syn_hg3.w_hg3[:, :] = 1.0
syn_hg3.delay[:, :] = 1.6 * ms
# Synapses @ 4th dendrite
gaba_eqs_hg4 = '''
dz_hg4/dt = -z_hg4 / t_gaba_decay_g + r_hg4*alpha_gaba*(1 - z_hg4) : 1
dr_hg4/dt = -r_hg4 / t_gaba_rise_g : 1
w_hg4 : 1
'''
syn_hg4 = Synapses(hipp, granule, model = gaba_eqs_hg4, pre = 'r_hg4 += w_hg4', implicit=True, freeze=True)
granule.s_gaba_hg_dend102 = syn_hg4.z_hg4
syn_hg4.load_connectivity('syn_hg4.txt')
syn_hg4.w_hg4[:, :] = 1.0
syn_hg4.delay[:, :] = 1.6 * ms
# Synapses @ 5th dendrite
gaba_eqs_hg5 = '''
dz_hg5/dt = -z_hg5 / t_gaba_decay_g + r_hg5*alpha_gaba*(1 - z_hg5) : 1
dr_hg5/dt = -r_hg5 / t_gaba_rise_g : 1
w_hg5 : 1
'''
syn_hg5 = Synapses(hipp, granule, model = gaba_eqs_hg5, pre = 'r_hg5 += w_hg5', implicit=True, freeze=True)
granule.s_gaba_hg_dend201 = syn_hg5.z_hg5
syn_hg5.load_connectivity('syn_hg5.txt')
syn_hg5.w_hg5[:, :] = 1.0
syn_hg5.delay[:, :] = 1.6 * ms
# Synapses @ 6th dendrite
gaba_eqs_hg6 = '''
dz_hg6/dt = -z_hg6 / t_gaba_decay_g + r_hg6*alpha_gaba*(1 - z_hg6) : 1
dr_hg6/dt = -r_hg6 / t_gaba_rise_g : 1
w_hg6 : 1
'''
syn_hg6 = Synapses(hipp, granule, model = gaba_eqs_hg6, pre = 'r_hg6 += w_hg6', implicit=True, freeze=True)
granule.s_gaba_hg_dend202 = syn_hg6.z_hg6
syn_hg6.load_connectivity('syn_hg6.txt')
syn_hg6.w_hg6[:, :] = 1.0
syn_hg6.delay[:, :] = 1.6 * ms
############################################# N O I S E ################################################################
# GRANULE CELLS
# NOISE
noise_g = PoissonGroup(500, 0.1*Hz)
# DISTAL
# Synapses at dend001
nmda_eqs_gn001 = '''
dj_gn001/dt = -j_gn001 / t_nmda_decay_g + alpha_nmda_g * x_gn001 * (1 - j_gn001) : 1
dx_gn001/dt = -x_gn001 / t_nmda_rise_g : 1
dy_gn001/dt = -y_gn001 / t_ampa_decay_g + alpha_ampa * h_gn001 * (1 - y_gn001) : 1
dh_gn001/dt = -h_gn001 / t_ampa_rise_g : 1
w_gn001 : 1
'''
syn_gn001 = Synapses(noise_g, granule, model = nmda_eqs_gn001,
pre = 'x_gn001 = w_gn001; h_gn001 = w_gn001', implicit=True, freeze=True)
granule.s_nmda_gn_dend001 = syn_gn001.j_gn001
granule.s_ampa_gn_dend001 = syn_gn001.y_gn001
syn_gn001.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn001.w_gn001[:, :] = 1.0
syn_gn001.delay[:, :] = '10 * rand() * ms'
# Synapses at dend002
nmda_eqs_gn002 = '''
dj_gn002/dt = -j_gn002 / t_nmda_decay_g + alpha_nmda_g * x_gn002 * (1 - j_gn002) : 1
dx_gn002/dt = -x_gn002 / t_nmda_rise_g : 1
dy_gn002/dt = -y_gn002 / t_ampa_decay_g + alpha_ampa * h_gn002 * (1 - y_gn002) : 1
dh_gn002/dt = -h_gn002 / t_ampa_rise_g : 1
w_gn002 : 1
'''
syn_gn002 = Synapses(noise_g, granule, model = nmda_eqs_gn002,
pre = 'x_gn002 = w_gn002; h_gn002 = w_gn002', implicit=True, freeze=True)
granule.s_nmda_gn_dend002 = syn_gn002.j_gn002
granule.s_ampa_gn_dend002 = syn_gn002.y_gn002
syn_gn002.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn002.w_gn002[:, :] = 1.0
syn_gn002.delay[:, :] = '10 * rand() * ms'
# Synapses at dend101
nmda_eqs_gn101 = '''
dj_gn101/dt = -j_gn101 / t_nmda_decay_g + alpha_nmda_g * x_gn101 * (1 - j_gn101) : 1
dx_gn101/dt = -x_gn101 / t_nmda_rise_g : 1
dy_gn101/dt = -y_gn101 / t_ampa_decay_g + alpha_ampa * h_gn101 * (1 - y_gn101) : 1
dh_gn101/dt = -h_gn101 / t_ampa_rise_g : 1
w_gn101 : 1
'''
syn_gn101 = Synapses(noise_g, granule, model = nmda_eqs_gn101,
pre = 'x_gn101 = w_gn101; h_gn101 = w_gn101', implicit=True, freeze=True)
granule.s_nmda_gn_dend101 = syn_gn101.j_gn101
granule.s_ampa_gn_dend101 = syn_gn101.y_gn101
syn_gn101.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn101.w_gn101[:, :] = 1.0
syn_gn101.delay[:, :] = '10 * rand() * ms'
# Synapses at dend102
nmda_eqs_gn102 = '''
dj_gn102/dt = -j_gn102 / t_nmda_decay_g + alpha_nmda_g * x_gn102 * (1 - j_gn102) : 1
dx_gn102/dt = -x_gn102 / t_nmda_rise_g : 1
dy_gn102/dt = -y_gn102 / t_ampa_decay_g + alpha_ampa * h_gn102 * (1 - y_gn102) : 1
dh_gn102/dt = -h_gn102 / t_ampa_rise_g : 1
w_gn102 : 1
'''
syn_gn102 = Synapses(noise_g, granule, model = nmda_eqs_gn102,
pre = 'x_gn102 = w_gn102; h_gn102 = w_gn102', implicit=True, freeze=True)
granule.s_nmda_gn_dend102 = syn_gn102.j_gn102
granule.s_ampa_gn_dend102 = syn_gn102.y_gn102
syn_gn102.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn102.w_gn102[:, :] = 1.0
syn_gn102.delay[:, :] = '10 * rand() * ms'
# Synapses at dend201
nmda_eqs_gn201 = '''
dj_gn201/dt = -j_gn201 / t_nmda_decay_g + alpha_nmda_g * x_gn201 * (1 - j_gn201) : 1
dx_gn201/dt = -x_gn201 / t_nmda_rise_g : 1
dy_gn201/dt = -y_gn201 / t_ampa_decay_g + alpha_ampa * h_gn201 * (1 - y_gn201) : 1
dh_gn201/dt = -h_gn201 / t_ampa_rise_g : 1
w_gn201 : 1
'''
syn_gn201 = Synapses(noise_g, granule, model = nmda_eqs_gn201,
pre = 'x_gn201 = w_gn201; h_gn201 = w_gn201', implicit=True, freeze=True)
granule.s_nmda_gn_dend201 = syn_gn201.j_gn201
granule.s_ampa_gn_dend201 = syn_gn201.y_gn201
syn_gn201.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn201.w_gn201[:, :] = 1.0
syn_gn201.delay[:, :] = '10 * rand() * ms'
# Synapses at dend202
nmda_eqs_gn202 = '''
dj_gn202/dt = -j_gn202 / t_nmda_decay_g + alpha_nmda_g * x_gn202 * (1 - j_gn202) : 1
dx_gn202/dt = -x_gn202 / t_nmda_rise_g : 1
dy_gn202/dt = -y_gn202 / t_ampa_decay_g + alpha_ampa * h_gn202 * (1 - y_gn202) : 1
dh_gn202/dt = -h_gn202 / t_ampa_rise_g : 1
w_gn202 : 1
'''
syn_gn202 = Synapses(noise_g, granule, model = nmda_eqs_gn202,
pre = 'x_gn202 = w_gn202; h_gn202 = w_gn202', implicit=True, freeze=True)
granule.s_nmda_gn_dend202 = syn_gn202.j_gn202
granule.s_ampa_gn_dend202 = syn_gn202.y_gn202
syn_gn202.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn202.w_gn202[:, :] = 1.0
syn_gn202.delay[:, :] = '10 * rand() * ms'
# MEDIAL
# Synapses at dend011
nmda_eqs_gn011 = '''
dj_gn011/dt = -j_gn011 / t_nmda_decay_g + alpha_nmda_g * x_gn011 * (1 - j_gn011) : 1
dx_gn011/dt = -x_gn011 / t_nmda_rise_g : 1
dy_gn011/dt = -y_gn011 / t_ampa_decay_g + alpha_ampa * h_gn011 * (1 - y_gn011) : 1
dh_gn011/dt = -h_gn011 / t_ampa_rise_g : 1
w_gn011 : 1
'''
syn_gn011 = Synapses(noise_g, granule, model = nmda_eqs_gn011,
pre = 'x_gn011 = w_gn011; h_gn011 = w_gn011', implicit=True, freeze=True)
granule.s_nmda_gn_dend011 = syn_gn011.j_gn011
granule.s_ampa_gn_dend011 = syn_gn011.y_gn011
syn_gn011.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn011.w_gn011[:, :] = 1.0
syn_gn011.delay[:, :] = '10 * rand() * ms'
# Synapses at dend002
nmda_eqs_gn012 = '''
dj_gn012/dt = -j_gn012 / t_nmda_decay_g + alpha_nmda_g * x_gn012 * (1 - j_gn012) : 1
dx_gn012/dt = -x_gn012 / t_nmda_rise_g : 1
dy_gn012/dt = -y_gn012 / t_ampa_decay_g + alpha_ampa * h_gn012 * (1 - y_gn012) : 1
dh_gn012/dt = -h_gn012 / t_ampa_rise_g : 1
w_gn012 : 1
'''
syn_gn012 = Synapses(noise_g, granule, model = nmda_eqs_gn012,
pre = 'x_gn012 = w_gn012; h_gn012 = w_gn012', implicit=True, freeze=True)
granule.s_nmda_gn_dend012 = syn_gn012.j_gn012
granule.s_ampa_gn_dend012 = syn_gn012.y_gn012
syn_gn012.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn012.w_gn012[:, :] = 1.0
syn_gn012.delay[:, :] = '10 * rand() * ms'
# Synapses at dend111
nmda_eqs_gn111 = '''
dj_gn111/dt = -j_gn111 / t_nmda_decay_g + alpha_nmda_g * x_gn111 * (1 - j_gn111) : 1
dx_gn111/dt = -x_gn111 / t_nmda_rise_g : 1
dy_gn111/dt = -y_gn111 / t_ampa_decay_g + alpha_ampa * h_gn111 * (1 - y_gn111) : 1
dh_gn111/dt = -h_gn111 / t_ampa_rise_g : 1
w_gn111 : 1
'''
syn_gn111 = Synapses(noise_g, granule, model = nmda_eqs_gn111,
pre = 'x_gn111 = w_gn111; h_gn111 = w_gn111', implicit=True, freeze=True)
granule.s_nmda_gn_dend111 = syn_gn111.j_gn111
granule.s_ampa_gn_dend111 = syn_gn111.y_gn111
syn_gn111.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn111.w_gn111[:, :] = 1.0
syn_gn111.delay[:, :] = '10 * rand() * ms'
# Synapses at dend112
nmda_eqs_gn112 = '''
dj_gn112/dt = -j_gn112 / t_nmda_decay_g + alpha_nmda_g * x_gn112 * (1 - j_gn112) : 1
dx_gn112/dt = -x_gn112 / t_nmda_rise_g : 1
dy_gn112/dt = -y_gn112 / t_ampa_decay_g + alpha_ampa * h_gn112 * (1 - y_gn112) : 1
dh_gn112/dt = -h_gn112 / t_ampa_rise_g : 1
w_gn112 : 1
'''
syn_gn112 = Synapses(noise_g, granule, model = nmda_eqs_gn112,
pre = 'x_gn112 = w_gn112; h_gn112 = w_gn112', implicit=True, freeze=True)
granule.s_nmda_gn_dend112 = syn_gn112.j_gn112
granule.s_ampa_gn_dend112 = syn_gn112.y_gn112
syn_gn112.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn112.w_gn112[:, :] = 1.0
syn_gn112.delay[:, :] = '10 * rand() * ms'
# Synapses at dend211
nmda_eqs_gn211 = '''
dj_gn211/dt = -j_gn211 / t_nmda_decay_g + alpha_nmda_g * x_gn211 * (1 - j_gn211) : 1
dx_gn211/dt = -x_gn211 / t_nmda_rise_g : 1
dy_gn211/dt = -y_gn211 / t_ampa_decay_g + alpha_ampa * h_gn211 * (1 - y_gn211) : 1
dh_gn211/dt = -h_gn211 / t_ampa_rise_g : 1
w_gn211 : 1
'''
syn_gn211 = Synapses(noise_g, granule, model = nmda_eqs_gn211,
pre = 'x_gn211 = w_gn211; h_gn211 = w_gn211', implicit=True, freeze=True)
granule.s_nmda_gn_dend211 = syn_gn211.j_gn211
granule.s_ampa_gn_dend211 = syn_gn211.y_gn211
syn_gn211.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn211.w_gn211[:, :] = 1.0
syn_gn211.delay[:, :] = '10 * rand() * ms'
# Synapses at dend212
nmda_eqs_gn212 = '''
dj_gn212/dt = -j_gn212 / t_nmda_decay_g + alpha_nmda_g * x_gn212 * (1 - j_gn212) : 1
dx_gn212/dt = -x_gn212 / t_nmda_rise_g : 1
dy_gn212/dt = -y_gn212 / t_ampa_decay_g + alpha_ampa * h_gn212 * (1 - y_gn212) : 1
dh_gn212/dt = -h_gn212 / t_ampa_rise_g : 1
w_gn212 : 1
'''
syn_gn212 = Synapses(noise_g, granule, model = nmda_eqs_gn212,
pre = 'x_gn212 = w_gn212; h_gn212 = w_gn212', implicit=True, freeze=True)
granule.s_nmda_gn_dend212 = syn_gn212.j_gn212
granule.s_ampa_gn_dend212 = syn_gn212.y_gn212
syn_gn212.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn212.w_gn212[:, :] = 1.0
syn_gn212.delay[:, :] = '10 * rand() * ms'
# PROXIMAL
# Synapses at dend02
nmda_eqs_gn02 = '''
dj_gn02/dt = -j_gn02 / t_nmda_decay_g + alpha_nmda_g * x_gn02 * (1 - j_gn02) : 1
dx_gn02/dt = -x_gn02 / t_nmda_rise_g : 1
dy_gn02/dt = -y_gn02 / t_ampa_decay_g + alpha_ampa * h_gn02 * (1 - y_gn02) : 1
dh_gn02/dt = -h_gn02 / t_ampa_rise_g : 1
w_gn02 : 1
'''
syn_gn02 = Synapses(noise_g, granule, model = nmda_eqs_gn02,
pre = 'x_gn02 = w_gn02; h_gn02 = w_gn02', implicit=True, freeze=True)
granule.s_nmda_gn_dend02 = syn_gn02.j_gn02
granule.s_ampa_gn_dend02 = syn_gn02.y_gn02
syn_gn02.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn02.w_gn02[:, :] = 1.0
syn_gn02.delay[:, :] = '10 * rand() * ms'
# Synapses at dend12
nmda_eqs_gn12 = '''
dj_gn12/dt = -j_gn12 / t_nmda_decay_g + alpha_nmda_g * x_gn12 * (1 - j_gn12) : 1
dx_gn12/dt = -x_gn12 / t_nmda_rise_g : 1
dy_gn12/dt = -y_gn12 / t_ampa_decay_g + alpha_ampa * h_gn12 * (1 - y_gn12) : 1
dh_gn12/dt = -h_gn12 / t_ampa_rise_g : 1
w_gn12 : 1
'''
syn_gn12 = Synapses(noise_g, granule, model = nmda_eqs_gn12,
pre = 'x_gn12 = w_gn12; h_gn12 = w_gn12', implicit=True, freeze=True)
granule.s_nmda_gn_dend12 = syn_gn12.j_gn12
granule.s_ampa_gn_dend12 = syn_gn12.y_gn12
syn_gn12.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn12.w_gn12[:, :] = 1.0
syn_gn12.delay[:, :] = '10 * rand() * ms'
# Synapses at dend22
nmda_eqs_gn22 = '''
dj_gn22/dt = -j_gn22 / t_nmda_decay_g + alpha_nmda_g * x_gn22 * (1 - j_gn22) : 1
dx_gn22/dt = -x_gn22 / t_nmda_rise_g : 1
dy_gn22/dt = -y_gn22 / t_ampa_decay_g + alpha_ampa * h_gn22 * (1 - y_gn22) : 1
dh_gn22/dt = -h_gn22 / t_ampa_rise_g : 1
w_gn22 : 1
'''
syn_gn22 = Synapses(noise_g, granule, model = nmda_eqs_gn22,
pre = 'x_gn22 = w_gn22; h_gn22 = w_gn22', implicit=True, freeze=True)
granule.s_nmda_gn_dend22 = syn_gn22.j_gn22
granule.s_ampa_gn_dend22 = syn_gn22.y_gn22
syn_gn22.connect_random(noise_g, granule, sparseness = 1.0/Nseg)
syn_gn22.w_gn22[:, :] = 1.0
syn_gn22.delay[:, :] = '10 * rand() * ms'
# BASKET CELLS
noise_b = PoissonGroup(20*N_basket, 3*Hz)
noise_b_cl = {}
for no in xrange(N_basket):
noise_b_cl[no] = noise_b.subgroup(20)
# Synapses at basket cell (noise role)
syn_bn = {}
for cell0 in xrange(N_basket):
nmda_eqs_bn = '''
dj_bn/dt = -j_bn / t_nmda_decay_bn + alpha_nmda * x_bn * (1 - j_bn) : 1
dx_bn/dt = -x_bn / t_nmda_rise_bn : 1
dy_bn/dt = -y_bn / t_ampa_decay_bn + alpha_ampa * h_bn * (1 - y_bn) : 1
dh_bn/dt = -h_bn / t_ampa_rise_bn : 1
w_bn : 1
'''
syn_bn[cell0] = Synapses(noise_b_cl[cell0], basket_cl[cell0], model = nmda_eqs_bn,
pre = 'x_bn = w_bn; h_bn = w_bn')
basket_cl[cell0].s_nmda_bn = syn_bn[cell0].j_bn
basket_cl[cell0].s_ampa_bn = syn_bn[cell0].y_bn
syn_bn[cell0].connect_random(noise_b_cl[cell0], basket_cl[cell0], sparseness = 1.0)
syn_bn[cell0].w_bn[:, :] = 1.0
syn_bn[cell0].delay[:, :] = '10 * rand() * ms'
# MOSSY CELLS
noise = PoissonGroup(30*N_mossy, 3.8*Hz)
noise_cl = {}
mossy_cl = {}
for no in xrange(N_mossy):
noise_cl[no] = noise.subgroup(20)
mossy_cl[no] = mossy[no]
# Synapses at mossy cell (noise role)
syn_mn = {}
for kk in xrange(N_mossy):
nmda_eqs_mn = '''
dj_mn/dt = -j_mn / t_nmda_decay_mn + alpha_nmda * x_mn * (1 - j_mn) : 1
dx_mn/dt = -x_mn / t_nmda_rise_mn : 1
dy_mn/dt = -y_mn / t_ampa_decay_mn + alpha_ampa * h_mn * (1 - y_mn) : 1
dh_mn/dt = -h_mn / t_ampa_rise_mn : 1
w_mn : 1
'''
syn_mn[kk] = Synapses(noise_cl[kk], mossy_cl[kk], model = nmda_eqs_mn,
pre = 'x_mn = w_mn; h_mn = w_mn')
mossy_cl[kk].s_nmda_mn = syn_mn[kk].j_mn
mossy_cl[kk].s_ampa_mn = syn_mn[kk].y_mn
syn_mn[kk].connect_random(noise_cl[kk], mossy_cl[kk], sparseness = 1.0)
syn_mn[kk].w_mn[:, :] = 1.0
syn_mn[kk].delay[:, :] = '10 * rand() * ms'
# HIPP Cells
noise_h = PoissonGroup(20*N_hipp, 3*Hz)
noise_h_cl = {}
hipp_cl = {}
for no in xrange(N_hipp):
noise_h_cl[no] = noise_h.subgroup(20)
hipp_cl[no] = hipp[no]
# Synapses at hipp cell (noise role)
syn_hn = {}
for cell2 in xrange(N_hipp):
nmda_eqs_hn = '''
dj_hn/dt = -j_hn / t_nmda_decay_hn + alpha_nmda * x_hn * (1 - j_hn) : 1
dx_hn/dt = -x_hn / t_nmda_rise_hn : 1
dy_hn/dt = -y_hn / t_ampa_decay_hn + alpha_ampa * h_hn * (1 - y_hn) : 1
dh_hn/dt = -h_hn / t_ampa_rise_hn : 1
w_hn : 1
'''
syn_hn[cell2] = Synapses(noise_h_cl[cell2], hipp_cl[cell2], model = nmda_eqs_hn,
pre = 'x_hn = w_hn; h_hn = w_hn')
hipp_cl[cell2].s_nmda_hn = syn_hn[cell2].j_hn
hipp_cl[cell2].s_ampa_hn = syn_hn[cell2].y_hn
syn_hn[cell2].connect_random(noise_h_cl[cell2], hipp_cl[cell2], sparseness = 1.0)
syn_hn[cell2].w_hn[:, :] = 1.0
syn_hn[cell2].delay[:, :] = '10 * rand() * ms'
#=======================================================================================================================
#=======================================================================================================================
# MONITORING
I_S = SpikeMonitor(Input_ec)
G_S = SpikeMonitor(granule)
#=======================================================================================================================
#=======================================================================================================================
# *************************************** S I M U L A T I O N S ********************************************
#=======================================================================================================================
#Simulation run
start_timestamp = time.time()
run(t1+simtime+t2, report='text', report_period = 1 *second)
sim_duration = time.time() - start_timestamp
print "\nDuration of simulation: " + str(sim_duration)
os.chdir('../')
output_pattern = []
for spikes in xrange(N_granule):
output_pattern.append(len(G_S[spikes]))
np.save('output_pattern6d_'+str(Trial), output_pattern)
input_pattern = []
for spikes_i in xrange(len(Input_ec)):
input_pattern.append(len(I_S[spikes_i]))
np.save('input_pattern6d_'+str(Trial), input_pattern)