TITLE SHL1
: Shal current cultured myocites
: Fawcett 2006
UNITS {
(mA) = (milliamp)
(S) = (siemens)
(mV) = (millivolt)
}
NEURON {
SUFFIX shl1
USEION k READ ek WRITE ik
RANGE gbar,g,curr
}
PARAMETER{
ek (mV)
celsius (degC)
gbar=2.9 (S/cm2)
vashal=11.2 (mV)
kashal=14.1 (mV)
kishal=8.3 (mV)
vishal=-33.1 (mV)
shalsfhit=18 (mV)
ptmshal1=13.8 (ms)
ptmshal2=-17.5165 (mV)
ptmshal3=12.9213 (mV)
ptmshal4=-3.7082 (mV)
ptmshal5=6.4876 (mV)
ptmshal6=1.8849 (ms)
pthfshal1=539.1584 (ms)
pthfshal2=-28.1990 (mV)
pthfshal3=4.9199 (mV)
pthfshal4=27.2811 (ms)
pthsshal1=8422 (ms)
pthsshal2=-37.7391 (mV)
pthsshal3=6.3785 (mV)
pthsshal4=118.8983 (ms)
cshal=0.1 (1)
c2shal=0.1 (1)
c3shal=0.1 (1)
}
ASSIGNED{
ik (mA/cm2)
curr (mA/cm2)
g (S/cm2)
v (mV)
}
STATE {
m hs hf
}
BREAKPOINT {
SOLVE states METHOD cnexp
g=gbar*m*m*m*((0.7*hf)+(0.3*hs))
curr=gbar*m*m*m*((0.7*hf)+(0.3*hs))*(v-ek)
ik = gbar*m*m*m*((0.7*hf)+(0.3*hs))*(v-ek)
}
INITIAL {
m=minf(v)
hs=hinf(v)
hf=hinf(v)
}
DERIVATIVE states {
m' = (minf(v) - m)/mtau(v)
hs'=(hinf(v)-hs)/htaus(v)
hf'=(hinf(v)-hf)/htauf(v)
}
FUNCTION minf(v (mV)) {
UNITSOFF
minf=1/(1+exp(-(v-vashal+shalsfhit)/kashal))
UNITSON
}
FUNCTION hinf(v (mV)){
UNITSOFF
hinf = 1/(1+exp((v-vishal+shalsfhit)/kishal))
UNITSON
}
FUNCTION mtau(v(mV)){
UNITSOFF
mtau=(ptmshal1/(exp(-(v-ptmshal2)/ptmshal3)+exp((v-ptmshal4)/ptmshal5))+ptmshal6)*cshal
UNITSON
}
FUNCTION htauf(v(mV)){
UNITSOFF
htauf=(pthfshal1/(1+exp((v-pthfshal2)/pthfshal3))+pthfshal4)*c3shal
UNITSON
}
FUNCTION htaus(v(mV)){
htaus=(pthsshal1/(1+exp((v-pthsshal2)/pthsshal3))+pthsshal4)*c2shal
}