function CM = simConn_L23toL23_NGtoAll(ADO_Mat, postIND, postType, AxonRatio, DendRatio)
% ADO_Mat: axon-dendritic overlap matrix
% postIND: indexing to seperate different type of post synaptic cells
% postType: numbers specify the type of post-synaptic cell
% keyboard
% connectivity matrix need to be calculated for each type of post synaptic
% cell
for i = 1:length(postIND) - 1
temp = ADO_Mat(postIND(i)+1:postIND(i+1), :);
% ADO_temp = temp;
% DM = DMs(postIND(i)+1:postIND(i+1), :);
% DR = DendRatio(postIND(i)+1:postIND(i+1));
switch postType(i)
case(1) % post-synaptic cell is pyramidal
CM(postIND(i)+1:postIND(i+1), :) = simConn_L23toL23_NGtoPyr(temp, AxonRatio, DendRatio(postIND(i)+1:postIND(i+1)));
case{2, 3} % post-synaptic cell is FsPV or chandiler
CM(postIND(i)+1:postIND(i+1), :) = simConn_L23toL23_NGtoFsPV(temp, AxonRatio, DendRatio(postIND(i)+1:postIND(i+1)));
case(4) % post-synaptic cell is RsPV
CM(postIND(i)+1:postIND(i+1), :) = simConn_L23toL23_NGtoRsPV(temp, AxonRatio, DendRatio(postIND(i)+1:postIND(i+1)));
case{5, 6} % post-synaptic cell is MarSOM
CM(postIND(i)+1:postIND(i+1), :) = simConn_L23toL23_NGtoMarSOM(temp, AxonRatio, DendRatio(postIND(i)+1:postIND(i+1)));
case{7, 8} % post-synaptic cell is BipVIP
CM(postIND(i)+1:postIND(i+1), :) = simConn_L23toL23_NGtoBipVIP(temp, AxonRatio, DendRatio(postIND(i)+1:postIND(i+1)));
case(9) % post-synaptic cell is BipCR
CM(postIND(i)+1:postIND(i+1), :) = simConn_L23toL23_NGtoBipCR(temp, AxonRatio, DendRatio(postIND(i)+1:postIND(i+1)));
case(10) % post-synaptic cell in SbcCR
CM(postIND(i)+1:postIND(i+1), :) = simConn_L23toL23_NGtoSbcCR(temp, AxonRatio, DendRatio(postIND(i)+1:postIND(i+1)));
case(11) % post-synaptic cell in NG cells
CM(postIND(i)+1:postIND(i+1), :) = simConn_L23toL23_NGtoNG(temp, AxonRatio, DendRatio(postIND(i)+1:postIND(i+1)));
end
end
%% nested function
function CMs = simConn_L23toL23_NGtoPyr(ADO_temp, AR, DR)
% map axon-dendrite overlapping index into connectivity matrix
% the value is normalized to meausre average connection probability
% from experiment; for NG-Pyr connection, within 150 micron p =
% 0.5
% also total number of connection is controlled by the axon and
% dendrite ratio in the model region
% assuming a total convengenc/divergence rate of 140 for total
% connection
pConn = ADO_temp/5.1154e-12*0.46;
% convert pConn into binary connectivity matrix
RI = rand(size(pConn));
CMs = zeros(size(pConn));
CMs(RI < pConn) = 1;
CMs = conn_reduction(CMs, 460*AR', 15*DR');
end
function CMs = simConn_L23toL23_NGtoFsPV(ADO_temp, AR, DR)
% for NG-FsPV connection, within 150 micron p =
% 0.4
% assuming a total convengenc rate of 700 and divergence rate of 90
pConn = ADO_temp/4.6071e-12*0.4;
% convert pConn into binary connectivity matrix
RI = rand(size(pConn));
CMs = zeros(size(pConn));
CMs(RI < pConn) = 1;
CMs = conn_reduction(CMs, 21*AR', 15*DR');
end
function CMs = simConn_L23toL23_NGtoRsPV(ADO_temp, AR, DR)
% for NG-RsPV connection, 0.4
% assuming a total convengenc rate of 240 and divergence rate of 40
pConn = ADO_temp/4.1930e-12*0.4;
% convert pConn into binary connectivity matrix
RI = rand(size(pConn));
CMs = zeros(size(pConn));
CMs(RI < pConn) = 1;
CMs = conn_reduction(CMs, 18*AR', 12*DR');
end
function CMs = simConn_L23toL23_NGtoMarSOM(ADO_temp, AR, DR)
% for NG-MarSOM connection, 0.4 with 150
% assuming a total convengenc rate of 700 and divergence rate of 90
pConn = ADO_temp/4.7468e-12*0.4;
% convert pConn into binary connectivity matrix
RI = rand(size(pConn));
CMs = zeros(size(pConn));
CMs(RI < pConn) = 1;
CMs = conn_reduction(CMs, 15*AR', 12*DR');
end
function CMs = simConn_L23toL23_NGtoBipVIP(ADO_temp, AR, DR)
% for NG-BipVIP connection, within 150 micron p =
% 0.4
% assuming a total convengenc rate of 700 and divergence rate of 90
pConn = ADO_temp/4.8968e-12*0.4;
% convert pConn into binary connectivity matrix
RI = rand(size(pConn));
CMs = zeros(size(pConn));
CMs(RI < pConn) = 1;
CMs = conn_reduction(CMs, 18*AR', 15*DR');
end
function CMs = simConn_L23toL23_NGtoBipCR(ADO_temp, AR, DR)
% for NG-BipCR connection, 0.4
% assuming a total convengenc rate of 700 and divergence rate of 90
pConn = ADO_temp/2.8668e-12*0.5;
% convert pConn into binary connectivity matrix
RI = rand(size(pConn));
CMs = zeros(size(pConn));
CMs(RI < pConn) = 1;
CMs = conn_reduction(CMs, 21*AR', 15*DR');
end
function CMs = simConn_L23toL23_NGtoSbcCR(ADO_temp, AR, DR)
% for NG-SbcCR connection, within 150 micron p =
% 0.4
% assuming a total convengenc rate of 700 and divergence rate of 90
pConn = ADO_temp/4.8968e-12*0.4;
% convert pConn into binary connectivity matrix
RI = rand(size(pConn));
CMs = zeros(size(pConn));
CMs(RI < pConn) = 1;
CMs = conn_reduction(CMs, 14*AR', 12*DR');
end
function CMs = simConn_L23toL23_NGtoNG(ADO_temp, AR, DR)
% for NG-NG connection, within 150 micron p =
% 0.4
% assuming a total convengenc rate of 700 and divergence rate of 90
pConn = ADO_temp/3.9968e-12*0.4;
% convert pConn into binary connectivity matrix
RI = rand(size(pConn));
CMs = zeros(size(pConn));
CMs(RI < pConn) = 1;
CMs = conn_reduction(CMs, 13*AR', 13*DR');
end
end
% %%
% %check connection probability as a function of distance
% bin = 0:25:500;
% N_all = [0, cumsum(NiN2)];
% Pconn = {};
% for post = 1:length(N_all) - 1
% Pconn{post,1} = PConn_pairs(CM_modified(N_all(post)+1:N_all(post+1),:), ...
% bin, DM(N_all(post)+1:N_all(post+1), :));
% end