TITLE peak.mod
COMMENT
pk: record peak time and peak value of membrane potential
Michael Hausser & Arnd Roth 25.9.1997
Philipp Vetter modified last 30.12.1998
vpeak/tpeak are locked to first peak
dvdt2 is for time t - 2*dt
AP measurements dvdtmax, dvdtmaxII, onset, vonset, halfwidth, vhalf, vrest, dVdr
electrotonic lengths X, Xsec
impedance mismatch Zmismatch, Rmismatch, aZmismatch, aRmismatch, f
Copyright (C) 2001 Philipp Vetter, Arnd Roth and Michael Hausser
This program is free software; you can redistribute it and/or
modify it under the terms of the GNU General Public License
as published by the Free Software Foundation; either version 2
of the License, or (at your option) any later version.
This program is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
GNU General Public License for more details.
You should have received a copy of the GNU General Public License
along with this program; if not, write to the Free Software
Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA 02111-1307, USA.
ENDCOMMENT
UNITS {
(mV) = (millivolt)
(Mohms) = (megohms)
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX pk
RANGE tpeak, vpeak, vpeakm
RANGE dvdtpeak, dvdt2peak, onset_ref, onset, vonset, halfwidth, vhalf, vrest, dvdr
RANGE Zmismatch, Rmismatch, aZmismatch, aRmismatch, f
RANGE Zback, Rback, aZback, aRback
RANGE Zfwd, Rfwd, aZfwd, aRfwd
RANGE Z, R, aZ, aR
RANGE Xsec, Xfrc, Xlen, Xo, sign
RANGE dvdt2
}
PARAMETER {
vhalf (mV)
v (mV)
dt (ms)
}
ASSIGNED {
tpeak (ms)
vpeak (mV)
vpeakm (mV)
dvdt (ms)
dvdt2 (mV/ms*ms)
dvdt2peak (mV/ms*ms)
dvdtpeak (mV/ms)
onset_ref (mV/ms)
onset (ms)
v1 (mV)
v2 (mV)
v3 (mV)
vonset (mV)
halfwidth (ms)
below
below_old
upstroke (ms)
downstroke (ms)
dvdr (mv/micron)
vrest (mV)
Rmismatch (1)
Zmismatch (1)
Rback (Mohm)
Zback (Mohm)
Rfwd (Mohm)
Zfwd (Mohm)
R (Mohm)
Z (Mohm)
aRmismatch (1)
aZmismatch (1)
aRback (Mohm)
aZback (Mohm)
aRfwd (Mohm)
aZfwd (Mohm)
aR (Mohm)
aZ (Mohm)
f (0.001/ms)
Xo (1)
Xlen (1)
Xsec (1)
Xfrc (1)
sign (1)
}
INITIAL {
tpeak = 0 (ms)
vpeak = -100 (mV)
vpeakm = -100 (mV)
onset = 0 (ms)
dvdtpeak = 0 (mV/ms)
dvdt2peak = 0 (mV/ms)
downstroke = 0 (ms)
upstroke = 0 (ms)
vrest = v
check()
}
BREAKPOINT { SOLVE check }
PROCEDURE check() {
if (v > vpeak && vpeakm==-100) { tpeak = t
vpeak = v }
if (v+4 < vpeak) { vpeakm = 1 }
v1 = v2
v2 = v3
v3 = v
dvdt = (v3 - v2)/(dt)
dvdt2 = (v3 - 2*v2 +v1)/(dt*dt)
if (dvdt > dvdtpeak) { dvdtpeak = dvdt }
if (dvdt2 > dvdt2peak) { dvdt2peak = dvdt2 }
if (dvdt > onset_ref && onset == 0 && t > 1) { onset = t-dt
vonset = v2 }
below = 0
if (vhalf > v) {below = 1}
if (below == 0 && below_old == 1 && upstroke == 0) {upstroke = t}
if (below == 1 && below_old == 0 && downstroke == 0) {downstroke = t}
halfwidth = downstroke - upstroke
below_old = below
}