// genesis // Setting the axonal propagation velocity float CABLE_VEL = 1 // scale factor = 1/(cable velocity) sec/meter //float destlim = {P5RSa_P6RSc_destlim} float destlim = 1.0 // being lazy; should calculate based on model size instead /* * Usage : * volumeconnect source-path destination-path * [-relative] * [-sourcemask {box,ellipse} x1 y1 x2 y2] * [-sourcehole {box,ellipse} x1 y1 x2 y2] * [-destmask {box,ellipse} x1 y1 x2 y2] * [-desthole {box,ellipse} x1 y1 x2 y2] * [-probability p] */ //P5RSa - P6RSc AMPA str s //Load synapse location array str locations = "apdend1 apdend2 apdend3 apdend4 apdend5 apdend6 apdend7 apdend8 apdend9 apdend10 apobdistLa apobdistLb apobdistLc apobmidLa apobmidLb apobmidLc apobproxLa apobproxLb apobproxLc apobdistRa apobdistRb apobdistRc apobmidRa apobmidRb apobmidRc apobproxRa apobproxRb apobproxRc basalLsupera basalLsuperb basalLsuperc basalLmida basalLmidb basalLmidc basalRsupera basalRsuperb basalRsuperc basalRmida basalRmidb basalRmidc basaldeepa basaldeepb basaldeepc" foreach s ({arglist {locations}}) barrierall //ayu rvolumeconnect /P5RSanet/P5RSa[]/soma/spk23longrange \ /P6RScnet/P6RSc[]/{s}/Ex_ch13P5RSAMPA@{distantnodes} \ -relative \ -sourcemask box -1 -1 -1 1 1 1 \ -destmask box -{destlim} -{destlim} -1 {destlim} {destlim} 1 \ -desthole box -0.000001 -0.000001 -0.000001 0.000001 0.000001 0.000001 \ -probability {{longrangeprobscale}*{P5RSa_P6RSc_prob}} //-probability 0.5 end //P5RSa - P6RSc NMDA str s //Load synapse location array str locations = "apdend1 apdend2 apdend3 apdend4 apdend5 apdend6 apdend7 apdend8 apdend9 apdend10 apobdistLa apobdistLb apobdistLc apobmidLa apobmidLb apobmidLc apobproxLa apobproxLb apobproxLc apobdistRa apobdistRb apobdistRc apobmidRa apobmidRb apobmidRc apobproxRa apobproxRb apobproxRc basalLsupera basalLsuperb basalLsuperc basalLmida basalLmidb basalLmidc basalRsupera basalRsuperb basalRsuperc basalRmida basalRmidb basalRmidc basaldeepa basaldeepb basaldeepc" foreach s ({arglist {locations}}) barrierall //ayu rvolumeconnect /P5RSanet/P5RSa[]/soma/spk23longrange \ /P6RScnet/P6RSc[]/{s}/Ex_ch13P5RSNMDA@{distantnodes} \ -relative \ -sourcemask box -1 -1 -1 1 1 1 \ -destmask box -{destlim} -{destlim} -1 {destlim} {destlim} 1 \ -desthole box -0.000001 -0.000001 -0.000001 0.000001 0.000001 0.000001 \ -probability {{longrangeprobscale}*{P5RSa_P6RSc_prob}} end // For inhibitory long range connections ////P5RSa - P6RSc GABAa //str s ////Load synapse location array //str locations = "apdend1 apdend2 apdend3 apdend4 apdend5 apdend6 apdend7 apdend8 apdend9 apdend10 apobdistLa apobdistLb apobdistLc apobmidLa apobmidLb apobmidLc apobproxLa apobproxLb apobproxLc apobdistRa apobdistRb apobdistRc apobmidRa apobmidRb apobmidRc apobproxRa apobproxRb apobproxRc basalLsupera basalLsuperb basalLsuperc basalLmida basalLmidb basalLmidc basalRsupera basalRsuperb basalRsuperc basalRmida basalRmidb basalRmidc basaldeepa basaldeepb basaldeepc" // //foreach s ({arglist {locations}}) // // barrierall //ayu // rvolumeconnect /P5RSanet/P5RSa[]/soma/spk23longrange \ // /P6RScnet/P6RSc[]/{s}/Inh_ch13P5RSGABAa@{distantnodes} \ // -relative \ // -sourcemask box -1 -1 -1 1 1 1 \ // -destmask box -{destlim} -{destlim} -1 {destlim} {destlim} 1 \ // -desthole box -0.000001 -0.000001 -0.000001 0.000001 0.000001 0.000001 \ // -probability {{longrangeprobscale}*{P5RSa_P6RSc_prob}} // //end // assigning delays barrierall //ayu rvolumedelay /P5RSanet/P5RSa[]/soma/spk23longrange -radial {{P5RSa_P6RSc_axdelayCV}*{longrangeCVscale}} -add // assigning weights float P5RSamaxweight = 1.0 float P5RSaminweight = 0.0 float P5RSadecayrate = 0.1 float longrangeweight = {longrangeweightscale}*{{{P5RSamaxweight}-{P5RSaminweight}} * {exp {-1*{sqrt {{NX}^2*{SEPX}^2*{sqrtNnodesperregion}+{NY}^2*{SEPY}^2*{sqrtNnodesperregion}} }*P5RSadecayrate} } + {P5RSaminweight}} barrierall //ayu rvolumeweight /P5RSanet/P5RSa[]/soma/spk23longrange -fixed {longrangeweight}