TITLE Fast Na channel for LGMD
: Altered by RBD 7/2016
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
(S) = (siemens)
}
NEURON {
THREADSAFE
SUFFIX Na
USEION na READ ena WRITE ina
GLOBAL dam, dbm
RANGE gmax, g
}
PARAMETER {
: all values can be adjusted in hoc files
gmax= 0.045 (S/cm2)
kam=0.07 (/mV)
Aam=18.7 (/ms)
dam=-4 (mV)
kbm=0.065 (/mV)
Abm=5 (/ms)
dbm=-31.5 (mV)
kah=0.15 (/mV)
Aah=1 (/ms)
dah=-53 (mV)
kbh=0.14 (/mV)
Abh=6 (/ms)
dbh=-25 (mV)
}
ASSIGNED {
v (mV)
ena (mV)
ina (mA/cm2)
am (/ms)
bm (/ms)
ah (/ms)
bh (/ms)
g (S/cm2)
}
STATE {
m h
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gmax*m^3*h
ina = g*(v-ena)
}
INITIAL {
settables(v)
m = am/(am+bm)
h = ah/(ah+bh)
}
DERIVATIVE states {
settables(v)
m' = ((am*(1-m)) - (bm*m))
h' = ((ah*(1-h)) - (bh*h))
}
UNITSOFF
PROCEDURE settables(v (mV)) {
TABLE am, bm, ah, bh DEPEND dam, dbm, dah, dbh
FROM -100 TO 50 WITH 750
if (v > (dam-0.01) && v < (dam+0.01)) {
am = Aam
} else {
am = kam*-Aam*(dam-v) / (1 - exp((dam-v)*kam))
}
bm = Abm*exp( (dbm-v)*kbm)
ah = Aah*exp( (dah-v)*kah)
bh = Abh/(exp( (dbh-v)* kbh) + 1)
}
UNITSON