/*//////////////////// Biophysics ////////////////////
Channel mechanisms:
pas = passive leak conductance
KM = M conductance (DGC_M.mod)
KA = A-type conductance (Aradi_KA.mod)
fKDR = fast delayed rectifier (Aradi_KDRf.mod)
sKDR = fast delayed rectifier (Aradi_KDRs.mod)
CaDep = SK and BK channels (Aradi_CadepK.mod)
sAHP = slow AHP conductance (DGC_sAHP.mod)
Na = transient Na conductance (Aradi_Na.mod)
Ca = T, N and L -type Ca channels (Aradi_Ca.mod)
UK = ad-hoc unknown conductance (DGC_UK.mod)
"g...bar" indicates a specific conductance while
"mult" and "div" indicate multipliers and divisors. See
the .mod files and the panel in "SetUp.hoc" for units.
/*////////////////////////////////////////////////////
proc InsertChannels() {
forsec all {
insert pas
g_pas = gpas
e_pas = Epas
}
forsec dendrites {
cm = 1.6*cm0
insert pas
g_pas = 4e-05
e_pas = Epas
}
forsec GCLs {
insert Ca
gtcabar_Ca = CaTmult*0.0003
gncabar_Ca = CaNmult*0.003
glcabar_Ca = CaLmult*0.015
insert CadepK
gbkbar_CadepK = BKmult*0.0003
gskbar_CadepK = gskGCLs
insert Na
gbar_Na = gNaT_mult*0.018
insert fKDR
gbar_fKDR = 0.004
insert sKDR
gbar_sKDR = 0.003
}
forsec proxs {
insert Ca
gtcabar_Ca = CaTmult*0.001
gncabar_Ca = CaNmult*0.001
glcabar_Ca = CaLmult*0.015
insert CadepK
gbkbar_CadepK = BKmult*0.0005
gskbar_CadepK = gskprox
insert Na
gbar_Na = gNaT_mult*0.013
insert fKDR
gbar_fKDR = 0.004
insert sKDR
gbar_sKDR = 0.003
}
forsec middles {
insert Ca
gtcabar_Ca = CaTmult*0.002
gncabar_Ca = CaNmult*0.001
glcabar_Ca = CaLmult*0.001
insert CadepK
gbkbar_CadepK = BKmult*0.0012
gskbar_CadepK = 0.0
insert Na
gbar_Na = gNaT_mult*0.008
insert fKDR
gbar_fKDR = 0.001
insert sKDR
gbar_sKDR = 0.003
}
forsec distals {
insert Ca
gtcabar_Ca = CaTmult*0.002
gncabar_Ca = CaNmult*0.001
glcabar_Ca = 0.0
insert CadepK
gbkbar_CadepK = BKmult*0.0012
gskbar_CadepK = 0.0
insert fKDR
gbar_fKDR = 0.001
insert sKDR
gbar_sKDR = 0.004
}
forsec allaxon {
insert Na
gbar_Na = gNaT_mult*0.21 //0.04 (S-H)
insert fKDR
gbar_fKDR = 0.028
insert KA
gbar_KA = gKAa //0.004
insert KM
k_KM = kKM
v0erev_KM = v0erevKM
kV_KM = kVM
gamma_KM = gammaKM
taudiv_KM = taudivKM
Dtaumult1_KM = Dtaumult1
Dtaumult2_KM = Dtaumult2
Vshift_KM = VshiftKM
tau0mult_KM = tau0mult
gbar_KM = gMaxon
}
soma {
insert Ca
gtcabar_Ca = CaTmult*0.00015
gncabar_Ca = CaNmult*0.002
glcabar_Ca = CaLmult*0.01
insert CadepK
gbkbar_CadepK = BKmult*0.0003
gskbar_CadepK = gsksoma
insert Na
gbar_Na = gNaT_mult*0.12
insert fKDR
gbar_fKDR = 0.016
insert sKDR
gbar_sKDR = 0.003
insert KA
gbar_KA = gKAs
insert UK
gbar_UK = gbarUK
insert sAHP
gbar_sAHP = gbarsAHP
}
forsec all {
if (ismembrane("Na")) {
ena = ENa
taumult_Na = taumultNa
}
if (ismembrane("UK")) {
erev_UK = erevUK
p_UK = pUK
tau_UK = tauUK
Vhalf_UK = VhalfUK
k_UK = kUK
taucadiv_UK = taucadiv
kca_UK = kcaUK
ca0_UK = ca0
}
if (ismembrane("Ca")) {
taucadiv_Ca = taucadiv
tauctdiv_Ca = tauctdiv
Vshift_Ca = Vshift
ca0_Ca = ca0
}
if (ismembrane("CadepK")) { ek = EK
erevSK_CadepK = erevSK
tauskdiv_CadepK = tauskdiv
taucadiv_CadepK = taucadiv
erevBK_CadepK = erevBK
ca0_CadepK = ca0
}
if (ismembrane("KM")) {erev_KM = EK}
if (ismembrane("KA")) {erev_KA = EK}
if (ismembrane("fKDR")) {
erev_fKDR = EK
gbar_fKDR = KDRmult*gbar_fKDR
v0_fKDR = V0KDR
taumult_fKDR = taumultKDR
}
if (ismembrane("sKDR")) {
erev_sKDR = EK
gbar_sKDR = KDRmult*gbar_sKDR
}
if (ismembrane("sAHP")) {
ek = EK
tau1Ref_sAHP = tau1RefsAHP
tau2_sAHP = tau2sAHP
c1inf_sAHP = c1infsAHP
oinf_sAHP = oinfsAHP
CaRef_sAHP = CaRefsAHP
kca_sAHP = kcasAHP
cah_sAHP = cahsAHP
n_sAHP = nsAHP
}
}
}